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Checkpoint Signaling and DNA Repair: MLH1
 | | |  MLH1 Antibodies
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| Anti-MLH1 (Ab-1) Mouse mAb (14) |
IB, PS |
human |
NA28 |
| Anti-MLH1 (Ab-2) Rabbit pAb |
IB |
human, mouse |
PC56 |
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| | | | Additional Information | | | | | | | | |
| Protein : MLH1
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| Connectivity | 71 |
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| Notes | This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Alternatively spliced transcript variants encoding different isoforms have been described, but their full-length natures have not been determined. |
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| Hugo ID | 7127 |
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| Name | MLH1 |
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| Description | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) |
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| URN | urn:agi-llid:4292 |
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| GO Cellular Component | chromosome |
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| | condensed chromosome |
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| | nucleus |
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| Cell Localization | Cytoplasm |
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| | Nucleus |
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| GO Biological Process | DNA repair |
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| | mismatch repair |
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| | DNA damage response, signal transduction resulting in induction of apoptosis |
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| | male meiosis chromosome segregation |
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| | meiosis |
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| | meiotic recombination |
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| | response to DNA damage stimulus |
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| | negative regulation of cell cycle |
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| Alias | Mlh1 |
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| | mismatch repair protein 1 |
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| | mutL homolog 1 (E. coli) |
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| | DNA mismatch repair protein MLH1 |
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| | colon cancer, nonpolyposis type 2 |
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| | MutL protein homolog 1 |
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| | 1110035C23Rik |
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| | AI317206 |
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| | expressed sequence AI317206 |
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| | FCC2 |
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| | COCA2 |
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| | hMLH1 |
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| | HNPCC2 |
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| | MGC5172 |
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| | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) |
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| | mutL (E. coli) homolog 1 (colon cancer, nonpolyposis type 2) |
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| | colon cancer, nonpolyposis type II |
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| | DNA mismatch repair protein Mlh I |
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| | hMLH I |
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| | mutL homolog 1 |
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| | mutL homolog I |
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| | colon cancer, nonpolyposis type |
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| | mutL (E. coli) homolog 1 |
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| Organism | Rattus norvegicus |
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| | Mus musculus |
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| | Human |
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