EMD - Calbiochem - Inhibitors: Phosphorylation/Dephosphorylation

		Technical Resources

		Technical Information

		Calbiochem Information

		Inhibitor Resource

		Phosphorylation Dephosphorylation

		AKT
		AMPK
		Aurora Kinase
		Cam Kinase
		Casein Kinase
		Checkpoint Kinase
		Cyclin-dependent Kinase
		DNA-Dependent Protein Kinase
		Glycogen Synthase Kinase
		c-Jun N-Terminal Kinase
		IP3 Kinase & TGF-b Receptor I Kinase
		MAP Kinase
		MLCK
		PI 3 Kinase
		Protein Kinase A
		Protein Kinase C
		Protein Kinase G
		Protein Phosphatase
		Protein Tyrosine Kinase
		Raf Kinase
		Rho Kinase
		Sphingosine Kinase

Phosphorylation/Dephosphorylation: Casein Kinase (CK) Inhibitors

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Casein kinases I and II (CKI and CKII) are highly conserved, ubiquitous serine/threonine protein kinases that play a significant role in neoplasia and cell survival. CKI can be found in the nucleus and the cytosol and is bound to the cytoskeleton and membranes. The CKI family consists of several isoforms (CKIa, b, g1, g2, g3, d, and e) encoded by seven distinct genes. It plays a significant role in the regulation of circadian rhythm, intracellular trafficking and also acts as a regulator of Wnt signaling, nuclear import, and the progression of Alzheimer’s disease. CKII has traditionally been classified as a messenger-independent protein serine/threonine kinase and consists of two catalytic and two regulatory subunits. It plays an important role in the progression of the cell cycle and in maintenance of cell viability. It is highly conserved and is known to phosphorylate about 300 different proteins. CKII activity is required at transition points of the cell cycle. Excessive activity of CKII has been linked to oncogenic transformation and the development of primary and metastatic tumors.

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Inhibitors: Casein Kinase (CK)

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