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Product Spotlight: New Antibodies for Signal Transduction Research

Antibodies for Breast Cancer Markers

 

Anti-BRST-1, Human (Mouse)
Cat. No. CA1000
Size: 200 ml
BCA-225 protein secreted from the T47D human breast carcinoma cell line was used as an immunogen. Detects the BCA-225 glycoprotein which is secreted by the T47D human carcinoma cell line. A useful marker for breast and cervical carcinomas. Shows strong intracytoplasmic staining in primary and metastatic breast carcinoma tissue and in cervical carcinomas.


Cytoplasmic staining in breast carcinoma tissue
Anti-BRST-2, Human (Mouse)
Cat. No. CA1001
Size: 200 ml
Gross cystic disease fluid protein-15 was used as an immunogen. Detects Gross Cystic Disease Fluid Protein 15 (GCDFP-15), expressed in the metaplastic epithelium of breast tissue. GCDFP-15 is a useful marker for the detection of breast carcinoma and the identification of metastasis of breast origin.

Staining seen in lobular breast carcinoma

Anti-BRST-3, Human (Mouse)
Cat. No. CA1002
Size: 200 ml
A membrane-enriched fraction of a breast carcinoma metastatic to the liver was used as an immunogen. Detects TAG-72, a 220-440 kDa tumor-associated oncofetal protein complex expressed in a wide variety of adenocarcinomas including invasive ductal breast carcinoma, colon, pancreatic, and gastric cancers. 

 
BRST-3 staining seen in breast carcinoma

 

Antibodies for Pleckstrin

 

Anti-Pleckstrin, C-Terminal, Human (Rabbit)
Cat. No.: ST1003
Size: 50 ml
A synthetic peptide corresponding to amino acids 337-350 of pleckstrin was used as an immunogen. Detects the ~47 kDa pleckstrin, the major substrate of protein kinase C in platelets. When phosphorylated, pleckstrin has been shown to bind to inositol polyphosphate 5-phosphatase I.

 
Anti-Pleckstrin, Human (Rabbit)
Cat. No.: ST1004
Size: 50 ml
Purifed human pleckstrin was used as an immunogen. Detects only pleckstrin and pleckstrin fragments.