Dowload Literature: Brochures and Technical Bulletins

Brochures I Technical Bulletins

Alzheimer's Research Tools and Technical Guide (CB0714)   We offer the industry's most complete line of Alzheimer's disease research tools. Included are antibodies, proteins, substrates, and inhibitors in the areas of b-amyloids, Tau proteins, secretases, presenilins, prions, GSK-3, and much more. Also includes research tools for Parkinson's Disease, and extensive technical articles in several areas. View PDF Akt Brochure (CB0728)   The Akt/PI 3-kinase pathway is one of the major growth factor signaling pathways in the cell. This 11 page brochure gives a nice overview of this pathway and the importance that Akt plays in cell signaling. Included will be a product listing of antibodies, assay kits, substrates, a table of specific inhibitors with application information including a technical tips section on the use of these inhibitors, and a nice diagram of the AKT pathway to summarize the molecules role in cell death and survival. AKT is a very hot target for both industry as well as academia for customers studying apoptosis, cancer, and cell survival. View PDF Angiogenesis and Tumor Metastasis Brochure and Technical Guide (CB0717)     A comprehensive guide to products for the study of Angiogenesis and Tumor Metastasis. Includes kits and sets, promoters and inhibitors of angiogenesis, antibodies to angiogenesis promoters and inhibitors, Cathepsins, Enzymes and Proteins, MMP products and TIMPs products. Includes several technical articles. View PDF
Antibiotics Profiler (CB0709)
	This brochure offers more than 60 different types and grades of antibiotics. Antibiotics used for selection and other purposes are described by their mode of action. View PDF
Antibodies for Cancer Research (CB0718)
	This brand new guide conveniently categorizes and lists all of our antibodies and kits available for your research in cancer. Also included are several technical articles, and product highlights. View PDF
Antibody SourceBook™ Second Edition (CB0803)
	The new edition of the SourceBook provides convenient access to 3000 antibodies and related products. Products are described in tables that provide the applications and species reactivity information for the antibodies. Sections include: Primary Antibodies, Secondary Antibodies & Conjugates, and Antibody Support Products. View PDF
Biological Detergents (CB0733)
	This brochure offers guidelines for solubilization of membrane proteins, helps select tools for detergent removal, touches on detergent usage basics, and includes 115 products. View PDF
Buffers Booklet (CB0052)
	An exceptional guide for the preparation and use of buffers in biological systems. Includes an in-depth overview of buffers and how they work, a guide on how to choose buffers, and a listing of buffers offered by Calbiochem. View PDF
Calcium Signaling Tools (CB0700)
	Newly updated comprehensive offering of the industry's best calcium chelators, ionophores channel modulators, and probes. We also have tools for understanding calcium dependent signaling processes, such as antagonists and inhibitors of calcium dependent pathways, and antibodies to proteins involved in calcium signaling. View PDF
Caspases and Other Apoptosis-Related Tools (CB0708)
	This newly updated product guide is the industry's most comprehensive offering of products for researchers working in the areas of Cancer and Apoptosis. Included are new telomerase-related products, proteasome-ubiquitin pathways products, antibodies, assay kits, enzymes, substrates, activators, inhibitors, and much more! View PDF
The Complement System(CB0617)
	This new product guide features all of our high quality complement reagents. A technical overview of the complement system is also included for your reference. View PDF
Detergents Booklet (CB0068)
	An excellent guide to the properties and uses of detergents in Biology and Biochemistry. Includes an overview of how detergents work, how they are classified, general properties of detergents, guidelines for choosing a detergent, and a listing of detergents which Calbiochem offers. Also provides a selected bibliography for both the general properties of detergents and detergent-specific references. View PDF
