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Checkpoint Signaling and DNA Repair: NBS1
 | | |  NBS1 Antibodies
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| Anti-NBS1 Rabbit pAb |
IB, IP, NT |
human |
DR1033 |
| Anti-Nibrin Rabbit pAb |
ELISA, IB, IP |
human |
PC634 |
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| | | | Additional Information | | | | | | | | |
| Protein : NBS1
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| Connectivity | 91 |
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| Notes | Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. |
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| Hugo ID | 7652 |
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| Name | NBS1 |
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| Description | nibrin |
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| URN | urn:agi-llid:4683 |
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| GO Cellular Component | nucleus |
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| | replication fork |
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| Cell Localization | Nucleus |
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| GO Biological Process | cell cycle checkpoint |
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| | regulation of cell proliferation |
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| | DNA damage checkpoint |
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| | double-strand break repair |
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| Alias | Nbn |
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| | Nbs1 |
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| | nibrin |
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| | ATV |
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| | NBS |
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| | AT-V1 |
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| | AT-V2 |
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| | p95 |
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| | Nijmegen breakage syndrome 1 (nibrin) |
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| | p95 protein of the MRE11/RAD50 complex |
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| | AT-V I |
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| | Cell cycle regulatoryprotein P95 |
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| | Nbs I |
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| | NIJMEGEN BREAKAGE syndrome protein 1 |
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| | NIJMEGEN BREAKAGE syndrome protein I |
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| Organism | Rattus norvegicus |
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| | Mus musculus |
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| | Human |
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| Pathway | ATM signaling |
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| | DNA Repair |
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| Group | nucleic acid binding |
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