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Recombinant Active Phosphodiesterases
 | | | | cAMP and cGMP, two important second messenger molecules, are hydrolyzed by Phosphodiesterases (PDEs) in the cell, leading to cessation of cAMP- and cGMP-dependent effects. PDEs comprise a large group of enzymes organized into 11 distinct families based on biochemical and molecular properties. Many of these isozymes are differentially expressed and regulated in different cells and exhibit distinct selectivity for cAMP and cGMP. However, these isozymes exhibit significant sequence homology in their catalytic domains. Due to their involvement in inflammation, asthma, and cardiovascular complication, PDEs are considered to be attractive targets for pharmacological intervention. A number of PDE inhibitors have been developed that target specific isoenzymes, thereby increasing tissue selectivity and minimizing side effects. | | | NEW! Phosphodiesterase 1A3, Active, Human, Recombinant, S. frugiperda ( Cat. No. 524740 )
Full-length, human recombinant phosphodiesterdase 1A3 (PDE1A3) expressed in Spodoptera frugiperda insect cells using a baculovirus expression system. Supplied as a partially purified preparation of catalytically active enzyme.
Image caption: Phosphodiesterase 1A3 was treated with increasing concentrations of the inhibitor, 8Me-IBMX (Cat. No. 454202) and the activity determined. The IC50 for this inhibition is 6.04 mM. |  |
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| | | | | | Recombinant Phosphodiesterases |
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| Phosphodiesterase 11A1, Active, Human, Recombinant, S. frugiperda |
≥0.5 units/µl |
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524735 |
| Phosphodiesterase 1A3, Human, Recombinant, S. frugiperda |
≥0.5 units/µl |
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524740 |
| Phosphodiesterase 3B, Human, Recombinant, S. frugiperda |
≥0.5 units/µl |
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524734 |
| Phosphodiesterase 3A1, Catalytic Domain, Human, Recombinant, S. frugiperda |
≥0.5 units/µl |
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534736 |
| Phosphodiesterase 4A4, Human, Recombinant, S. frugiperda |
≥0.5 units/µl |
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524731 |
| Phosphodiesterase 4B2, Human, Recombinant, S. frugiperda |
≥ 0.5 units/µl |
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524736 |
| Phosphodiesterase 4B2, Catalytic Domain, His•Tag®, Human, Recombinant, S. frugiperda |
≥0.5 units/µl |
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524732 |
| Phosphodiesterase 4C2, Human, Recombinant, S. frugiperda |
≥ 0.5 units/µl |
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524737 |
| Phosphodiesterase 4D3, Human, Recombinant, S. frugiperda |
≥0.5 units/µl |
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524733 |
| Phosphodiesterase 5, Catalytic Domain, Human, Recombinant, S. frugiperda |
≥ 0.5 units/µl |
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524738 |
| Phosphodiesterase, Type II, Calf Spleen |
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≥7 units/mg protein |
524711 |
| Phosphodiesterase, Type V, cGMP-Specific, Bovine, Recombinant, Spodoptera frugiperda |
≥50,000 units/ml |
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524715 |
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| | | | Related Products: Selected Phosphodiesterase Inhibitors | | Product Name | Cat. No. | Calmidazolium Chloride
A selective inhibitor of PDE I (IC50= 10 nM) | | Cilostamide
A selective inhibitor of PDE III (IC50 = 70 nM) | | 3-Isobutyl-1-methylxanthine
A non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC50= 2-50 mM) | | 4-{[3', 4'- (Methylene-dioxy)benzyl]amino}-6-methoxyquinazoline
A potent and specific inhibitor of PDE V (IC50= 230 nM) | | Rolipram
A selective competitive inhibitor of PDE IV (IC50= 800 nM) | |
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