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Protein : TRADD
Connectivity
145
Notes
The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.
positive regulation of I-kappaB kinase/NF-kappaB cascade
signal transduction
State
isoform 1
isoform 2
State Description
Transcript Variant: This variant (1) encodes a longer isoform (1).
Transcript Variant: This variant (2) differs in the 5' end when compared to variant 1. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 1. This transcript is supported by multiple ESTs, but the predicted ORF has not yet been e...
