Product | Conc. Provided | Comments | Cat. No. |
| InSolution™ AG 1478 | 10 mM
in DMSO | A potent and selective inhibitor of EGF receptor tyrosine kinase (IC50 = 3 nM). | |
| InSolution™ Akt Inhibitor IV | 10 mM
in DMSO | A cell-permeable inhibitor of Akt phosphorylation/ activation. Targets the ATP binding site of a kinase upstream of Akt, but downstream of PI 3-K. | |
InSolution™ Akt Inhibitor
VIII, Isozyme-Selective,
Akti-1/2 | 10 mM
in DMSO | A cell-permeable, potent, and selective inhibitor of Akt1/Akt2 (IC50 = 58 nM, 210 nM, and 2.12 mM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays). | |
| InSolution™ AMPK Inhibitor, Compound C | 10 mM
in DMSO | A cell-permeable, potent, selective, reversible, and ATP-competitive inhibitor of AMPK (Ki = 109 nM in the presence of 5 mM ATP and the absence of AMP). | |
| InSolution™ Bisindolylmaleimide I | 1 mg/ml
in DMSO | A cell-permeable, selective, reversible PKC inhibitor (Ki = 10 nM). | |
| InSolution™ Casein Kinase I Inhibitor, D4476 | 10 mM
in DMSO | A cell-permeable, potent, ATP-competitive inhibitor of CK1 (IC50 = 200 nM from S. pombe; 300 nM for CK1d) and ALK5 (IC50 = 500 nM). | |
| InSolution™ Casein Kinase II Inhibitor I (TBB) | 10 mM
in DMSO | A cell-permeable, selective, ATP/GTP-competitive inhibitor of CK2 (IC50 = 900 nM and 1.6 mM,
using rat liver and human recombinant CK2, respectively) and DYRK (IC50 < 1 mM for DYRK1a). | |
| InSolution™ Casein Kinase II Inhibitor, DMAT | 10 mM
in DMSO | A cell-permeable, potent, high affinity, and ATP-competitive inhibitor of CK2 (IC50 = 140 nM
rat liver; Ki = 40 nM). | |
| InSolution™ Gö 6976 | 500
mg/ml in
DMSO | A cell-permeable inhibitor of PKC (IC50 = 7.9 nM for rat brain). Selectively inhibits Ca2+-dependent PKC a-isozyme (IC50 = 2.3 nM) and PKCbI (IC50 = 6.2 nM). | |
InSolution™ GSK-3
Inhibitor IX (BIO) | 10 mM
in DMSO | A cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3a/b (IC50 = 5 nM). | |
InSolution™ GSK-3b
Inhibitor VIII (AR-AO14418) | 25 mM
in DMSO | A cell-permeable, potent, ATP-competitive inhibitor of GSK-3b (IC50 = 104 nM). | |
InSolution™ H-89,
Dihydrochloride | 10 mM
in DMSO | A cell-permeable, selective, and potent inhibitor of PKA (Ki = 48 nM). | |
| InSolution™ JNK Inhibitor II | 50 mM
in DMSO | A cell-permeable, potent, selective, and reversible inhibitor of c-Jun N-terminal kinase (IC50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). | |
InSolution™ K-252a,
Nocardiopsis sp. | 1 mM in
DMSO | A potent inhibitor of CaM kinase II (Ki = 1.8 nM), MLCK (Ki = 17 nM), PKA (Ki = 18 nM), (Ki = 25 nM), and PKG (Ki = 20 nM). | |
| InSolution™ KN-93 | 5 mM in
DMSO | A cell-permeable inhibitor of rat brain CaM kinase II (Ki = 370 nM). | |
| InSolution™ KT5720 | 2 mM in
DMSO | A cell-permeable, potent, specific inhibitor of PKA (Ki = 56 nM). | |
| InSolution™ LY 294002 | 10 mM
in DMSO | A cell-permeable, potent, and specific PI 3-Kinase inhibitor (IC50 = 1.4 mM) that acts on the ATP-binding site of the enzyme. | |
| InSolution™ ML 3163 | 10 mM
in DMSO | A cell-permeable ATP-competitive inhibitor of p38 MAP kinase (IC50 = 40 mM). Also effectively inhibits the release of TNF-a and IL-1b | |
| InSolution™ Olomoucine | 50 mM
