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Checkpoint Signaling and DNA Repair: CDC25A
 | | |  CDC25A Antibodies
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| Anti-Cdc25A Rabbit pAb |
IB, IP |
human |
PC733 |
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| | | | Additional Information | | | | | | | | |
| Protein : CDC25A
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| Connectivity | 203 |
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| Notes | CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. |
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| Hugo ID | 1725 |
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| Name | CDC25A |
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| Description | cell division cycle 25A |
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| URN | urn:agi-llid:993 |
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| GO Cellular Component | intracellular |
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| Cell Localization | Cytoplasm |
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| GO Biological Process | G1/S transition of mitotic cell cycle |
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| | M phase of mitotic cell cycle |
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| | cytokinesis |
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| | mitosis |
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| | protein amino acid dephosphorylation |
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| | cell proliferation |
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| | regulation of cyclin dependent protein kinase activity |
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| State | isoform A |
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| | isoform B |
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| State Description | Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). |
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| | Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. |
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| Alias | Cdc25a |
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| | cell division cycle 25A |
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| | cell division cycle 25 homolog A (S. cerevisiae) |
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| | MPI1 |
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| | M-phase inducer phosphatase 1 |
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| | dual specificity phosphatase CDC25A |
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| | MPI1_HUMAN |
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| | protein-tyrosine-phosphatase cdc25A |
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| | cell division cycle 25 homolog A |
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| | Dual specificity phosphatase Cdc25A |
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| | M-phase inducer phosphatase I |
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| | MPI I |
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| Organism | Rattus norvegicus |
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| | Mus musculus |
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| | Human |
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