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PKC Interactive Pathway: ERK2
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| Anti-MAP Kinase ERK1/ERK2 (333-367) Rabbit pAb |
IB, IP, PS |
chicken, clam, Drosophila, frog, human, mouse, rat, sea star, sheep |
442675 |
| PhosphoDetect™ Anti-MAP Kinase ERK1/ERK2 (pThr202/Tyr204) Mouse mAb (12D4) |
ELISA, IB, IP |
human, mouse, rat |
442706 |
| PhosphoDetect™ Anti-MAP Kinase ERK1/ERK2 (pThr202/Tyr204) Rabbit pAb |
DB, IB |
human, rat |
442685 |
| Anti-MAP Kinase ERK1/ERK2 Rabbit pAb |
FC, IB, PS |
hamster, human, mouse, rat, zebrafish |
442704 |
| Anti-MAP Kinase ERK2, N-Terminal (6-17) Rabbit pAb |
IB |
human, mouse, rat, Xenopus, yeast |
442680 |
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| | | | Inhibitors | |
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| ERK 1/2 ELISA Kit |
96-well plate |
96 Tests |
< 16 pg/ml |
31.2-2000 pg/ml |
4 h |
Cells |
CBA032 |
| PhosphoDetect™ ERK1/2 (pThr185/pTyr187) ELISA Kit |
96-well plate |
96 Tests |
≤0.8 units/ml |
1.6-100 units/ml |
4 h |
Cell lysates |
CBA006 |
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| | | | Proteins/Enzymes |
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| MAP Kinase 2, His•Tag®, Human, Recombinant, E. coli |
454854 |
| MAP Kinase 2, Activated, Rat, Recombinant, E. coli |
454855 |
| MAP Kinase 2, Mouse, Recombinant, E. coli |
454850 |
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| | | | Substrates |
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| Myelin Basic Protein Peptide Substrate |
475920 |
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| | | | Additional Information | | | | | | | | |
| Protein : MAPK1 (ERK2)
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| Connectivity | 5227 |
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| Notes | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. |
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| Hugo ID | 6871 |
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| Name | MAPK1 (ERK2) |
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| Description | mitogen activated protein kinase 1 |
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| URN | urn:agi-llid:5594 |
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| GO Cellular Component | cytosol |
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| | insoluble fraction |
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| | cytoplasm |
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| | nucleus |
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| Cell Localization | Cytoplasm |
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| | Nucleus |
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| GO Biological Process | cell cycle |
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| | intracellular signaling cascade |
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| | nuclear translocation of MAPK |
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| | positive regulation of transcription |
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| | protein amino acid phosphorylation |
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| | protein kinase cascade |
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| | signal transduction |
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| | organogenesis |
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| | phosphorylation |
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| | chemotaxis |
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| | induction of apoptosis |
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| | response to stress |
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| | synaptic transmission |
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| EC Number | 2.7.1.- |
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| | 2.7.1.37 |
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| State Description | Transcript Variant: This variant (1) contains a different 3' UTR region, however, encodes the same protein as compared to variant 2. |
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| | Transcript Variant: This variant (2) contains a different 3' UTR region, however, encodes the same protein as compared to variant 1. |
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| Alias | Mapk1 |
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| | Erk2 |
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| | Rsk-1 |
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| | mitogen activated protein kinase 1 |
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| | extracellular-signal-regulated kinase 1 |
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| | ERK |
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| | MAPK2 |
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| | PRKM2 |
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| | Prkm1 |
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| | p41mapk |
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| | p42mapk |
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| | 9030612K14Rik |
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| | p40 |
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| | p41 |
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| | ERT1 |
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| | MK01 |
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| | p40-ARC |
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| | p41-ARC |
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| | mitogen-activated protein kinase 1 |
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| | protein tyrosine kinase ERK2 |
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| | mitogen-activated protein kinase 2 |
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| | extracellular signal-regulated kinase 2 |
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| | MK01_HUMAN |
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| | MAP kinase 1 |
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| | C78273 |
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| | ERT I |
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| | Extracellular regulated kinase 2 |
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| | Extracellular regulated kinase II |
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| | Extracellular signal- regulated kinase 2 |
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| | Extracellular signal- regulated kinase II |
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| | MAP kinase 1 |
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| | MAP kinase I |
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| | MAP kinase 2 |
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| | MAP kinase II |
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| | MAPK I |
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| | mitogen activated protein kinase I |
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| | Mitogen-activated protein kinase II |
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| | p42 mitogen activated protein kinase 1 |
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| | PRKM I |
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| | protein kinase, mitogen-activated 1 |
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| | protein kinase, mitogen-activated I |
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| Organism | Rattus norvegicus |
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| | Mus musculus |
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| | Human |
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| Pathway | IL-2 signaling |
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| | IL-3 signaling |
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| | IL-6 signaling |
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| | Inhibition of Apoptosis |
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| | Insulin pathway |
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| | Insulin Receptor Signaling |
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| | Integrin Signaling |
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| | Jak-Stat Pathway from IL6 Receptor |
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| | MAPK signaling |
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| | Toll-Like Receptor pathway |
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| | CREB signaling |
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| | EGF signaling |
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| | Erk-PI3K in Collagen Binding |
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| | G-protein Coupled Receptor signaling |
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| | Antiapoptotic Pathways From IGF-1R |
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| | MAPK-ERK in Growth and Differentiation |
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| | Mitochondrial control of Apoptosis |
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| | NGF signaling |
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| | PDGF signaling |
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| | Apoptosis |
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| | AKT signaling |
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| | PL AKT signaling |
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| | MyCopy of 'ATM signaling' |
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| | MAPK Family Pathways |
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| | NFkB1 expanded |
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| | IKB-NFkB |
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| | Copy of 'Insulin pathway' |
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| Group | Kinases |
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| | nucleotide binding |
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