APAF-1 (apoptotic peptidase activating factor) gene encodes a cytoplasmic protein that initiates apoptosis. Modulation of apoptosome function in cancer has been observed in metastatic melanomas in which APAF-1 protein was lost due to methylation-induced transcriptional silencing.
NEW! Anti-APAF-1 Rabbit pAb Cat. No. AP1052 Detection of human APAF-1 (~130 kDa) by immunoblotting.
PARC (p53-associated parkin-like cytoplasmic protein), is a ubiquitin ligase that acts as a cytoplasmic anchor protein for p53. PARC directly interacts with p53 and forms a 1 MDa complex in the cytoplasm of unstressed cells. Inactivation of PARC induces nuclear localization of p53 and induces p53-dependent apoptosis.
NEW! Anti-PARC (1-763) Rabbit pAb Cat. No. DR1040 Detection of human PARC (270 kDa) by immunoblotting.
TIP60 (tat interacting protein) is a 60 kDa protein that is a member of the MYST family, which is a distinct class of histone acetyl-transferases (HAT). TIP60 acts as a transcription coactivator of p53 that enhances the activation of p21 and puma, leading to cell growth arrest and apoptosis.
NEW! Anti-TIP60 Rabbit pAb Cat. No. DR1041 Detection of human TIP60 (~60 kDa) by immunoblotting and immunoprecipitation.
Please also visit our Apoptosis Interactive Pathway:
