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Immobilized Inhibitors
 | | | | Capture your kinases, proteases, and other proteins with our line of Immobilized Inhibitors. These inhibitors are covalently bound to acrylic beads and serve as functional ligands that selectively interact with the active site of enzymes in cell lysates or tissue extracts. These affinity precipitation beads are useful in capturing up-regulated target proteins, which interact with immobilized inhibitor ligands. Due to their selective nature, these immobilized inhibitors are also useful tools in affinity purification of target proteins. | | | | | | E-64, Immobilized, (Cat. No. 324891) |  | Western blot analysis of E-64 affinity resin binding to cathepsin B:
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| An immobilized form of the cysteine protease inhibitor E-64 (Cat. No. 324890) covalently attached to hydrophilic acrylic beads via a 4-carbon spacer. Useful to affinity-precipitate cathepsins and other functionally related proteins from cell lysates or tissue extracts. Binding capacity: > 2 mg purified cathepsin B per gram of dry beads
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| | | | | | | Ro 31-7549, Immobilized, (Cat. No. 557509) |  | Western blot analysis, using anti-PKC-a, of Ro 31-7549 affinity resin binding to PKC:
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| An immobilized form of the protein kinase C inhibitor Ro 31-7549 (Cat. No. 557508) that is covalently attached to hydrophilic acrylic beads via an 8-carbon spacer. Useful to affinity-precipitate protein kinase C and other functionally related proteins from cell or tissue extracts. Binding capacity : > 3 mg purified PKCa per gram of dry beads.
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| | | | | | | SB 202190, Immobilized, (Cat. No. 559403) |  | Western blot analysis of SB202190 affinity resin binding to p38 MAP Kinase:
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| An immobilized form of the p38 MAP kinase inhibitor (Cat. No. 559388) that is covalently attached to hydrophilic acrylic beads via a 3-carbon spacer. Useful to affinity-precipitate p38 MAP kinase and other functionally related proteins from cell or tissue extracts. Binding capacity: > 1 mg p38 MAP kinase per gram of dry beads (as determined for recombinant GST-p38).
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