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Checkpoint Signaling and DNA Repair: SMC1
 
SMC1 Antibodies
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Anti-SMC1 Rabbit pAb IB, IF, IP human PC737
 
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Protein : SMC1

SwissProt Accessions | Entrez Gene links

Connectivity 62
Notes Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation.
Hugo ID 11111
Name SMC1
Description SMC1 structural maintenance of chromosomes 1-like 1 (yeast)
URN urn:agi-llid:8243
GO Cellular Component membrane
nucleus
cohesin core heterodimer
kinetochore
Cell Localization Nucleus
GO Biological Process DNA repair
cell cycle
chromosome segregation
meiosis
mitosis
transport
DNA damage response, signal transduction
cell cycle checkpoint
mitotic sister chromatid cohesion
mitotic sister chromatid segregation
mitotic spindle assembly
response to radiation
MGI ID 1344345
Swiss-Prot Accession  Q14683
OMIM ID OMIM:300040
Alias Smc1l1
SB1.8
SMC-like 1 (yeast)
DXhXs423e
segregation of mitotic chromosomes-like 1
SMC (segregation of mitotic chromosomes 1)-like 1 (yeast)
SMC1 structural maintenance of chromosomes 1-like 1
KIAA0178
SMCB
Smc1
SMC (structural maintenance of chromosomes 1)-like 1 (S. cerevisiae)
chromosome segregation protein SmcB
segregation of mitotic chromosomes b
Smc1alpha
5830426I24Rik
DXS423E
SMC1 structural maintenance of chromosomes 1-like 1 (yeast)
segregation of mitotic chromosomes 1
SMC1 (structural maintenance of chromosomes 1, yeast)-like 1
chromosome segregating protein SmcB
SB18
segregating of mitotic chromosomes 1
segregating of mitotic chromosomes b
segregating of mitotic chromosomes I
segregating of mitotic chromosomes-like 1
segregating of mitotic chromosomes-like I
Segregation of mitotic chromosomes 1 (SMC1, yeast human homolog of,
segregation of mitotic chromosomes I
segregation of mitotic chromosomes-like I
SMC (segregating of mitotic chromosomes 1)-like 1
SMC (segregating of mitotic chromosomes 1)-like I
SMC (segregation of mitotic chromosomes 1)-like 1
SMC (structural maintenance of chromosomes 1)-like 1
SMC I
SMC1(alpha)
Smc1l I
SMC-like 1
SMC-like I
(structural maintenance of chromosomes 1, yeast)-like
Segregation of mitotic chromosomes 1 (SMC1, human homolog of
Organism Rattus norvegicus
Mus musculus
Human
Entrez ID  25185
63996
24061
56385
67766
80490
8243
RGD ID 61991
Pathway DNA Repair
Unigene ID Rn.11763
Mm.26412
Hs.211602
Group nucleotide binding
protein binding
nucleic acid binding
hydrolase activity
 
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