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Diabetes and Obesity: Akt/PKB Signaling
 | | | | | | | Akt (protein kinase B), a serine/threonine kinase, is a critical enzyme in several signal transduction pathways involved in cell proliferation, apoptosis, angiogenesis, and diabetes. In mammals three isoforms of Akt have been reported (a, b, g or Akt 1, 2, 3) that exhibit a high degree of homology, but differ slightly in the localization of their regulatory phosphorylation sites. Akt1 plays an important role in growth and anti-apoptosis; Akt2 acts primarily as a regulator of glucose metabolism. Although Akt3 does not contribute significantly to the maintenance of normal metabolism in tissues, it is essential for the attainment of normal organ size, probably influencing both cell size and number via mTOR activation. | | | | | | | Antibodies |
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| Anti-Akt, PH Domain Mouse mAb (SKB1) |
FC, IB, IP |
human, mouse, rat |
ST1088 |
| Anti-Akt1 (Ab-1) (135-145) Rabbit pAb |
IC, NOT IB, NOT PS |
human, mouse |
PC510 |
| Anti-Akt1 (88-100) Rabbit pAb |
ELISA, IB, IP |
human, mouse, rat, Xenopus |
530311 |
| PhosphoDetect™ Anti-Akt1 (pSer473) Mouse mAb (11E6) |
ELISA, IB |
human, mouse |
124003 |
| PhosphoDetect™ Anti-Akt1 (pThr308) Rabbit pAb |
IB |
human, mouse |
124001 |
| Anti-Akt2 Rabbit pAb |
ELISA, IB |
human, mouse, rat |
124002 |
| Anti-PDK1 (1-556) Rabbit pAb |
IB |
human |
ST1115 |
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| | | | Assay Kits |
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| Akt Activity Immunoassay Kit |
124007 |
| K-LISA™ Akt Activity Kit |
CBA019 |
| PhosphoDetect™ Akt (pSer473) ELISA Kit |
CBA005 |
| PhosphoDetect™ Akt (pThr308) ELISA Kit |
CBA004 |
| TruLight™ Akt1/PKBa Kinase Assay Kit |
539705 |
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| | | | Inhibitors |
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| Akt Inhibitor |
124005 |
| Akt Inhibitor II |
124008 |
| Akt Inhibitor III |
124009 |
| Akt Inhibitor IV |
124011 |
| Akt Inhibitor V, Triciribine |
124012 |
| Akt Inhibitor VI, Akt-in |
124013 |
| Akt Inhibitor VII, TAT-Akt-in |
124014 |
| Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 |
124018 |
| InSolution™ Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 |
124017 |
| Akt Inhibitor IX, API-59CJ-OMe |
124019 |
| Akt Inhibitor X |
124020 |
| Akt Inhibitor XI |
124028 |
| PDK1/Akt/Flt Dual Pathway Inhibitor |
521275 |
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| | | | Proteins/Enzymes |
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| Akt1, His•Tag®, Activated, Human, Recombinant, S. frugiperda |
124006 |
| Akt2, GST-Fusion Protein, Human, Recombinant, S. frugiperda |
124021 |
| Akt3, GST-Fusion Protein, Human, Recombinant, S. frugiperda |
124022 |
| PDK1, His•Tag®, Human, Recombinant, S. frugiperda |
521270 |
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| | | | | | Related Resources | | Akt Brochure | | Akt/PKB Interactive Pathway | | Inhibitor Resource | | | | | |
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