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Checkpoint Signaling and DNA Repair: p53
 
p53
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p53 (1-342, C-Terminal Deletion), His•Tag®, Human, Recombinant, S. frugiperda 506146
p53, MDM-2 Binding Domain, N-Terminal 17-26, Cell-Permeable 506136
p53, Wild-Type, His•Tag®, Human, Recombinant, S. frugiperda 506147
 
p53 Antibodies
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Anti-p19ARF (54-75) Rat mAb (12-A1-1) IB, IF, IP mouse CB1013
Anti-p19ARF (54-75) Rat mAb (5-C3-1) IB, IF, IP, PS mouse CB1012
Anti-p53 (Ab-1) (Pantropic) Mouse mAb (PAb421) FC, FS, GS, IB, IF, IP human, monkey, mouse, rabbit, rat OP03
Anti-p53 (Ab-1) (Pantropic) Mouse mAb (PAb421) FC, FS, GS, IB, IF, IP human, monkey, mouse, rabbit, rat OP03L
Anti-p53 (Ab-1) (Pantropic) Mouse mAb (PAb421) FC, FS, GS, IB, IF, IP human, monkey, mouse, rabbit, rat OP03T
Anti-p53 (Ab-1) (Pantropic) Mouse mAb (PAb421) Fluorescein Conjugate FC, FS, IF human, monkey, mouse, rabbit, rat OP03F
Anti-p53 (Ab-11) (Pantropic) Mouse mAb (PAb1802) IB, IP, NOT FS, NOT IF, NOT PS human, mouse OP104L
Anti-p53 (Ab-12) (Pantropic) Mouse mAb (DO-7) FS, IB, IF, IP, PS bovine, human, monkey OP140
Anti-p53 (Ab-2) (Pantropic) Mouse mAb (PAb1801) FS, GS, IB, IP, PS human OP09
Anti-p53 (Ab-2) (Pantropic) Mouse mAb (PAb1801) FS, GS, IB, IP, PS human OP09L
Anti-p53 (Ab-2) (Pantropic) Mouse mAb (PAb1801) FS, GS, IB, IP, PS human OP09T
Anti-p53 (Ab-3) (Mutant) Mouse mAb (PAb240) FC, FS, GS, IB, IF, IP, PS bovine, chicken, hamster, human, mouse, rat OP29
Anti-p53 (Ab-3) (Mutant) Mouse mAb (PAb240) FC, FS, GS, IB, IF, IP, PS bovine, chicken, hamster, human, mouse, rat OP29L
Anti-p53 (Ab-4) (Wild type) Mouse mAb (PAb246) IC, IP, NOT IB, PS mouse, rat OP32
Anti-p53 (Ab-4) (Wild type) Mouse mAb (PAb246) IC, IP, NOT IB, PS mouse, rat OP32L
Anti-p53 (Ab-5) (Wild type) Mouse mAb (PAb1620) FS, IF, IP, NOT IB, PS bovine, human, mouse, primate, rat OP33
Anti-p53 (Ab-6) (Pantropic) Mouse mAb (DO-1) FS, IB, IC, IP, PS feline, human OP43
Anti-p53 (Ab-6) (Pantropic) Mouse mAb (DO-1) FS, GS, IB, IC, IP, PS feline, human OP43L
Anti-p53 (Ab-6) (Pantropic) Mouse mAb (DO-1) FS, IB, IC, IP, PS feline, human OP43T
Anti-p53 (Ab-6) (Pantropic) Mouse mAb (DO-1) Agarose Conjugate AC, IP feline, human OP43A
Anti-p53 (Ab-6) (Pantropic) Mouse mAb (DO-1) Fluorescein Conjugate FC, FS, IC, IF, PS feline, human OP43F
Anti-p53 (Ab-7) (Pantropic) Sheep pAb FS, IB, IF, IP, PS human, mouse, rat PC35
Anti-p53 (Ab-8) (Pantropic) Mouse mAb (BP53.12) FS, IB, IP, PS human, primate OP73
PhosphoDetect™ Anti-p53 (pSer15) (Ab-3) Rabbit pAb IB, IP human, mouse, rat PC386
PhosphoDetect™ Anti-p53 (pSer15) (Ab-3) Rabbit pAb FFS, IB, IC, IP, PS human, mouse, rat PC386T
PhosphoDetect™ Anti-p53 (pSer15) (Ab-6) Rabbit pAb IB, PS human PC461
PhosphoDetect™ Anti-p53 (pSer20) Rabbit pAb IB, IC, IF, PS human, mouse DR1023
PhosphoDetect™ Anti-p53 (pSer392) (Ab-4) Rabbit pAb IB human, mouse PC387
PhosphoDetect™ Anti-p53 (pSer392) Mouse mAb (9F4) ELISA, IB human, mouse 506133
PhosphoDetect™ Anti-p53 (pSer46) Rabbit pAb IB, IC, IP human DR1024
Anti-PARC (1-763) Rabbit pAb IB, IP human DR1040
 
