Apoptosis Pathway: IkB

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Antibodies

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Antisense Oligonucleotides

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Inhibitors

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Kit

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Protein : IKBA (NFKBIA)


Connectivity	1026
Notes	NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]
Hugo ID	7797
Name	IKBA (NFKBIA)
Description	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
URN	urn:agi-llid:4792


Cell Localization	Nucleus
	Cytoplasm


GO Biological Process	protein-nucleus import, translocation
	regulation of cell proliferation
	apoptosis
	cytoplasmic sequestering of NF-kappaB
	response to pathogenic bacteria


MGI ID	104741


Swiss-Prot Accession	P25963


OMIM ID	OMIM:164008


Alias	Nfkbia
	RL/IF-1
	nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha
	Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells alpha
	Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells, alpha
	Nfkbi
	I(Kappa)B(alpha)
	nuclear factor of kappa light polyp gene enhancer in B-cell 1
	I-kappaB-alpha
	P-I-kappaB-alpha
	AI462015
	expressed sequence AI462015
	MAD-3
	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
	Nuclear factor of kappa light chain gene enhancer in B-cells
	IKBA_HUMAN
	major histocompatibility complex enhance-binding protein MAD3
	IkappaBalpha
	IKBA
	IkBalpha
	Inhibitor of 3000097
	Major histocompatibility complex enhancer- binding protein MAD3
	NF-kappaB inhibitor alpha
	nuclear factor of kappa light polyp gene enhancer in B-cell I
	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibito
	RL/IF I


RGD ID	3171


Group	protein binding

Protein : IKBB (NFKBIB)


Connectivity	63
Notes	NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]
Hugo ID	7798
Name	IKBB (NFKBIB)
Description	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
URN	urn:agi-llid:4793


GO Cellular Component	nucleus


Cell Localization	Cytoplasm
	Nucleus


GO Biological Process	signal transduction
	transcription


State	isoform B
	isoform A


MGI ID	104752


Swiss-Prot Accession	Q15653


OMIM ID	OMIM:604495


Alias	Nfkbib
	I-kappa-B-beta
	IkB
	IkBb
	nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta
	I(Kappa)B(beta)
	IKB-beta
	MGC36057
	TRIP9
	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
	I-kappaB-beta
	IkappaBbeta
	IKB-B
	IkBbeta
	NF-kappaB inhibitor beta
	NF-kappa-BIB
	Thyroid receptor interacting protein 9
	Thyroid receptor interactive protein 9
	Thyroid receptor interactive protein IX
	TR- interacting protein 9
	TR- interactive protein 9
	TR- interactive protein IX


RGD ID	621887