 |
|
|
|
|
Checkpoint Signaling and DNA Repair: ATRIP
 | | | Currently we do not offer any products for ATRIP. Please check back soon.
For additional information on this protein, please refer to the general information provided below. | | | | | | |
| Protein : ATRIP
| | |
|---|
| Connectivity | 9 |
|---|
| Notes | This gene uses two different open reading frames. The upstream ORF encodes proteins which interact with the ataxia telangiectasia and Rad3 related protein, a checkpoint kinase. The proteins encoded by this upstream ORF localize to intranuclear foci following DNA damage and are essential components of the DNA damage checkpoint. The downstream ORF encodes proteins with 3' exonuclease activity. Other enzymes with this activity are involved in DNA replication, repair, and recombination. Similarity to an E. coli protein suggests that the enzymes encoded by this ORF may be a subunit of DNA polymerase III, which does not have intrinsic exonuclease activity. Both ORFs are subject to alternative splicing, resulting in six transcript variants. |
|---|
| Hugo ID | 12269 |
|---|
| Name | ATRIP |
|---|
| Description | three prime repair exonuclease 1 |
|---|
| URN | urn:agi-llid:11277 |
|---|
| | |
|---|
| GO Cellular Component | integral to membrane |
|---|
| | intracellular |
|---|
| | nucleus |
|---|
| | nuclear membrane |
|---|
| | |
|---|
| Cell Localization | Plasma membrane |
|---|
| | |
|---|
| GO Biological Process | DNA repair |
|---|
| | DNA recombination |
|---|
| | DNA replication |
|---|
| | mismatch repair |
|---|
| | |
|---|
| State | isoform A |
|---|
| | isoform c |
|---|
| | isoform B |
|---|
| | isoform d |
|---|
| | |
|---|
| State Description | Transcript Variant: Variants 1, 2, 3, and 4 use the downstream open reading frame to encode isoforms a and b. This variant (1) includes a 320 nt fragment unique to this transcript, resulting in use of a unique start codon. Its encoded isoform a has 55 ... |
|---|
| | Transcript Variant: Variants 5 and 6 use the upstream open reading frame to encode isoforms c and d. This variant (5) lacks an 81 nt internal exon as compared to variant 6. As a result its encoded isoform (c) lacks 27 internal amino acids, as compared... |
|---|
| | Transcript Variant: Variants 1, 2, 3, and 4 use the downstream open reading frame to encode isoforms a and b. This variant (2) includes four unique exons in its 5' UTR. It also lacks a 320 nt fragment compared to variant 1, resulting in the use of a do... |
|---|
| | Transcript Variant: Variants 1, 2, 3, and 4 use the downstream open reading frame to encode isoforms a and b. This variant (3) includes a 289 nt fragment, unique to variants 3 and 5, within its 5' UTR. It also lacks a 320 nt fragment compared to varian... |
|---|
| | Transcript Variant: Variants 1, 2, 3, and 4 use the downstream open reading frame to encode isoforms a and b. This variant (4) lacks a 320 nt fragment compared to variant 1, resulting in the use of a downstream start codon. It encodes isoform b, which ... |
|---|
| | Transcript Variant: Variants 5 and 6 use the upstream open reading frame to encode isoforms c and d. This variant (6) includes an 81 nt internal exon not found in variant 6. As a result its encoded isoform (d) has 27 additional internal amino acids, as... |
|---|
| | |
|---|
| Alias | Trex1 |
|---|
| | 1661 |
|---|
| | three prime repair exonuclease 1 |
|---|
| | trophoblast expressed 1 |
|---|
| | three prime exonuclease 1 |
|---|
| | 6620401K05Rik |
|---|
| | RIKEN cDNA 6620401K05 gene |
|---|
| | 5930438A12 |
|---|
| | DRN3 |
|---|
| | ATRIP |
|---|
| | 3' repair exonuclease 1 |
|---|
| | ATR interacting protein |
|---|
| | deoxyribonuclease III, dnaQ/mutD (E. coli)-like |
|---|
| | FLJ12343 |
|---|
| | DKFZp434J0310 |
|---|
| | 3' repair exonuclease I |
|---|
| | ATR interactive protein |
|---|
| | deoxyribonuclease III, dnaQ/mutD-like |
|---|
| | DNase III |
|---|
| | three prime exonuclease I |
|---|
| | three prime repair exonuclease I |
|---|
| | Trex I |
|---|
| | trophoblast expressed I |
|---|
| | |
|---|
| Organism | Mus musculus |
|---|
| | Human |
|---|
| | |
|---|
| Group | nucleic acid binding |
|---|
| | metal ion binding |
|---|
|
|
 |
|
|