Diabetes and Obesity Brochure   View PDF   Extracellular Matrix Proteases Technical Guide (CB0707)   Calbiochem's complete line of MMPs, TIMPs, Cathepsins, Structural Proteins with related proteins, antibodies, inhibitors, substrates, and more! Also features a sneak preview of our growing Angiogenesis product line. View PDF   Glycobiology Brochure and Technical Guide (CB0712)   The new 12 page Calbiochem brochure has a comprehensive collection of research products used in glycobiology research. The brochure includes several products under the following topics: Cell adhesion assay kits, glycan labeling kits, enzymes, antibodies for glycobiology research, substrates, sugars, lipopolysaccharides, and carbohydrate-protein interaction tools. This area of research has recently gained importance as new discoveries of the critical biological functions that carbohydrates play a role in, have been identified. Carbohydrates are currently in clinical trials for treatment of a lot of diseases including inflammation and tissue rejection as well as hepatitis and cancer. There are a number of major pharmaceutical companies trying to develop carbohydrate-based cancer drugs indicating the health importance of these sugars. View PDF
Inhibitor SourceBook™ (CB0721)
	This valuable resource represents the most comprehensive listing of inhibitors (over 1200) for the following areas of research: Phosphorylation/Dephosphorylation, Apoptosis, Cell Division/Cell Cycle/Cell Adhesion, Lipid Signaling, Neurobiology/Neurodegeneration, Nitric Oxide/Oxidative Stress, Proteases, Other Inhibitors of Biological Interest, Short Technical Articles View PDF
p21 Family Brochure (LIT507)   This brochure features our p21WAF1 family with product and technical information. Also features our PCNA Kit - the best in the market! View PDF p53 Family Brochure (LIT506)   This product guide features our complete line of p53 and related products for your cancer research. Includes assay kits, antibodies, and inhibitors. View PDF       p53 and Related Products (CB0725)   p53 is a tumor suppressor protein that is activated following DNA damage, ultraviolet light, and treatment with chemotherapeutic agents. It is also one of the most frequently mutated genes in cancer. Under normal conditions p53 levels are kept low because of its rapid degradation in the ubiquitin-proteasome pathway. p53 can also act as a transcription factor to help regulate cell cycle progression and apoptosis. This flyer details the many antibodies available to study p53 and the many proteins it interacts with. p53 is the current focus of active research to understand it regulation and activation in health and disease. View PDF   Protein Kinase Assay and Detection Kits Brochure (CB0726)   The Protein Kinase Assay and Detection Kits brochure is a 12-page selection guide for all of our kits, ranging from our ELISA kinase detection kits to our homogeneous TruLight assays. Our strength in this area is the breadth of our kinase kit product line as well as complementary products such as kinase inhibitors, antibodies, enzymes, and substrates. The brochure explains the different formats of each group of kits and when to use them. For each group of kits, comparison tables are provided, allowing you to quickly assess important features of each kit. Technical tips for using the kits are also included. View PDF   New Research Tools for Signal Transduction & Life Science Research (CB0920)   This brochure is a list of all new Calbiochem products introduced since January 1, 2005. It includes products under the following topics: Alzheimer's Disease, Angiogenesis, Apoptosis, Cancer/Cell Cycle, Diabetes, DNA Damage & Repair, Heat Shock Proteins, Hormones, Growth Factors, & Cytokines, Membrane Trafficking, Neurobiology, Oxidative Stress, Proteases/Protease Inhibitors, Proteasome/Signalosome, Protein Kinases, Protein Phosphatases, and Transcription Factors. View PDF
Nitric Oxide & Oxidative Stress Research Tools (CB0703)
	This newly updated product guide is the industry's most comprehensive offering of products for researchers working in the areas of Nitric Oxide and Oxidative Stress, including cardiovascular diseases, aging, inflammation, and autoimmune disorders. This guide contains over 370 products, featuring NEW antibodies, enzymes, inhibitors, donors, substrates, and much more. View PDF
PhosphoDetect™ Phospho-specific Antibodies Brochure (CB0724)
	Features over 200 quality-tested phospho-specific antibodies and reagents for specific detection of phosphoproteins. Includes products for Serine/Threonine and Tyrosine Kinases, Apoptosis, Cancer, Cell Cycle, Cell Adhesion, Neurobiology, and more! Contains a special technical tips section with methods for optimizing phosphoprotein detection. View PDF
