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Checkpoint Signaling and DNA Repair: RAD1
 | | | Currently we do not offer any products for RAD1 . Please check back soon.
For additional information on this protein, please refer to the general information provided below. | | | | | | |
| Protein : RAD1
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| Connectivity | 48 |
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| Notes | The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad1, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein has been shown to associate with RAD9 and HUS1 proteins, and forms a cell cycle checkpoint complex. The complex can be recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Three alternatively spliced transcript variants, which encode two distinct proteins, have been reported. |
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| Hugo ID | 9806 |
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| Name | RAD1 |
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| Description | RAD1 homolog (S. pombe) |
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| URN | urn:agi-llid:5810 |
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| GO Cellular Component | nucleus |
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| Cell Localization | Nucleus |
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| GO Biological Process | DNA repair |
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| | cell cycle checkpoint |
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| State | RAD1 homolog isoform 1 |
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| | RAD1 homolog isoform 2 |
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| State Description | Transcript Variant: This variant (1) contains an extra region absent in variant 2, and thus encodes a protein that has a longer N-terminus, as compared to isoform 2. |
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| | Transcript Variant: This variant (2) lacks an internal fragment within the coding region, which results in a translation frame shift when compared to variant 1. The translation begins at a down-stream start codon, and thus results in an N-terminal trun... |
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| | Transcript Variant: This variant (3) contains a different 5' end UTR region when compared to variant 1. The encoded protein is identical to that encoded by variant 1. |
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| Alias | Rad1 |
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| | RAD1 homolog (S. pombe) |
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| | HRAD1 |
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| | Rad1-like protein |
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| | DNA repair protein RAD1 |
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| | RAD1 (S. pombe) homolog |
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| | exonuclease homolog RAD1 |
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| | DNA repair exonuclease (REC1) |
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| | cell cycle checkpoint protein Hrad1 |
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| | cell cycle checkpoint protein rad1 A/B |
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| | Rad1-like DNA damage checkpoint protein |
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| | cell cycle checkpoint protein Hrad I |
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| | DNA repair protein RAD I |
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| | exonuclease homolog RAD I |
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| | HRAD I |
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| | RAD1 homolog |
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| | RAD1 homolog isoform 1 |
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| | RAD1 homolog isoform 2 |
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| | RAD1 homolog isoform I |
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| | RAD1 homolog isoform II |
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| | similar to Rad1p |
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| Organism | Mus musculus |
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| | Human |
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| Group | nucleic acid binding |
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