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VEGF Interactive Pathway: BAD
 | | |  BAD Antibodies
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| Anti-Bad (19-35) Rabbit pAb |
IB, PS |
bovine, canine, hamster, human, monkey, mouse, ovine, porcine, rabbit, rat |
195872 |
| Anti-Cleaved Bad (Asp61) Rabbit pAb NEW! |
IB |
human |
AP1056 |
| PhosphoDetect™ Anti-Bad (pSer112) (Ab-1) Rabbit pAb |
IB, IP |
human, mouse, rat |
PC518 |
| PhosphoDetect™ Anti-Bad (pSer112) (Ab-3) Rabbit pAb |
IB |
human, mouse, rat |
PC636 |
| PhosphoDetect™ Anti-Bad (pSer136) (Ab-2) Rabbit pAb |
IB |
human, mouse, rat |
PC519 |
| PhosphoDetect™ Anti-Bad (pSer136) (Ab-4) Rabbit pAb |
IB |
human, mouse, rat |
PC637 |
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| | | | Additional Information | | | | | | | | |
| Protein : BAD
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| Connectivity | 99 |
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| Notes | The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. |
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| Hugo ID | 936 |
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| Name | BAD |
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| Description | Bcl-associated death promoter |
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| URN | urn:agi-llid:572 |
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| GO Cellular Component | mitochondrion |
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| | cytoplasm |
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| | mitochondrial outer membrane |
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| Cell Localization | Cytoplasm |
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| | Mitochondria |
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| GO Biological Process | apoptosis |
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| | apoptotic program |
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| | induction of programmed cell death |
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| | glucose catabolism |
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| | glucose homeostasis |
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| | induction of apoptosis |
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| | induction of apoptosis by extracellular signals |
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| | positive regulation of B-cell differentiation |
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| | positive regulation of T-cell differentiation |
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| | regulation of apoptosis |
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| State Description | Transcript Variant: This variant (1) contains an unique 5' UTR region different from that in transcript variant 2. |
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| | Transcript Variant: This variant (2) contains an unique 5'UTR region different from that in transcript variant 1. |
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| Alias | Bad |
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| | Bad v1 |
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| | Bad_v1 |
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| | bcl-2 associated death agonist |
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| | Bad-alpha |
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| | Bbc2 |
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| | Bcl-associated death promoter |
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| | BCL2L8 |
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| | BCL2-antagonist of cell death |
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| | BCL2-binding protein |
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| | BCL2-binding component 6 |
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| | BCL-X/BCL-2 binding protein |
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| | BBC6 |
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| | Bcl- XL/Bcl-2 associated death promoter |
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| | Bcl2-associated death promoter |
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| | BCL2-binding component VI |
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| | BH3-only protein BAD |
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| | BAD protein |
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| Organism | Rattus norvegicus |
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| | Mus musculus |
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| | Human |
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| Pathway | ACH-R in apoptosis |
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| | AKT signaling |
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| | Inhibition of Apoptosis |
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| | Insulin Receptor Signaling |
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| | Antiapoptotic Pathways From IGF-1R |
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| | Mitochondrial control of Apoptosis |
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| | Apoptosis |
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| | AKT signaling |
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