Protein kinases catalyze the transfer of a phosphate group from ATP to serine, threonine, or tyrosine side chains on their target proteins. Due to their involvement in diseases such as cancer and inflammation, they are the subjects of intense drug discovery research. Traditionally, this research has focused on the development of small molecule inhibitors targeting the catalytic site of the kinase. More recently, however, inhibitors targeting other, allosteric, sites have been sought after. Allosteric inhibitors may target conformational states only present when the kinase binds to its endogenous, protein substrate. For this reason, full length substrates, instead of peptides, are suggested for kinase screens¹. Now, you can obtain more biologically relevant results using Calbiochem® Full Length Protein Kinase Substrates. Use the table below to determine which substrate will meet your needs. Obtain consistent kinase screening results by using Calbiochem® Protein Kinase Assay Kits, Inhibitors, and Enzymes.