This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene.
Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
Transcript Variant: This variant (2) lacks an alternate internal segment compared to variant 1, which causes a frameshift. The resulting isoform (2) is longer and has a distinct C-terminus compared to isoform 1.