Protease and Phosphatase Inhibitor Cocktails Brochure (CB0734)
	Protease and phosphatase inhibitors (cocktails and individual inhibitors) are essential tools for researchers involved in proteomic studies including protein expression and characterization, biomarker discovery, mapping of post-translational modifications, protein expression profiling, and the quantitative measurement of proteins. Adding a protease inhibitor cocktail or protease inhibitor during preparative or purification steps helps ensure protein integrity for downstream analysis and sample characterization. For phosphorylated proteins, PhosphoSafe Extraction Reagent and phosphatase inhibitor cocktails help preserve their phosphorylation state in cell lysates and tissue extracts during extraction and purification steps. View PDF
Protein Kinases and Related Products (CB0702)
	A comprehensive listing of Protein Kinase research tools offered by Calbiochem. Includes antibodies, inhibitors, substrates, proteins and kits for your research needs. Also provides charts, graphs, and technical overviews of several pathways. View PDF
Proteasome/Ubiquitination & NF-kB Pathway (CB0723)
	This brochure includes several products under the following topics: Assay kits for Proteasome/Ubiquitin Research, Antibodies for Proteasome/Ubiquitin Research, Proteasome activators and Substrates, Proteasome and Ubiquitinaion Inhibitors, Ubiquitination Enzymes, Antibodies for the NF-kB Pathway Research, NoShift™ Transcription Factor Assay kit, NF-kB Activation Inhibitors and Fusion Tag Antibodies. This area of research has gained importance because of known abnormalities in the protein degradation pathway in tumors and development of multi-drug resistance. Proteasome inhibitors currently under clinical trials have shown promise in angiogenesis. Both proteasome and NF-kB are considered central to chronic inflammatory conditions as well as conditions such as rheumatoid arthritis and multiple sclerosis. View PDF
ProteoExtract™ Reproducible Protein Extraction Kits (CB0716)     Calbiochem is pleased to introduce a number of newly developed ProteoExtract™ Kits designed for fast and reproducible extraction of proteins from a wide range of sources including bacteria, yeast, tissue culture cells, and mammalian tissues. Different kits have been tailored to suit different protein separation needs. View PDF ProteoExtract™ Abundant Protein Removal Kits(CB0719)     ProteoExtract™ Abundant Protein Removal Kits provide highly specific and efficient depletion of either albumin alone or albumin and IgG from body fluids such as plasma or serum. Sample complexity is significantly reduced, enabling the detection of less abundant proteins. This brochure provides graphs, blots, and an in depth overview of these kits. View PDF
Second Messengers and Phosphoproteins Research Tools (CB0704)
	A comprehensive selection of hundreds of antibodies, enzymes, activators, inhibitors, substrates, calcium channel modulators, inositol phosphates and much more. View PDF
S-PEK Brochure
	Protein Sample Preparation Tools for Signal Transduction Research & Proteomics View PDF
Tools & Tips for Analyzing Apoptosis (CB0729)
	This 36-page brochure is organized by cellular location affected by apoptosis, with each section offering introductory information, a list of applicable products, and Technical Tips and Frequently asked Questions. The brochure Appendix features 4 Product Tables and 3 Technical Protocols. View PDF
Technical Bulletins:
Activators and Inhibitors of Adenylate Cyclase (CB0528) - A complete listing of our Cholera Toxin and Pertussis Toxin-related products, Forskolin analogs, inhibitors of adenylate cyclase, and more. This bulletin includes product comparisons, structures, and references.
Antibodies for Neurobiology Research (CB0544) - Includes information on antibodies for nitric oxide research, antibodies to porins, neurotoxins, and several enzymes and structural elements important in neuronal function and integrity.
Antibodies to GTP-Binding Proteins (CB0615) - Listing and product specifications for G-protein subunits and subunit antibodies, immobilized antibodies, and purified peptides.
Antibodies to Plasma and Serum Proteins (CB0598) - Lists all monoclonal and polyclonal antibodies to plasma and serum proteins currently available.
Bioactive Lipids (CB0549) - Provides an overview of the role of lipids in signal transduction. It also describes the cyclooxygenase and lipoxygenase pathways involved in the synthesis of various eicosanoids.
