 |
|
|
|
|
PKC Interactive Pathway: RAF1
 | | |  Antibodies |
|
|
|
|
|
| Anti-A-Raf Protein Kinase, C-Terminal (584-597) Rabbit pAb |
ELISA, IB, IP |
human, mouse, rat |
553001 |
| PhosphoDetect™ Anti-c-Raf (pSer621) Mouse mAb (6B4) |
ELISA, IB |
human |
553010 |
| PhosphoDetect™ Anti-c-Raf (pTyr340, Tyr341) Rabbit pAb |
IB, IC |
human, mouse, rat |
553009 |
| PhosphoDetect™ Anti-Raf (pSer259) Rabbit pAb |
IB, IP, PS |
human, mouse, rat |
ST1076 |
| Anti-Raf1 (Ab-2) (380-403) Rabbit pAb |
IB |
human, mouse |
PC91 |
|
| | | | Inhibitors |
|
|
|
| Raf Kinase Inhibitor III |
553013 |
| Raf Kinase Inhibitor IV |
553014 |
| Raf1 Kinase Inhibitor I |
553008 |
| InSolution™ Raf1 Kinase Inhibitor I |
553003 |
| ZM 336372 |
692000 |
|
| | | | Additional Information | | | | | | | | |
| Protein : RAF1
| | |
|---|
| Connectivity | 1556 |
|---|
| Notes | Raf-1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. [Contributed text] |
|---|
| Hugo ID | 9829 |
|---|
| Name | RAF1 |
|---|
| Description | murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV) |
|---|
| URN | urn:agi-llid:5894 |
|---|
| | |
|---|
| GO Cellular Component | cytosol |
|---|
| | insoluble fraction |
|---|
| | intracellular |
|---|
| | plasma membrane |
|---|
| | mitochondrial outer membrane |
|---|
| | |
|---|
| Cell Localization | Cytoplasm |
|---|
| | Mitochondria |
|---|
| | |
|---|
| GO Biological Process | cell growth and/or maintenance |
|---|
| | heart development |
|---|
| | intracellular signaling cascade |
|---|
| | protein amino acid phosphorylation |
|---|
| | protein kinase cascade |
|---|
| | regulation of cell cycle |
|---|
| | signal transduction |
|---|
| | apoptosis |
|---|
| | cell proliferation |
|---|
| | |
|---|
| Alias | Raf1 |
|---|
| | murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV) |
|---|
| | v-raf-1 murine leukemia viral oncogene homolog 1 |
|---|
| | Craf1 |
|---|
| | Raf-1 |
|---|
| | c-Raf |
|---|
| | v-Raf |
|---|
| | v-raf-1 leukemia viral oncogene 1 |
|---|
| | sarcoma 3611 oncogene |
|---|
| | Craf1 transforming gene |
|---|
| | murine sarcoma 3611 oncogene 1 |
|---|
| | protein kinase raf 1 |
|---|
| | 6430402F14Rik |
|---|
| | D830050J10Rik |
|---|
| | Raf |
|---|
| | MIL |
|---|
| | Oncogene RAF1 |
|---|
| | raf proto-oncogene serine/threonine protein kinase |
|---|
| | RAF1_HUMAN |
|---|
| | protein kinase raf-1 |
|---|
| | AA990557 |
|---|
| | cRaf |
|---|
| | c-Raf-1 |
|---|
| | KRAF |
|---|
| | murine sarcoma 3611 oncogene I |
|---|
| | Oncogene RAF I |
|---|
| | protein kinase raf I |
|---|
| | Raf I |
|---|
| | Raf kinase |
|---|
| | raf oncogene |
|---|
| | RAS-GTP binding protein kinase |
|---|
| | v-raf-1 leukemia viral oncogene I |
|---|
| | v-raf-1 murine leukemia viral oncogene homolog I |
|---|
| | KRAF_HUMAN |
|---|
| | (RAF1) |
|---|
| | (RAF) |
|---|
| | |
|---|
| Organism | Rattus norvegicus |
|---|
| | Mus musculus |
|---|
| | Human |
|---|
| | |
|---|
| Pathway | IL-1 and IL-6 signaling |
|---|
| | IL-2 signaling |
|---|
| | IL-3 signaling |
|---|
| | IL-6 signaling |
|---|
| | Inhibition of Apoptosis |
|---|
| | Insulin pathway |
|---|
| | Insulin Receptor Signaling |
|---|
| | Integrin Signaling |
|---|
| | Jak-Stat Pathway from IL6 Receptor |
|---|
| | EGF signaling |
|---|
| | Erythropoietin signaling |
|---|
| | Erk-PI3K in Collagen Binding |
|---|
| | G-protein Coupled Receptor signaling |
|---|
| | Antiapoptotic Pathways From IGF-1R |
|---|
| | MAPK-ERK in Growth and Differentiation |
|---|
| | NGF signaling |
|---|
| | PDGF signaling |
|---|
| | MAPK Family Pathways |
|---|
| | Copy of 'Insulin pathway' |
|---|
| | |
|---|
| Group | Kinases |
|---|
| | nucleotide binding |
|---|
| | protein binding |
|---|
| | lipid binding |
|---|
|
|
 |
|
|
