Checkpoint Signaling and DNA Repair: CDC2

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		Technical Information

		Calbiochem Information

		Interactive Pathways

		Checkpoint Signaling & DNA Repair

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CDC2 Antibodies

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Connectivity	852
Notes	The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control.
Hugo ID	1722
Name	CDC2
Description	cell division cycle 2 homolog A (S. pombe)
URN	urn:agi-llid:983


GO Cellular Component	nucleus


Cell Localization	Cytoplasm
	Nucleus


GO Biological Process	cell cycle
	mitosis
	mitotic G2 checkpoint
	protein amino acid phosphorylation
	traversing start control point of mitotic cell cycle


EC Number	2.7.1.37


State	cell division cycle 2 protein isoform 1
	cell division cycle 2 protein isoform 2


State Description	Transcript Variant: This variant (1) encodes the full length isoform.
	Transcript Variant: This variant (2), also known as CDC2 delta T, lacks an internal coding region, as compared to variant 1. The resulting protein lacks the T loop of the kinase domain and, thereby, lacks the kinase activity.


MGI ID	88351


Swiss-Prot Accession�	P06493


OMIM ID	OMIM:116940


Alias	Cdc2a
	cell division cycle 2 homolog A (S. pombe)
	Cell division cycle control protein 2
	Cdc2
	cell division cycle control protein 2a
	p34
	CDK1
	cell division cycle 2, G1 to S and G2 to M
	p34 protein kinase
	cyclin-dependent kinase 1
	cell cycle controller CDC2
	cell division control protein 2 homolog
	CDC2_HUMAN
	protein kinase cdc2
	CDK I
	cell division cycle 2
	cell division cycle 2 homolog A
	cell division cycle 2 protein isoform 1
	cell division cycle 2 protein isoform 2
	cell division cycle 2 protein isoform I
	cell division cycle II
	cyclin-dependent kinase I
	M phase-specific cdc2 kinase
	p34-CDC2


RGD ID	2319


Pathway	RB Tumor Suppressor
	DNA Repair


Group	Kinases
	nucleotide binding