in DMSO | A potent, selective, ATP-competitive inhibitor of p34cdk1/cyclin B (IC50 = 7 mM) and related kinases including p33cdk2/cyclin A (IC50 = 7 mM), p33cdk2/cyclin E (IC50 = 7 mM), p33cdk5/p35 (IC50 = 3 mM), and p44 MAP kinase (IC50 = 25 mM). | |
| InSolution™ p38 MAP Kinase Inhibitor III | 10 mM
in DMSO | A cell-permeable, potent, selective, and ATP competitive p38 MAP kinase inhibitor (IC50 = 380 nM for p38a). | |
| InSolution™ PD 98059 | 5 mg/ml
in DMSO | A cell-permeable, selective inhibitor of MAP kinase kinase (MEK) that acts by inhibiting the activation of MAP kinase and subsequent phosphorylation of MAP kinase substrates. | |
| InSolution™ PD 153035 | 10 mM
in DMSO | A potent and specific inhibitor of the EGF receptor tyrosine kinase (IC50 = 25 pM; Ki = 6 pM). | |
| InSolution™ PD 158780 | 10 mM
in DMSO | A potent inhibitor of the EGFR tyrosine kinase activity (IC50 = 8 pM). | |
| InSolution™ PP2 | 10 mM
in DMSO | A potent and selective inhibitor of the Src family of protein tyrosine kinases. Inhibits p56lck (IC50 = 4 nM), p59fynT (IC50 = 5 nM), and Hck (IC50 = 5 nM). | |
InSolution™ Raf1 Kinase
Inhibitor I | 10 mM
in DMSO | A potent cRaf1 kinase inhibitor (IC50 = 9 nM). | |
| InSolution™ Rapamycin | 5 mM in
DMSO | A selective inhibitor of p70 S6 kinase activation (IC50 = 50 pM). | |
| InSolution™ Ro-31-8220 | 5 mM in
H2o | A cell-permeable, competitive, and selective inhibitor of PKC (IC50 = 10 nM) over CaM kinase II
(IC50 = 17 mM) and PKA (IC50 = 900 nM). Also inhibits GSK-3 in primary adipocytes (IC50 = 6.8 nM). | |
| InSolution™ Roscovitine | 50 mM
in DMSO | A potent, selective, ATP-competitive inhibitor of p34cdk1/cyclin B (IC50 = 650 nM), p33cdk2/ cyclin A (IC50 = 700 nM), p33cdk2/cyclin E (IC50 = 700 nM), and p33cdk5/p35 (IC50 = 200 nM). | |
| InSolution™ SB 202190 | 1 mg/ml
in DMSO | A cell-permeable, potent inhibitor of p38 MAP kinase. Also inhibits the kinase activity of p38b
(IC50 = 16 nM in vitro and 350 nM in cells) and p38 phosphorylation of activating transcription factor 2 (ATF-2; IC50 = 280 nM). | |
| InSolution™ SB 203580 | 1 mg/ml
in DMSO | A cell-permeable, highly specific inhibitor of p38 MAP kinase (IC50 = 34 nM in vitro, 600 nM in cells). | |
| InSolution™ Staurosporine, Streptomyces sp. | 1 mM in
DMSO | A cell-permeable, potent inhibitor of PKA (IC50 = 7 nM), CaM kinase (IC50 = 20 nM), MLCK (IC50 = 1.3 nM), PKC (IC50 = 700 pM), and PKG (IC50 = 8.5 nM). | |
| InSolution™ SU6656 | 10 mM
in DMSO | A potent Src family kinase inhibitor. Inhibits Src (IC50 = 280 nM), Fyn (IC50 = 170 nM), Yes (IC50 = 20 nM) and Lyn (IC50 = 130 nM). | |
| InSolution™ VEGF Receptor 2 Kinase Inhibitor III | 10 mM
in DMSO | A cell-permeable, selective, ATP-competitive inhibitor of VEGF-R and PDGF-R tyrosine kinases
(IC50 = 1.04 mM and 20 mM, respectively, in NIH 3T3 cells overexpressing VEGFR). | |
InSolution™ Rho Kinase
Inhibitor | 10 mM
in DMSO | A cell-permeable, specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated
kinase (ROCK; Ki = 1.6 nM). | |
| InSolution™ Y-27632 | 5 mM in
H2o | A cell-permeable, potent, and selective inhibitor of Rho-associated protein kinases (Ki = 140 nM for p160ROCK). | |
InSolution Inhibitors by Research Area 