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Checkpoint Signaling and DNA Repair: RAD50
 | | |  RAD50 Antibodies
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| Anti-Rad50 Mouse mAb (2C6) |
IB, IP |
human |
552140 |
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| | | | Additional Information | | | | | | | | |
| Protein : RAD50
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| Connectivity | 60 |
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| Notes | The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. |
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| Hugo ID | 9816 |
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| Name | RAD50 |
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| Description | RAD50 homolog (S. cerevisiae) |
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| URN | urn:agi-llid:10111 |
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| GO Cellular Component | membrane |
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| | Mre11 complex |
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| Cell Localization | Nucleus |
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| GO Biological Process | DNA repair |
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| | transport |
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| | double-strand break repair |
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| | meiotic recombination |
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| | regulation of mitotic recombination |
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| | telomerase-dependent telomere maintenance |
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| State | RAD50 homolog isoform 1 |
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| | RAD50 homolog isoform 2 |
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| State Description | Transcript Variant: This variant (1) contains an internal region absent in variant 2. The resulting protein is 139 aa longer at its N-terminus, as compared to isoform 2. |
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| | Transcript Variant: This variant (2) lacks an internal fragment, which leads to a translation frame shift when compared to variant 1. Translation begins at a down-stream start codon, and thus results in a protein that is 139 aa shorter at its N-terminu... |
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| Alias | Rad50 |
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| | RAD50 homolog (S. cerevisiae) |
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| | Mrell |
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| | Rad50l |
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| | hRad50 |
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| | RAD50-2 |
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| | RAD50 (S. cerevisiae) homolog |
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| | RAD50 homolog |
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| | RAD50 homolog isoform 1 |
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| | RAD50 homolog isoform 2 |
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| | RAD50 homolog isoform I |
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| | RAD50 homolog isoform II |
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| | RAD50 II |
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| Organism | Rattus norvegicus |
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| | Mus musculus |
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| | Human |
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| Pathway | ATM signaling |
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| | DNA Repair |
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| Group | nucleotide binding |
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| | hydrolase activity |
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