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Checkpoint Signaling and DNA Repair: ATR
 | | |  ATR Antibodies
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| Anti-ATR (Ab-2) (2122-2644) Rabbit pAb |
IB |
hamster, human, mouse |
PC538 |
| Anti-ATR (Ab-2) Rabbit pAb |
IB |
hamster, human, mouse |
PC538T |
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| | | ATR Inhibitor
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| ATM/ATR Kinase Inhibitor |
118501 |
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| | | | Additional Information | | | | | | | | |
| Protein : ATR
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| Connectivity | 212 |
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| Notes | The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. |
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| Hugo ID | 882 |
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| Name | ATR |
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| Description | ataxia telangiectasia and Rad3 related |
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| URN | urn:agi-llid:545 |
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| Cell Localization | Cytoplasm |
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| GO Biological Process | DNA damage checkpoint |
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| | DNA repair |
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| | cell cycle |
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| | cell cycle checkpoint |
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| | development |
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| Alias | Atr |
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| | ataxia telangiectasia and rad3 related |
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| | FRP1 |
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| | SCKL |
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| | SCKL1 |
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| | Seckel syndrome |
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| | protein kinase ATR |
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| | ataxia telangiectasia and Rad3 related protein |
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| | FRAP-related protein-1 |
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| | FRAP-related protein |
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| | FRAP-related protein I |
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| | FRP I |
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| | Rad3 related protein |
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| | SCKL I |
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| | similar to FRAP-related protein |
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| Organism | Mus musculus |
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| | Human |
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| Pathway | ATM signaling |
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| | DNA Repair |
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