Checkpoint Signaling and DNA Repair: GADD45A

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Checkpoint Signaling and DNA Repair: GADD45A

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Protein : GADD45A

SwissProt Accessions | Entrez Gene links


Connectivity	212
Notes	This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms.
Hugo ID	4095
Name	GADD45A
Description	growth arrest and DNA-damage-inducible 45 alpha
URN	urn:agi-llid:1647


GO Cellular Component	ribosome
	nucleus


Cell Localization	Nucleus


GO Biological Process	G2/M transition of mitotic cell cycle
	cell cycle arrest
	protein biosynthesis
	response to DNA damage stimulus
	negative regulation of protein kinase activity
	regulation of cell cycle
	DNA repair
	apoptosis
	regulation of cyclin dependent protein kinase activity


MGI ID	107799


Swiss-Prot Accession�	P24522


OMIM ID	OMIM:126335


Alias	Gadd45a
	Ddit1
	Gadd45
	growth arrest and DNA-damage-inducible 45 alpha
	DNA-damage-inducible transcript 1
	Growth arrest and DNA-damage-inducible protein
	Gadd45alpha
	DNA-damage inducible transcript 1
	growth arrest and DNA-damage-inducible, alpha
	GA45
	DNA damage-inducible transcript 1
	GA45_HUMAN
	DNA-damage-inducible protein gadd45
	AA545191
	DDIT I
	DNA- damage inducible transcript 1
	DNA- damage inducible transcript I
	expressed sequence AA545191
	GADD45 alpha
	Growth arrest and DNA-damage-inducible protein GADD45 alpha


Organism	Rattus norvegicus
	Mus musculus
	Human


Entrez ID�	25112
	13197
	101050
	1647


RGD ID	2654


Pathway	p53 Signaling
	ATM signaling
	DNA Repair


Unigene ID	Rn.10250
	Mm.1236
	Hs.80409


Group	structural constituent of ribosome