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Interactive Pathways
Checkpoint Signaling & DNA Repair
Checkpoint Signaling and DNA Repair: RFC
 

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For additional information on this protein, please refer to the general information provided below.

 
 
 

Protein : RFC1

SwissProt Accessions | Entrez Gene links

Connectivity 16
Notes The protein encoded by this gene is the large subunit of replication factor C, which is a five subunit DNA polymerase accessory protein. Replication factor C is a DNA-dependent ATPase that is required for eukaryotic DNA replication and repair. The protein acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It also may have a role in telomere stability.
Hugo ID 9969
Name RFC1
Description replication factor C (activator 1) 1, 145kDa
URN urn:agi-llid:5981

GO Cellular Component DNA replication factor C complex
intracellular
nucleus

Cell Localization Nucleus

GO Biological Process DNA replication
regulation of transcription, DNA-dependent
DNA-dependent DNA replication
telomerase-dependent telomere maintenance

MGI ID 97891

Swiss-Prot Accession  P35251

OMIM ID OMIM:102579

Alias Recc1
Rfc1
replication factor C
140kDa
Alp145
RFC140
replication factor C 1
replication factor C, 140 kDa
A1
RFC
PO-GA
MHCBFB
p140
replication factor C (activator 1) 1, 145kDa
replication factor C1
MHC binding factor, beta
replication factor C (activator 1) 1 (145kD)
replication factor C large subunit
MGC51786
A1 140 kDa subunit
Activator 1 140 kDa subunit
Activator 1 large subunit
DNA-binding protein PO-GA
LOC310530
RECC I
RF-C 140 kDa subunit
MHC binding factor

Organism Rattus norvegicus
Mus musculus
Human

Entrez ID  89809
19687
5981
10372

RGD ID 620619

Pathway DNA Repair

Unigene ID Rn.103272
Mm.148877
Hs.166563

Group nucleotide binding
nucleic acid binding