Product Spotlight: Newly Improved Cell-Permeable Proteasome Inhibitor

a-Methylomuralide
Cat. No.: 426104

A cell-permeable a-methyl analog of clasto-Lactacystin b-Lactone (Omuralide, Cat. No. 426102) that displays improved hydrolytic stability. Reported to be a potent, selective, irreversible inhibitor of proteasome function (k_inact chymotrypsin-like peptidase activity of purified 20S proteasome from bovine brain = 2300 M^-1s^-1 for a-Methylomuralide vs 3060 M^-1s^-1 for Omuralide).
Purity: >95% by TLC.