Methyltransferase Reagents
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 Transcriptional repression by hypermethylation of promoter regions is a primary means for the inactivation of gene function. Hypermethylation at promoter sites of regulatory genes is often deleterious. For example, p16 is one of the most important cell cycle regulatory proteins. The loss of p16 function leads to cancer progression by allowing unregulated cell proliferation. Hypermethylation-mediated inactivation of the p16 gene has been demonstrated in a wide array of cancers. Approximately 30% to 40% of colon cancer is attributed to hypermethylated p16 alleles. |
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| Anti-5-Methylcytosine Mouse mAb (162 33 D3) (Cat. No. NA81) is: |
| Specific
Affinity purified mouse monoclonal antibody - Detects methylated DNA from a broad range of species. | | Several Applications
| Flow Cytometry | | Frozen Sections | | Immunoblotting | | Immunofluorescence | | Paraffin Sections |
| | Reliable
Generates reproducible results.
Clone 162 33 D3 has been used in over 50 publications. |
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| Chromosome methylation patterns of mouse embryos at the one-cell stage. Methylated sites were revealed by indirect immunofluorescence labeling with Anti-5-methylcytosine (Cat. No. NA81)
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| Other Products |
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| Antibodies |
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| Anti-DNA Methyltransferase 3a (86-100) Rabbit pAb |
317282 |
| Anti-DNA Methyltransferase 3b (1-14) Rabbit pAb |
317284 |
| Anti-ICMT (170-279) Rabbit pAb |
CA1031 |
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| Inhibitors |
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| 5-Aza-2′-Deoxycytidine |
189825 |
| DNA Methyltransferase Inhibitor |
260920 |
| Protein Arginine N-Methyltransferase Inhibitor, AMI-1 |
539209 |
| InSolution™ Sinefungin |
567051 |
| Zebularine |
691400 |
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Related Links |
| DNA Methyltransferase Inhibitors |
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