Checkpoint Signaling and DNA Repair: CDC25B

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Checkpoint Signaling and DNA Repair: CDC25B

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CDC25B Antibodies

Product

Application

Species Reactivity

Cat. No.

Anti-Cdc25B (Ab-1) Mouse mAb (DCS.162.2) IB, NOT FS, NOT PS human, mouse (weakly) CC25

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Additional Information

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Protein : CDC25B

SwissProt Accessions | Entrez Gene links


Connectivity	98
Notes	CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist.
Hugo ID	1726
Name	CDC25B
Description	cell division cycle 25B
URN	urn:agi-llid:994


GO Cellular Component	intracellular


Cell Localization	Cytoplasm


GO Biological Process	M phase of mitotic cell cycle
	cytokinesis
	mitosis
	protein amino acid dephosphorylation
	positive regulation of cell proliferation
	regulation of cell cycle


EC Number	3.1.3.48


State	isoform 1
	isoform 2
	isoform 3
	isoform 4
	isoform 5


State Description	Transcript Variant: This variant (1) lacks exons 2a and 4b, compared to transcript variant 4.
	Transcript Variant: This variant (2) lacks exons 4a and 4b, compared to transcript variant 4.
	Transcript Variant: This variant (3) lacks exon 4b, compared to transcript variant 4.
	Transcript Variant: This variant (4) represents the longest transcript variant and lacks exon 2a.
	Transcript Variant: This variant (5) lacks exon 1b and 4b, compared to transcript variant 4.


MGI ID	99701


Swiss-Prot Accession�	P30305


OMIM ID	OMIM:116949


Alias	Cdc25b
	cell division cycle 25B
	cell division cycle 25 homolog B (S. cerevisiae)
	MPI2
	MPI2_HUMAN
	protein-tyrosine-phosphatase cdc25B
	CDC25HU2
	cell division cycle 25 homolog B
	Dual specificity phosphatase Cdc25B
	M-phase inducer phosphatase 2
	M-phase inducer phosphatase II


Organism	Rattus norvegicus
	Mus musculus
	Human


Entrez ID�	171103
	12531
	99033
	994


RGD ID	621500


Pathway	DNA Repair


Unigene ID	Rn.11312
	Mm.38444
	Hs.153752


Group	Phosphatases