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Checkpoint Signaling and DNA Repair: RAD17
 | | |  RAD17 Antibodies
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| Anti-Rad17 (Ab-1) (2-15) Rabbit pAb |
IB |
human |
PC614 |
| PhosphoDetect™ Anti-Rad17 (pSer645) Rabbit pAb |
IB |
human |
DR1013 |
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| | | | Additional Information | | | | | | | | |
| Protein : RAD17
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| Connectivity | 98 |
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| Notes | The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by ATR after the damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. |
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| Hugo ID | 9807 |
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| Name | RAD17 |
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| Description | RAD17 homolog (S. pombe) |
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| URN | urn:agi-llid:5884 |
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| GO Cellular Component | DNA replication factor C complex |
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| | nucleus |
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| Cell Localization | Nucleus |
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| GO Biological Process | DNA damage checkpoint |
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| | DNA repair |
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| | DNA replication |
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| | DNA replication checkpoint |
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| | cell cycle |
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| | mitotic checkpoint |
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| State | RAD17 homolog isoform 1 |
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| | RAD17 homolog isoform 2 |
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| | RAD17 homolog isoform 3 |
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| | RAD17 homolog isoform 4 |
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| State Description | Transcript Variant: This variant (8) contains a different 5' end region, and lacks an internal 5' UTR region, when compared to variant 1. The encoded protein is identical to that encoded by variant 1. |
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| | Transcript Variant: This variant (1) encodes the longest isoform (1). |
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| | Transcript Variant: This variant (2) lacks an fragment at the 5' end of the coding region, when compared to variant 1. The resulting protein contains an unique 14 aa N-terminus, as compared to isoform 1. |
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| | Transcript Variant: This variant (3) lacks an internal fragment at the 5' end of the coding region, when compared to variant 1. The translation begins at a downstream start codon, and thus results in an N-terminal truncated protein, as compared to isof... |
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| | Transcript Variant: This variant (4) lacks an internal 5' UTR region, as well as an internal fragment within the coding region, when compared to variant 1. It thus encodes a protein that lacks a 86 aa internal segment at the N-terminal region, as compa... |
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| | Transcript Variant: This variant (5) lacks an internal 5' UTR region when compared to variant 1. The encoded protein is identical to that encoded by variant 1. |
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| | Transcript Variant: This variant (6) contains a different 5' end region, and lacks an internal 5' UTR region, when compared to variant 1. The encoded protein is identical to that encoded by variant 1. |
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| | Transcript Variant: This variant (7) lacks an internal 5' UTR region when compared to variant 1. The encoded protein is identical to that encoded by variant 1. |
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| Alias | Rad17 |
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| | MmRad24 |
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| | RAD17 homolog (S. pombe) |
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| | 9430035O09Rik |
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| | CCYC |
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| | R24L |
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| | Rad24 |
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| | HRAD17 |
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| | RAD17Sp |
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| | Rad17-like protein |
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| | RAD1 (S. pombe) homolog |
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| | RF-C activator 1 homolog |
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| | cell cycle checkpoint protein (RAD17) |
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| | PIR:T34548 |
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| | Cell cycle checkpoint protein Rad17 |
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| | DKFZP434A1135 |
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| | RAD17 homolog |
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| | RAD17 homolog isoform 1 |
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| | RAD17 homolog isoform 2 |
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| | RAD17 homolog isoform 3 |
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| | RAD17 homolog isoform 4 |
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| | RAD17 homolog isoform I |
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| | RAD17 homolog isoform II |
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| | RAD17 homolog isoform III |
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| | RAD17 homolog isoform IV |
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| | RIKEN cDNA 9430035O09 gene |
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| | similar to RF-C/activator 1 homolog |
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| Organism | Mus musculus |
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| | Human |
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| Group | nucleotide binding |
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| | nucleic acid binding |
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