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Akt Interactive Pathway: Akt
 | | |  Akt Antibodies and Blocking Peptides
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| Anti-Akt, PH Domain Mouse mAb (SKB1) |
FC, IB, IP |
human, mouse, rat |
ST1088 |
| Anti-Akt1 (Ab-1) (135-145) Rabbit pAb |
IC, NOT IB, NOT PS |
human, mouse |
PC510 |
| Anti-Akt1 (88-100) Rabbit pAb |
ELISA, IB, IP |
human, mouse, rat, Xenopus |
530311 |
| PhosphoDetect™ Anti-Akt1 (pSer473) Mouse mAb (11E6) |
ELISA, IB |
human, mouse |
124003 |
| PhosphoDetect™ Anti-Akt1 (pThr308) Rabbit pAb |
IB |
human, mouse |
124001 |
| Anti-Akt2 Rabbit pAb |
ELISA, IB |
human, mouse, rat |
124002 |
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| | | Akt Assay Kits
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| Akt Activity Immunoassay Kit |
124007 |
| K-LISA™ Akt Activity Kit |
CBA019 |
| PhosphoDetect™ Akt (pSer473) ELISA Kit |
CBA005 |
| PhosphoDetect™ Akt (pThr308) ELISA Kit |
CBA004 |
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| | | Akt Inhibitors
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| Akt Inhibitor |
124005 |
| Akt Inhibitor II |
124008 |
| Akt Inhibitor III |
124009 |
| Akt Inhibitor IV |
124011 |
| InSolution™ Akt Inhibitor IV |
124015 |
| Akt Inhibitor V, Triciribine |
124012 |
| Akt Inhibitor VI, Akt-in |
124013 |
| Akt Inhibitor VII, TAT-Akt-in |
124014 |
| Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 |
124018 |
| InSolution™ Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 |
124017 |
| Akt Inhibitor IX, API-59CJ-OMe |
124019 |
| Akt Inhibitor X |
124020 |
| Akt Inhibitor XI |
124028 |
| (-)-Deguelin, Mundulea sericea |
252740 |
| PDK1/Akt/Flt Dual Pathway Inhibitor |
521275 |
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| | | Akt Substrates/Enzymes
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| Akt1, His•Tag®, Activated, Human, Recombinant, S. frugiperda |
124006 |
| Akt2, GST-Fusion Protein, Human, Recombinant, S. frugiperda |
124021 |
| Akt3, GST-Fusion Protein, Human, Recombinant, S. frugiperda |
124022 |
| AKTide-2T |
123900 |
| PKBa Substrate |
539622 |
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| | | | Additional Information | | | | | | | | |
| Protein : AKT1
| | |
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| Connectivity | 3339 |
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| Notes | The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. |
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| Hugo ID | 391 |
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| Name | AKT1 |
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| Description | thymoma viral proto-oncogene 1 |
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| URN | urn:agi-llid:207 |
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| | |
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| GO Cellular Component | cytoplasm |
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| | lamellipodium |
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| | nucleus |
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| | |
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| Cell Localization | Cytoplasm |
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| | Nucleus |
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| GO Biological Process | anti-apoptosis |
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| | positive regulation of cell growth |
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| | protein amino acid phosphorylation |
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| | signal transduction |
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| | apoptosis |
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| | apoptotic mitochondrial changes |
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| | cell growth and/or maintenance |
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| | germ cell development |
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| | protein catabolism |
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| | protein ubiquitination |
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| | regulation of cell cycle |
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| | G-protein coupled receptor protein signaling pathway |
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| | nitric oxide biosynthesis |
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| | response to heat |
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| | |
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| Alias | Akt1 |
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| | Akt |
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| | v-akt murine thymoma viral oncogene homolog 1 |
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| | thymoma viral proto-oncogene |
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| | RAC protein kinase alpha RAC-PK alpha |
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| | murine thymoma viral (v-akt) oncogene homolog 1 |
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| | PKB |
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| | PKB/Akt |
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| | PKBalpha |
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| | thymoma viral proto-oncogene 1 |
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| | RAC |
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| | PRKBA |
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| | KRAC |
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| | Murine thymoma viral (v-akt) oncogene homolog-1 |
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| | serine/threonine protein kinase |
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| | KRAC_HUMAN |
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| | Akt1/PKB protein kinase |
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| | RAC-ALPHA |
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| | Akt I |
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| | Akt/PKB |
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| | AKTI |
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| | C-AKT |
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| | Murine thymoma viral (v-akt) oncogene homolog I |
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| | PKB alpha |
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| | Protein kinase B |
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| | RAC-alpha serine/threonine kinase |
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| | RAC-PK-alpha |
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| | serine/threonine protein kinase B |
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| | thymoma viral proto-oncogene I |
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| | v-akt murine thymoma viral oncogene homolog I |
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| | |
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| Organism | Rattus norvegicus |
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| | Mus musculus |
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| | Human |
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| | |
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| Pathway | ACH-R in apoptosis |
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| | AKT signaling |
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| | Inhibition of Apoptosis |
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| | Insulin Receptor Signaling |
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| | Jak-Stat Pathway from IL6 Receptor |
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| | PTEN signaling |
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| | CREB signaling |
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| | Antiapoptotic Pathways From IGF-1R |
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| | Mitochondrial control of Apoptosis |
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| | Apoptosis |
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| | AKT signaling |
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| | MyCopy of 'ATM signaling' |
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| | NFkB |
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| | NFkB1 expanded |
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| | IKB-NFkB |
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| | |
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| Group | Kinases |
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| | nucleotide binding |
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