EMD: Diabetes and Obesity - PI 3K Signaling

		Technical Resources

		Technical Information

		Calbiochem Information

		Diabetes Resource

		Akt/PKB Signaling
		PI 3-K Signaling
		AMPK
		mTOR
		Protein Tyrosine Phosphatases
		GSK-3
		Lipids
		Sphingomyelinase
		HMG-CoA
		PPAR
		Phosphodiesterases
		Glucose Transporters
		Insulin like Growth factors
		IGF Receptor
		Insulin Mimetics
		JAK/STAT
		Tumor Necrosis Factor
		Inhibitors of Mitochondrial Function
		Sirtuins and Leptin
		Orexins, Resistin, Peptides, C-Reactive
		Other products of interest

Diabetes and Obesity: Phosphoinositide 3-Kinases (PI 3-K)

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The PI 3-kinases are ubiquitous, heterodimeric lipid kinases that play a pivotal role in the regulation of many cellular processes, including cell growth, motility, proliferation, and survival. They are dualspecificity enzymes capable of phosphorylating phosphoinositides. The PI 3-kinase family has eight members divided into four major classes that differ in their substrate selectivity and regulation.

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References:
�	Leslie, N.R. 2006. Antioxid. Redox Signal. 8, 1765.
�	Samuels, Y., and Ericson, K. 2006. Curr. Opin. Oncol. 18, 77
�	Bader, A.G., et al. 2005. Nat. Rev. Cancer 5, 921.
�	Fiona, M., et al. 2003. J. Cell Sci. 116, 3037.
�	Scheid, M.P., and Woodgett, J.R. 2003. FEBS Lett. 546, 108.
�	Lawlor M.A., and Alessi, D.R. 2001. J. Cell Sci. 114, 2903.
�	Toker, A., and Newton, A.C. 2000. J. Biol. Chem. 275, 8271.
�	Stein, R.C, and Waterfield, M.D. 2000. Mol. Med. Today 6, 347.
�	Dong, Z., et al. 1999. Anticancer Res. 19, 3743.
�	Prior, I.A., and Clague, M.J. 1999. Mol. Cell Biol. Res. Commun. 1, 162.

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Antibodies

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Assay Kit

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Inhibitors

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Related Resources

Inhibitor Resource

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