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Apoptosis Pathway: RelA/p65
 | | |  Antibodies
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| Anti-NF-kB (p65) Mouse mAb (2A12A7) |
ELISA, GS, IB |
human |
ST1047 |
| Anti-NF-kB (p65, RelA) (Ab-1) Rabbit pAb |
GS, IB, IP |
human, mouse |
PC137 |
| Anti-NF-kB (p65, RelA) (Ab-2) Rabbit pAb |
ELISA, GS, IB, IP |
human |
PC138 |
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| | | Protein
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| NoShift™ NF-kB (p65) Reagents |
71518 |
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| | | | Additional Information | | | | | | | | |
| Protein : RelA (p65)
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| Connectivity | 422 |
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| Notes | NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM] |
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| Hugo ID | 9955 |
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| Name | RelA (p65) |
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| Description | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) |
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| URN | urn:agi-llid:5970 |
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| GO Cellular Component | cytoplasm |
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| | nucleus |
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| | transcription factor complex |
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| Cell Localization | Nucleus |
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| GO Biological Process | cell growth and/or maintenance |
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| | defense response |
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| | organogenesis |
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| | positive regulation of interleukin-12 biosynthesis |
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| | positive regulation of transcription, DNA-dependent |
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| | regulation of cell cycle |
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| | regulation of transcription, DNA-dependent |
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| | anti-apoptosis |
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| | positive regulation of I-kappaB kinase/NF-kappaB cascade |
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| | response to toxin |
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| | transcription from Pol II promoter |
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| Alias | Rela |
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| | v-rel reticuloendotheliosis viral oncogene homolog A (avian) |
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| | p65 |
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| | p65 NFkB |
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| | p65 NF-kappa B |
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| | avian reticuloendotheliosis viral (v-rel) oncogene homolog A |
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| | TF65_MOUSE |
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| | nuclear factor kappa-B chain p65 |
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| | NFKB3 |
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| | TF65 |
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| | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) |
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| | v-rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (p65)) |
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| | TF65_HUMAN |
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| | Nuclear factor NF-kappa-B p65 subunit |
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| | LOC309165 |
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| | NF kappa B p65 |
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| | NF kappa B 3 |
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| | NF kappa B III |
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| | nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 ( |
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| | Transcription factor p65 |
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| | v-rel avian reticuloendotheliosis viral oncogene homolog A |
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| | v-rel reticuloendotheliosis viral oncogene homolog A |
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| Organism | Rattus norvegicus |
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| | Mus musculus |
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| | Human |
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| Pathway | NFkB |
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| | NFkB1 expanded |
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| | IKB-NFkB |
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| Group | Transcription factors |
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| | protein binding |
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