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Checkpoint Signaling and DNA Repair: RAD51
 | | |  RAD51 Antibodies
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| Anti-Rad51 (Ab-1) Rabbit pAb |
FS, IB, IP, PS |
human |
PC130 |
| Anti-Rad51 (Ab-1) Rabbit pAb |
FS, IB, IP, PS |
human |
PC130T |
| Anti-Rad51 (Ab-2) Mouse mAb (51RAD01) |
IB, IP, PS |
human |
NA71 |
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| | | RAD51 Proteins
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| RAD51, His•Tag®, Human, Recombinant, E. coli |
553504 |
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| | | | Additional Information | | | | | | | | |
| Protein : RAD51
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| Connectivity | 249 |
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| Notes | The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. Transcript variants utilizing alternative polyA signals exist. |
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| Hugo ID | 9817 |
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| Name | RAD51 |
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| Description | RAD51 homolog (S. cerevisiae) |
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| URN | urn:agi-llid:5888 |
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| GO Cellular Component | condensed chromosome |
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| | condensed nuclear chromosome |
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| | nucleus |
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| | synaptonemal complex |
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| Cell Localization | Nucleus |
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| GO Biological Process | DNA recombination |
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| | DNA repair |
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| | meiosis |
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| | DNA unwinding |
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| | cell growth and/or maintenance |
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| | double-strand break repair via homologous recombination |
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| | meiotic recombination |
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| | mitotic recombination |
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| | positive regulation of DNA ligation |
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| State | RAD51 homolog protein isoform 1 |
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| | RAD51 homolog protein isoform 2 |
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| State Description | Transcript Variant: This variant (1), which encodes isoform 1, is the full-length transcript. |
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| | Transcript Variant: This variant (2) lacks a segment within the coding region when compared to variant 1. The translation remains in-frame, and thus the encoded isoform (2) lacks a 97 aa internal segment, as compared to isoform 1. |
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| Alias | Rad51 |
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| | Reca |
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| | Rad51a |
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| | RAD51 homolog (S. cerevisiae) |
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| | HRAD51 |
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| | HsRad51 |
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| | RA51 |
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| | RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) |
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| | RecA-like protein |
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| | recombination protein A |
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| | RecA, E. coli, homolog of |
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| | DNA repair protein RAD51 homolog 1 |
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| | RAD51, S.cerevisiae, homolog of, A |
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| | RAD51 (S. cerevisiae) homolog (E coli RecA homolog) |
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| | RA51_HUMAN |
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| | RAD51 protein homolog |
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| | HsT16930 |
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| | DNA repair protein RAD51 homolog I |
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| | DNA-recombinase |
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| | RAD51 homolog |
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| | RAD51 homolog (RecA homolog, E. coli) |
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| | RAD51 homolog protein isoform 1 |
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| | RAD51 homolog protein isoform 2 |
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| | RAD51 homolog protein isoform I |
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| | RAD51 homolog protein isoform II |
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| | RAD51, S.cerevisiae, homolog of A |
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| | similar to RAD51 homolog |
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| | similar to RAD51-like protein |
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| | DNA repair homolog 1 |
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| | similar to RAD51 homolog (S. cerevisiae) |
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| Organism | Mus musculus |
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| | Human |
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| Pathway | ATM signaling |
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| | DNA Repair |
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| Group | nucleotide binding |
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| | protein binding |
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| | nucleic acid binding |
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