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Alzheimer's Disease Related Products - GSK-3
 | | | | Glycogen Synthase Kinase-3b (GSK-3b; tau protein kinase I), a highly conserved, ubiquitously expressed serine/threonine protein kinase is involved in the signal transduction cascades of multiple cellular processes. It is negatively regulated by protein kinase B/Akt and by the Wnt signaling pathway. Higher levels of GSK-3b have been shown in pre-tangle and in phosphorylated tau bearing neurons. Overexpression of GSK-3b is a characteristic feature of Alzheimer’s disease. GSK-3b accounts for most major phosphorylation sites of fetal and paired helical filament-tau. b-Amyloid peptides are shown to activate GSK-3b, suggesting that activation of GSK-3b is a key mechanism in the pathogenesis of Alzheimer’s disease. The development of GSK-3 inhibitors holds considerable promise for reducing tau phosphorylation and the debilitating effects of Alzheimer’s disease. | | | | GSK-3 Antibodies |
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| Anti-GSK-3a/b Mouse mAb (1H8) |
ELISA, IB |
bovine, canine, hamster, human, mouse, ovine, porcine, rabbit, rat |
368662 |
| Anti-GSK-3b, C-Terminal (334-348) Rabbit pAb |
ELISA, IB, IP |
human, mouse, rat |
361528 |
| PhosphoDetect™ Anti-GSK-3a/b (pTyr279/216) Rabbit pAb |
DB, ELISA, IB, IC |
human, mouse, rat |
ST1013 |
| PhosphoDetect™ Anti-GSK-3b (pSer9) (Ab-1) Rabbit pAb Rabbit pAb |
DB, ELISA, IB |
human, rat, Xenopus |
PC242 |
| PhosphoDetect™ Anti-GSK-3b, (pSer9) Rabbit pAb |
IB |
human, rat |
PS1018 |
| PhosphoDetect™ Anti-GSK3b (pSer9) Mouse mAb (2D3) |
ELISA, IB |
human, mouse |
361527 |
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| | | | GSK-3 Inhibitors | |
| | | | GSK-3 Enzymes |
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| GSK-3a, GST-Fusion, Human, Recombinant, S. frugiperda |
361523 |
| GSK-3b, His•Tag®, Human, Recombinant, E. coli |
361524 |
| GSK-3b, Rabbit Skeletal Muscle, Recombinant, E. coli |
361526 |
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| | | | GSK-3 Substrates | |
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