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Product Spotlight: Ubiquitination - New Targeted Antibodies
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| Cat. No. | Name | Description | Species Reactivity | Applications | References | | PC745 | Anti-CAND1 Rabbit pAb | CAND1 regulates the assembly of productive SCF ubiquitin ligases. The SCF ubiquitin E3 ligase complex controls the levels of several proteins involved in cell cycle control and signal transduction. | Human, Mouse, Rat | IB, IF, IP | Zheng, J., et al. 2002. Mol. Cell 10, 1519. | | PC711 | Anti-CHIP Rabbit pAb | CHIP is a U-box dependent E3 ubiquitin ligase. CHIP is a co-chaperone protein which interacts with Hsc70 and Hsp90 regulating protein triage decisions between folding and degradation. CHIP has been reported to be involved in the degradation of c-ErbB2/c-Neu, the glucocorticoid receptor, and the cystic fibrosis transmembrane-conductance regulator. | Drosophilia, Hamster, Human, Monkey, Rat | IB, IF ,IP | Xu, W., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 12847; Connell, P., et al. 2001. Nat. Cell Biol. 3, 93; Jiang. J., et al. 2001. J. Biol. Chem. 276, 42938; Ballinger, C.A., et al. 1999. Mol. Cell. Biol. 19, 4535. | | 231005 | Anti-CIN85, Internal Rabbit pAb | CIN85 is a protein involved in the degradation of several tyrosine kinase receptors including epidermal growth factor (EGF), hepatocyte growth factor (HGF), platelet derived growth factor (PDGF), and c-Kit receptors. Will also detect the mono-ubiquinated form of CIN85. | Human, Mouse, Porcine, Rat | IB, IF, IP | Haglund, K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 12191; Petrelli , A., et al. 2002. Nature 416, 187; Souberyan, P., et al. 2002. Nature 416, 183; Szymkiewicz, I., et al. 2002. J. Biol. Chem., in press. | | 231006 | Anti-CIN85, C-Terminal Rabbit pAb | CIN85 is a protein involved in the degradation of several tyrosine kinase receptors including epidermal growth factor (EGF), hepatocyte growth factor (HGF), platelet derived growth factor (PDGF), and c-Kit receptors. Will also detect the mono-ubiquinated form of CIN85. | Human, Mouse, Porcine, Rat | ELISA, IB, IF, IP | Haglund, K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 12191; Petrelli, A., et al. 2002. Nature 416, 187; Souberyan, P., et al. 2002. Nature 416, 183; Szymkiewicz, I., et al. 2002. J. Biol. Chem., in press. |
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