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Antibodies that target the mTOR pathway
 | | | | mTOR (mammalian Target of Rapamycin) was originally identified in Saccharomyces cerevisiae where mutations of the protein kinase, TOR, confer rapamycin resistance. mTOR is a large (>250 kDa) class IV PI-3 kinase family member with protein kinase activity, but lacks any lipid kinase activity. mTOR acts to integrate mitogenic and nurtient signals to regulate cell growth, metabolism, and survival. The details of how mTOR carries out these functions is not well understood. | | |  | Detection of mTOR by immunoblotting.
Sample: Whole cell lysate (50 mg) from HEK293 cells. Primary antibody: Anti-mTOR/FRAP (Ab-2) Mouse mAb (Cat. No. OP97) (2 mg/ml). Detection: chemiluminescence |
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| Anti-AMPKa-2 Rabbit pAb |
IB, IP |
bovine, human, rat |
ST1089 |
| Anti-LKB1 (120-160) Rabbit pAb |
IB |
human |
ST1092 |
| PhosphoDetect™ Anti-mTOR (pSer2448) Rabbit pAb |
IB |
human |
PS1020 |
| Anti-mTOR/FRAP (Ab-2) Mouse mAb (22C2) |
IB, IP |
human |
OP97 |
| Anti-p70S6 Kinase Rabbit pAb |
IB |
human, mouse, rat |
ST1046 |
| PhosphoDetect™ Anti-p70S6K(pThr389) Rabbit pAb |
ELISA, IB |
human |
PK1015 |
| Anti-PTEN Mouse mAb (EMD-4B8) |
IB, NOT IP |
human |
AP1042 |
| Anti-PTEN Mouse mAb (EMD-15E10) |
ELISA, IP, NOT IB |
human |
AP1041 |
| PhosphoDetect™ Anti-PTEN (pSer380) Rabbit pAb |
IB, IC, IP, PS |
human, mouse, rat |
ST1072 |
| Anti-Raptor Rabbit pAb |
IB |
human, mouse, rat |
ST1048 |
| Anti-TSC1 (Tuberous Sclerosis 1) Rabbit pAb |
IB, IP |
human, mouse |
AP1032 |
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| | | | | | Related Links | | mTOR Signaling Interactive Pathway | | K-LISA™ mTOR Activity Kit | | |
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