Checkpoint Signaling and DNA Repair: CDK2

		Technical Resources

		Technical Information

		Calbiochem Information

		Interactive Pathways

		Checkpoint Signaling & DNA Repair

Checkpoint Signaling and DNA Repair: CDK2

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CDK2 Antibodies

Product

Application

Species Reactivity

Cat. No.

Anti-Cdk2, C-Terminal (283-298) Rabbit pAb IB, IP human, mouse, rat 219443

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CDK2 Enzyme

Product

Cat. No.

Cdk2/CycA, GST-Fusion, Human, Recombinant, S. frugiperda 325898

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CDK2 Inhibitors

Product

Cat. No.

Aloisine A 128125

Aminopurvalanol A 164640

Cdk Inhibitor, p35 219457

Cdk1/2 Inhibitor II, NU6102 217713

Cdk1/2 Inhibitor III 217714

Cdk2 Inhibitor I 219442

Cdk2 Inhibitor II 219445

Cdk2 Inhibitor III 238803

Cdk2/5 Inhibitor 219448

Cdk2/9 Inhibitor 238806

Cdk2/Cyclin Inhibitory Peptide I 238801

Cdk2/Cyclin Inhibitory Peptide II 238802

Kenpaullone 422000

Purvalanol A 540500

SU9516 572650

WHI-P180, Hydrochloride 681500

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Additional Information

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Protein : CDK2

SwissProt Accessions | Entrez Gene links


Connectivity	897
Notes	The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported.
Hugo ID	1771
Name	CDK2
Description	cyclin-dependent kinase 2
URN	urn:agi-llid:1017


GO Cellular Component	nucleus
	transcription factor complex
	cyclin-dependent protein kinase holoenzyme complex
	cytoplasm


Cell Localization	Cytoplasm
	Nucleus


GO Biological Process	cell cycle
	cytokinesis
	mitosis
	protein amino acid phosphorylation
	G2/M transition of mitotic cell cycle
	positive regulation of cell proliferation
	regulation of DNA replication
	traversing start control point of mitotic cell cycle


EC Number	2.7.1.37


State	isoform 2
	isoform 1


State Description	Transcript Variant: This variant (1) contains an extra fragment within the coding region, as compared to variant 2. It thereby encodes a protein that has an additional 34 aa internal fragment, as compared to isoform 2.
	Transcript Variant: This variant (2) lacks a fragment within the coding region, as compared to variant 1. The translation remains in-frame, and the encoded protein lacks a 34 aa fragment, as compared to isoform 1.


MGI ID	104772


Swiss-Prot Accession�	P24941


OMIM ID	OMIM:116953


Alias	Cdk2
	cyclin-dependent kinase 2
	CDK2_MOUSE
	A630093N05Rik
	p33 protein kinase
	cell devision kinase 2
	cdc2-related protein kinase
	CDK2_HUMAN
	protein kinase cdk2
	p33(CDK2)
	cell devision kinase II
	Cell division protein kinase 2
	Cell division protein kinase II
	cyclin-dependent kinase II
	RIKEN cDNA A630093N05 gene
	similar to CELL DIVISION PROTEIN KINASE 2
	similar to CELL DIVISION PROTEIN KINASE II


Organism	Rattus norvegicus
	Mus musculus
	Human


Entrez ID�	246381
	362817
	12566
	353061
	1017


RGD ID	70486


Pathway	RB Tumor Suppressor
	p53 Signaling
	DNA Repair


Unigene ID	Rn.104460
	Mm.111326
	Hs.19192


Group	Kinases
	nucleotide binding