BLEOCIN™ (CB0558) - Detailed technical overview of a potent antibiotic for the selection of bleomycin resistance.
Bovine Serum Albumins/Human Serum Albumins (CB0593) - A handy chart with suggestions for various applications of serum albumins from bovine, human, and other species.
Caged Compounds (CB0595) - Our expanded line of caged compounds: neurotransmitters, calcium chelators, nucleotides, and inositol phosphates.
CALBIOSORB™ (CB0574) - Our excellent solution for detergent removal from your experimental mixtures. CALBIOSORB® is available as a slurry of beads or in convenient pre-packed columns. Includes a general usage protocol.
Calmodulin and Related Products (CB0587) - Our superior line of calmodulins from bovine and human sources as well as inhibitors of CaM-dependent protein kinases and CaM antagonists. Excellent references included.
Caspase Inhibitors and Substrates (CB0556) - A brief review with tables listing our innovative line of caspase inhibitors and substrates with useful application comments.
Cathepsins (CB0543) - A brief overview of our complete line cathepsins, substrates, inhibitors, and antibodies.
Channel Blockers (CB0537) - Sodium, potassium, calcium, and chloride channel blockers for your cardiovascular and neurochemical research. Includes excellent descriptions of selectivity and IC50 and/or Ki values.
Cleland's Reagent (Dithiothreitol) (CB0121) - Discusses the uses of DTT, a laboratory staple, as well as two newer fast-acting reducing agents - TCEP and BMS.
Coagulation Factors (CB0638) - Provides a schematic presentation of the coagulation process and lists our line of coagulation factors.
Complement (CB0617) - Descriptive lists of highly purified human complement components, monospecific antibodies to human complement component proteins, rabbit and guinea pig sera and complement-depleted human sera.
Detergents and Buffers (CB0603) - CALBIOCHEM's complete collection of high quality detergents and buffers with important general characteristic information.
Drugs for Selection of Genetic Markers (CB0613) - This bulletin includes the mechanism of action, working concentrations, and the stability of commonly used reagents for molecular cloning and stable expression of heterologous genes in prokaryotic or eukaryotic cells, as well as in generation of mammalian cell hybridomas.
Dyes and Stains (CB0607) - We offer dyes and stains for flow cytometry, chromosome and DNA staining, protein stains and tags, pH indicators, thiofluorescent reagents, tracers and other probes and viability stains.
Enzyme-Linked Detection Systems (CB0627) - Listing of a wide selection of peroxidase and alkaline phosphatase conjugated secondary antibodies, enzymes and substrates that are suitable for various immunochemical techniques.
Excitotoxic Glutamate Analogs (CB0521) - Outlines the mechanism of excitotoxicity and lists various excitotoxic products available.
Fluorescent Calcium Probes (CB0594) - Provides an overview of fluorescent probe technology and technical information on various probes available from CALBIOCHEM®.
Fluorochrome-Labeled Antibodies (CB0609) - Listing of rhodamine, fluorescein and Texas Red® conjugated secondary antibodies that are suitable for various immunochemical applications. The list also includes various fluorochromes available from CALBIOCHEM®.
Free Radical ELISA Assays (CB0245) - Describes our human lactoferrin, human myeloperoxidase, and human glutathione peroxidase ELISA kits.
Free Radical Marker Kits (CB0250) - Describes the principles underlying our spectrophotometric kits for assaying free radicals and oxidative stress.
Gangiosides (CB0614) - A brief overview of ganglioside research. Details our complete line of highly purified gangliosides. Also includes antibodies and enzymes for glycosphingolipid analysis.
Growth Factors and Cytokines (CB0605) - A general overview of growth factors and cytokines with a schematic diagram of their cellular effects. Colorful comparative table of recommended reconstitution, range-of-use, and storage information, along with comments on their properties and function.
Heat Shock Proteins and Antibodies (CB0535) - Provides an overview of the role of heat shock proteins in protein assembly and folding. Included are proteins and various antibodies.
Hydroxylapatite (CB0142) - CALBIOCHEM® offers two high quality grades of hydroxylapatite. In addition, this sheet discusses reagents available for immunoseparation.
