This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.
regulation of cyclin dependent protein kinase activity
regulation of mitosis
traversing start control point of mitotic cell cycle
EC Number
3.1.3.48
State
protein isoform a
protein isoform b
State Description
Transcript Variant: This variant (1) encodes the full-length protein (isoform a).
Transcript Variant: This variant (2) lacks two regions in the coding region as compared to variant 1, and encodes an isoform (b) which is 73 aa shorter than isoform a.