p53 Activators
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MDM2 Inhibitor 444145
MDM2 Antagonist III 444149
MDM2 Antagonist, Nutlin-3, Racemic 444143
p53, MDM-2 Binding Domain, N-Terminal 17-26, Cell-Permeable 506136
p53 Activator, Cell-Permeable 506131
p53 Activator II, Cell-Permeable 506144
p53 Activator III, RITA 506149
PRIMA-1 530050
 
p53 Assay Kits
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PhosphoDetect™ p53 (pSer15) ELISA Kit CBA009
 
Additional Information
 
 
 
 

Protein : p53

SwissProt Accessions | Entrez Gene links

Connectivity 3212
Notes Tumor protein p53, a nuclear protein, plays an essential role in the regulation of cell cycle, specifically in the transition from G0 to G1. It is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing DNA-binding, oligomerization and transcription activation domains. It is postulated to bind as a tetramer to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome.
Hugo ID 11998
Name p53
Description transformation related protein 53
URN urn:agi-llid:7157
GO Cellular Component cytoplasm
cytosol
nucleus
mitochondrion
nucleolus
Cell Localization Nucleus
GO Biological Process DNA damage response, signal transduction by p53 class mediator
apoptosis
negative regulation of cell cycle
negative regulation of cell growth
protein-nucleus import, translocation
regulation of transcription from Pol II promoter
regulation of transcription, DNA-dependent
transcription
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
cell cycle
negative regulation of DNA replication
negative regulation of apoptosis
negative regulation of fibroblast proliferation
regulation of cell proliferation
response to DNA damage stimulus
response to UV
response to X-ray
caspase activation via cytochrome c
cell aging
cell cycle arrest
cell cycle checkpoint
cell differentiation
cell proliferation
induction of apoptosis by hormones
negative regulation of helicase activity
nucleotide-excision repair
regulation of mitochondrial membrane permeability
MGI ID 98834
Swiss-Prot Accession  P04637
OMIM ID OMIM:191170
OMIM:202300
OMIM:114480
OMIM:114500
OMIM:114550
OMIM:151623
OMIM:161550
OMIM:260350
Alias Tp53
p53
Trp53
tumor protein p53 (Li-Fraumeni syndrome)
transformation related protein 53
P53_HUMAN
cellular tumor antigen p53
Phosphoprotein p53
similar to p53 alternative splice isoform p35/HAS
similar to transformation related protein 53
tumor protein p53
Tumor suppressor p53
P-53
Organism Rattus norvegicus
Mus musculus
Human
Entrez ID  24842
22059
7157
RGD ID 3889
Pathway RB Tumor Suppressor
SAPK-JNK Signaling
Mitochondrial control of Apoptosis
p53 Signaling
ATM signaling
Apoptosis
GSK3 50
GSK3
AKT signaling
DNA Repair
PL AKT signaling
'GSK3 50' plus
Unigene ID Rn.54443
Mm.222
Hs.408312
Group Transcription factors
nucleotide binding
metal ion binding
 
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