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Checkpoint Signaling and DNA Repair Pathway: PCNA
 | | |  PCNA Antibodies
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| Anti-PCNA (112-121) (Ab-1) Mouse mAb (PC10) |
IB, IF, NOT IP, PS |
human, mouse, rat, yeast |
NA03T |
| Anti-PCNA (247-261) (Ab-5) Rabbit pAb |
IP |
human |
PC474 |
| Anti-PCNA (Ab-1) Mouse mAb (PC10) |
IB, IF, NOT IP, PS |
human, mouse, rat, yeast |
NA03 |
| Anti-PCNA (Ab-1) Mouse mAb (PC10) Fluorescein Conjugate |
FC, IF |
human, mouse, rat, yeast |
NA03F |
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| | | PCNA Kits
| | | | Additional Information | | | | | | | | |
| Protein : PCNA
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| Connectivity | 500 |
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| Notes | The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. |
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| Hugo ID | 8729 |
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| Name | PCNA |
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| Description | proliferating cell nuclear antigen |
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| URN | urn:agi-llid:5111 |
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| GO Cellular Component | delta-DNA polymerase cofactor complex |
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| | nucleus |
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| | cyclin-dependent protein kinase holoenzyme complex |
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| | replication fork |
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| Cell Localization | Nucleus |
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| GO Biological Process | DNA replication |
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| | regulation of DNA replication |
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| | DNA repair |
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| | cell proliferation |
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| | regulation of cell cycle |
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| State Description | Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. |
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| | Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein. |
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| Alias | Pcna |
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| | PCNAR |
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| | proliferating cell nuclear antigen |
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| | MGC8367 |
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| | Cyclin |
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| | DNA polymerase delta auxiliary protein |
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| | PCNA_HUMAN |
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| | similar to proliferating cell nuclear antigen (Spodoptera frugiperda) |
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| Organism | Rattus norvegicus |
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| | Mus musculus |
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| | Human |
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| Group | nucleic acid binding |
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