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Diabetes and Obesity: Glycogen Synthase Kinase-3
 | | | | | | | Glycogen synthase kinase-3 (GSK-3), a multifunctional serine/threonine kinase, is a key regulator of numerous signaling pathways. Two isoforms of GSK-3 are reported in mammals: a 51 kDa GSK- 3a and a 47 kDa GSK-3b that exhibit about 98% homology in their kinase domains. Several known GSK-3 substrates participate in a wide spectrum of cellular processes, including glycogen metabolism, transcription, translation, cytoskeletal regulation, intracellular vesicular transport, cell cycle progression, stem cell renewal, and apoptosis. | | | | Antibodies |
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| PhosphoDetect™ Anti-Glycogen Synthase (pSer645/649/653/657) Rabbit pAb |
IB, PS |
human |
PC746 |
| Anti-GSK-3a/b Mouse mAb (1H8) |
ELISA, IB |
bovine, canine, hamster, human, mouse, ovine, porcine, rabbit, rat |
368662 |
| Anti-GSK-3b, C-Terminal (334-348) Rabbit pAb |
ELISA, IB, IP |
human, mouse, rat |
361528 |
| PhosphoDetect™ Anti-GSK-3a/b (pTyr279/216) Rabbit pAb |
DB, ELISA, IB, IC |
human, mouse, rat |
ST1013 |
| PhosphoDetect™ Anti-GSK-3b (pSer9) (Ab-1) Rabbit pAb Rabbit pAb |
DB, ELISA, IB |
human, rat, Xenopus |
PC242 |
| PhosphoDetect™ Anti-GSK-3b, (pSer9) Rabbit pAb |
IB |
human, rat |
PS1018 |
| PhosphoDetect™ Anti-GSK3b (pSer9) Mouse mAb (2D3) |
ELISA, IB |
human, mouse |
361527 |
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| | | | Assay Kits |
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| GSK-3b ELISA Kit |
CBA068 |
| PhosphoDetect™ GSK-3b (pSer9) ELISA Kit |
CBA069 |
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| GSK-3b, His•Tag®, Human, Recombinant, E. coli |
361524 |
| GSK-3b, Rabbit Skeletal Muscle, Recombinant, E. coli |
361526 |
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| | | | | | Related Resources | | GSK-3 Signaling Interactive Pathway | | GSK Inhibitors | | | | | |
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