Protein : MAPK14 (p38alpha)


Connectivity	2362
Notes	The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Hugo ID	6876
Name	MAPK14 (p38alpha)
Description	mitogen activated protein kinase 14
URN	urn:agi-llid:1432


Cell Localization	Cytoplasm
	Nucleus


GO Biological Process	angiogenesis
	protein amino acid phosphorylation
	protein kinase cascade
	DNA damage checkpoint
	antimicrobial humoral response (sensu Vertebrata)
	cell motility
	cell surface receptor linked signal transduction
	chemotaxis
	response to stress


EC Number	2.7.1.37


State Description	Transcript Variant: This variant (1) encodes the longest isoform (1).
	Transcript Variant: This variant (2) contains a different segment within the coding region when compared to variant 1. The translation frame remains the same, and the resulting isoform 2 has an internal segment different from that of isoform 1.
	Transcript Variant: This variant (3) contains a different internal segment within the coding region, and a different 3' coding region as well as a different 3' UTR, when compared to variant 1. It thus encodes an isoform that has a different internal se...
	Transcript Variant: This variant (4) contains a different internal segment when compared to variant 1. It thus encodes an isoform that has a different and shorter internal segment, as compared to isoform 1.


MGI ID	1346865


Swiss-Prot Accession	Q16539


OMIM ID	OMIM:600289


Alias	Mapk14
	RK
	Hog
	p38
	CSBP
	Exip
	Mxi2
	CSPB1
	Csbp1
	Csbp2
	Prkm14
	Prkm15
	Sapk2A
	p38Hog
	mitogen activated protein kinase 14
	MAP kinase 2
	p38alpha Exip
	p38 MAP kinase
	MAP kinase Mxi2
	reactive kinase
	Csaids binding protein
	MAX-interacting protein 2
	stress-activated protein kinase 2A
	p38 mitogen activated protein kinase
	cytokine-supressive anti-inflammatory drug binding protein
	cytokine suppressive anti-inflammatory drug binding protein
	p38alpha
	Crk1
	p38MAPK
	cytokine suppressive anti-inflammatory drug binding protein 1
	p38-alpha
	mitogen-activated protein kinase 14
	CSAID binding protein
	CSBP I
	CSPB I
	cytokine suppressive anti-inflammatory drug binding protein I
	MAP kinase p38
	MAPK p38
	MAX-interacting protein II
	MAX-interactive protein 2
	MAX-interactive protein II
	Mitogen-activated protein kinase p38
	p38 kinase
	p38 MAPK
	p38alpha mitogen-activated protein kinase
	P-38


RGD ID	70496


Pathway	CREB signaling
	p38 Signaling
	imported DNA Repair proteins
	PL AKT signaling
	MAPK Family Pathways