Lead Article: "TGF-b signaling in tumor suppression and oncogenesis"

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Lead Article: "PI 3-Kinase: A Multifunctional Signaling Molecule"

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Lead Article: "Poly(ADP-ribosylation) - PARP in DNA Repair and Apoptosis"

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Lead Article: "Cancer Stem Cells: The Real Perpetrators in Cancer Growth and Progression"

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Lead Article: "NF-kB Activation: A Link Between Chronic Inflammation and Cancer"

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Lead Article: "Diabetes, Insulin Resistance, and the Metabolic Syndrome X"

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Lead Article: "Glycogen Synthase Kinase-3: Its Signaling Role in Development and Disease "

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Lead Article: "Akt/PI 3-Kinase Signaling in Cell Death & Cell Survival"

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Lead Article: "Tubulin Polymerization and Depolymerization: Exploiting the Dynamic Instability of Microtubules"

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Lead Article: "NF-KB - A Therapeutic Target for Inflammation and Cancer"

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Lead Article: "Cell Cycle Checkpoints: Molecular Targets for Cancer Chemotherapy"

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Lead Article: "Nuclear Import/Export: A Nuclear Revolving Door."

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Lead Article: Defective Insulin Signaling in Diabetes. Includes many new products in the areas of Diabetes, Angiogenesis, Cell Cycle, Parkinson's Disease, Alzheimer's Disease, and features some exciting new kits for Proteomics Research.

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Lead article: Protein Tyrosine Kinases: Rational Targets for Cancer Therapy. Features new products in the areas of Protein Tyrosine Kinases, Alzheimer's Disease, Protein Ubiquitination, and Apoptosis.

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Lead Article: Alzheimer's Disease: Misguided Slicing of Amyloid Precursor Protein by Sectretases. Our newest products for Alzheimer's, protein kinase, apoptosis, cell cycle, nitric oxide/oxidative stress research and more!

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Lead Article: Apoptosis: Mitochondrial Intermembrane Proteins - The Beginner's of the End. Features products in the areas of Apoptosis, Cell Cycling, G-Protein Research, Calcium Signaling Tools, Neurochemicals and much more.

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Lead Article: Oxidative Stress: A Causative Factor in the Pathogenesis of Alzheimer's Disease. Features over 140 NEW biochemical and immunochemical reagents, including secretase inhibitors and substrates, c-Raf kinase inhibitors, amine and carbohydrate modifying reagents, phosphatase inhibitor cocktail sets, over 60 antibodies, and much more.

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Lead Article: Tumor Metastasis: Role of Cell Adhesion and Matrix Metalloproteases. Features over 120 biochemical and immunochemical reagents for cell adhesion, tumor metastasis, nitric oxide, protein kinases, caspases, apoptosis, glycobiology-related research, and much more. Includes our comprehensive Protein Kinases product guide, featuring over 600 products.

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Lead article: "Integrins, Molecular Adhesives in Cell Survival and Cell Death". Highlights of this issue include Integrin Detection Kits and Antibodies, Antibodies for Protein Degradation Research, Caspase Detection Kits, Antibodies for p53-Related Research, Calpain Assay Kits, Antibodies for Alzheimer's Disease Research, DNA Hypomethylation Reseach Tools, Antibodies and Kits for Angiogenesis Research, and Antibodies for Breast Cancer Markers.

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Lead article: "Oxidative Stress: More Than One Way to Die". Highlights of this issue include our New Kits for Apoptosis and PARP Detection, Tools for Apoptosis Research, DNA Repair and Research Tools, Nuclear Extracts and Tools for Angiogenesis Research.

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