Hygromycin B (CB0579) - Lists the biological applications and general properties of Hygromycin B with useful references.
Ionophores (CB0583) - Table of ionophores listing solubility, descriptions of the ion-specificity, and general uses of these products.
IPTG (CB0586) - Details our broad product line of IPTG, a carbohydrate used to regulate the expression og lac operator/reporter genes.
Keyhole Limpet Hemocyanins (CB0561) - Provides an overview of various hemocyanins and other proteins for hapten conjugation. Includes conjugation protocols and describes our kits for easy protein conjugation.
Lectins (CB0560) - Describes the most comprehensive line of lectins in the industry. Also lists our immobilized lectins for the affinity purification of glycoproteins and glycolipids and our carbohydrate affinity resins for purification of lectins, glycosidases, and glycosyltransferases. Includes a broad variety of neoglycoconjugates for specific lectin-binding studies.
Lipoproteins, Apolipoproteins, and Related Products (CB0523) - Presents a concise review of current knowledge of various lipoproteins , apolipoproteins, and a list of available antibodies to these proteins.
MAP Kinase Pathways Research Tools (CB0555) - CALBIOCHEM® provides the industry's most extensive line of products for studying MAP Kinase and related proteins, including purified enzymes, inhibitors, antibodies, activators, substrates, and an overview of MAP kinase pathways.
Molecular Biology Tools (CB0559) - A listing of our products with applications in molecular biology. Included in this bulletin is a selection of antibiotics, inhibitors of protein synthesis, and our latest molecular biology grade research products.
Neurotoxins (CB0576) - A useful consolidation of information on the properties and the mechanisms of action of over 100 neurotoxins and antibodies to neurotoxins. RECENTLY UPDATED - New Look!!
Nitric Oxide Donors and Scavengers (CB0562) - A comprehensive list of nitric oxide donors and precursors, as well as our line of nitric oxide scavengers.
Nitric Oxide: Activators, Inhibitors, and Substrates (CB0563) - Our industry-leading line of NOS activators and NO/NOS inhibitors. Also lists our probes for NO research, including the cell-permeable compound DAF-2DA.
Nitric Oxide: Enzymes, Antibodies, and Assay Kits (CB0564) - Lists our colorimetric and fluorometric assay kits for the detection of NO and NOS activity. Also includes our complete line of purified nNOS and iNOS enzymes and antibodies.
Nucleotides and Bases (CB0604) - Our complete line of nucleotides and bases including our caged nucleotides and nucleotide kits.
Paclitaxel and Other Anti-Neoplastic Agents (CB0584) - Excellent references and general information about Paclitaxel and a useful chart on our other anti-neoplastic agents.
Protease Inhibitors (CB0572) - A listing of our protease inhibitors with target protease class, general characteristics, and solubility information in an easy-to-use table format.
Proteases (CB0571) - An excellent laboratory reference source. Provides general comments on use and lists known inhibitors for these proteases.
Proteasomes (CB0557) - Provides a brief overview of the current understanding of the proteasome-ubiquitin protein degradation pathway. Includes enzymes, antibodies, substrates, and inhibitors.
Protein Kinases: Antibodies and Blocking Peptides (CB0567) - Our complete listing of protein kinase-related antibodies and blocking peptides. Includes application and species-reactivity information.
Protein Kinases: Enzymes and Assay Kits (CB0566) - The industry's most comprehensive listing of purified kinase enzymes, including CaM kinases, casein kinases, MAP kinases, MEK, PKA, PKC (9 isoforms), SAPK, and Tau.
Protein Modification Tools (CB0539) - THIOLYTE® Reagents that react with thiol groups in protein to produce fluorescent products. Also, included is a complete list of our biotin/avidin reagents and kits and our crosslinkers. Structures, product comparisons, and references are provided.
Protein Phosphatases (CB0524) - Our complete line of protein phosphatases and PP inhibitors.
Protein Tyrosine Kinase Inhibitors (CB0611) - Our complete line of PTK inhibitors, including the most comprehensive line of tyrphostins on the market. Table with structures and valuable IC50/Ki values and selected references.