Ubiquitin-Proteasome Interactive Pathway: UbqE3

UbqE3 Antibodies Product Application Species Reactivity Cat. No. Anti-E6-AP Rabbit pAb IB, IP human PC543 Anti-UbcH5 Rabbit pAb IB human ST1155 Anti-UbcH6 Rabbit pAb IB, PS human ST1157 Anti-UbcH6e Rabbit pAb IB, PS human ST1156

UbqE3 Enzymes Product Cat. No. Fraction II, Rabbit Reticulocytes 344260 Ubiquitin Conjugating Enzyme Set 662116

Additional Information

Protein : UBE3B Connectivity 0 Notes The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E3 ubiquitin-conjugating enzyme family. The encoded protein may interact with other proteins and play a role in stress response. Multiple transcript variants encoding two distinct isoforms have been identified for this gene. Hugo ID 13478 Name UBE3B Description ubiquitin protein ligase E3B URN urn:agi-llid:89910 GO Cellular Component intracellular Cell Localization Cytoplasm GO Biological Process protein modification ubiquitin cycle State isoform A isoform B State Description Transcript Variant: This variant (1) represents the longer transcript of two (variants 1 and 3) that encode the longer isoform (a). Variant 1 is also known as UBE2B_v1. Transcript Variant: This variant (2) includes an alternate in-frame exon in the coding region, which results in an early stop codon, compared to variant 1. The encoded isoform (b) is predicted to be nonfunctional because it lacks the HECT domain, as co... Transcript Variant: This variant (3) represents the shorter transcript of two (variants 1 and 3) that encode the longer isoform (a). Variant 3 uses a different splice in the 5' UTR, compared to variant 1. MGI ID 1891295 OMIM ID OMIM:608047 Alias Ube3b ubiquitin protein ligase E3B DKFZp586K2123 DKFZp686A1051 AI449831 similar to ubiquitin-protein isopeptide ligase (E3) Organism Mus musculus Human LocusLink ID 100657 100816 117146 89910 Pathway Ubiquitin Unigene ID Mm.28792 Hs.305834

 

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