		Technical Resources

		Technical Information

		Calbiochem Information

		Interactive Pathways

		Protein Tyrosine Kinase

		VEGF

VEGF Interactive Pathway: ERK1/2

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Antibodies

Product

Application

Species Reactivity

Cat. No.

Anti-MAP Kinase ERK1 (339-353) (Ab-2) Rabbit pAb IB, IP human, mouse, rat PC54

Anti-MAP Kinase ERK1/ERK2 (333-367) Rabbit pAb IB, IP, PS chicken, clam, Drosophila, frog, human, mouse, rat, sea star, sheep 442675

PhosphoDetect™ Anti-MAP Kinase ERK1/ERK2 (pThr²⁰²/Tyr²⁰⁴) Mouse mAb (12D4) ELISA, IB, IP human, mouse, rat 442706

PhosphoDetect™ Anti-MAP Kinase ERK1/ERK2 (pThr²⁰²/Tyr²⁰⁴) Rabbit pAb DB, IB human, rat 442685

Anti-MAP Kinase ERK1/ERK2 Rabbit pAb FC, IB, PS hamster, human, mouse, rat, zebrafish 442704

Anti-MAP Kinase ERK2, N-Terminal (6-17) Rabbit pAb IB human, mouse, rat, Xenopus, yeast 442680

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Assay Kits

Product

Cat. No.

ERK 1/2 ELISA Kit CBA032

TruLight™ ERK1/2 Assay Kit 539715

PhosphoDetect™ ERK1/2 (pThr¹⁸⁵/pTyr¹⁸⁷) ELISA Kit CBA006

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Inhibitors

Product

Cat. No.

AG 99 658430

ERK Activation Inhibitor Peptide I, Cell-Permeable 328000

ERK Activation Inhibitor Peptide II, Cell-Permeable 328005

ERK Inhibitor 328006

I-OMe-AG 538 658417

5-Iodotubercidin 407900

Kenpaullone 422000

MAP Kinase Antisense Oligonucleotide 454858

MEK1/2 Inhibitor 444939

Sodium Salicylate 567630

SU4984 572625

SU5402 572630

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Peptides/Substrates

Product

Cat. No.

Myelin Basic Protein Peptide Substrate 475920

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Proteins/Enzymes

Product

Cat. No.

Iripallidal, Iris pallida 412500

MAP Kinase 1, His•Tag^®, Human, Recombinant, E. coli 454849

MAP Kinase 2, His•Tag^®, Human, Recombinant, E. coli 454854

[Ala⁷¹]-MAP Kinase ERK1, Inactive, Human, Recombinant, Agarose Conjugate, E. coli 442674

MAP Kinase 2, Activated, Rat, Recombinant, E. coli 454855

MAP Kinase 2, Mouse, Recombinant, E. coli 454850

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Additional Information

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Protein : ERK1 (MAPK3)


Name	ERK1 (MAPK3)
Description	mitogen-activated protein kinase 3
Owner	Public
URN	urn:agi-llid:5595
Connectivity	358
Notes	SUMMARY: kinase involved in intracellular signalling; component of Mapk signalling pathway [RGD]
Hugo ID	6877


Microarray ID	L16532_at
	1387771_a_at
	m61177_s_at
	A_43_P11930
	101834_at
	1427060_at
	msa.12846.0_f_at
	msa.2276.0_s_at
	A_51_P158628
	A_52_P243249
	X60188
	212046_x_at
	1000_at
	X60188_at
	A_23_P37907
	A_23_P37910
	R675
	M393
	OR0838
	OH7890
	766
	MB169
	rc_AI235753_at
	NM_017347
	Msa.2276.0_at
	Z14249
	A_65_P06137
	L0259D09-3
	I_1002466


GenBank ID	AAA36142
	AAH00205
	AAH13992
	AAK52329
	AAK52330
	AJ222708
	AK091009
	AAB19973
	AAH13754
	AAH29712
	AK155287
	BAE33167
	BC013754
	BC029712
	CAA45889
	NC_000073
	NM_011952
	NP_036082
	NT_039433
	Q63844
	S58470
	X64605
	X90997
	Z14249
	AY033607
	AY033608
	BC000205
	BC013992
	BX537897
	CAA42744
	CAA77754
	CAD97888
	M84490
	NC_000016
	NM_002746
	NP_002737
	NT_010393
	NT_089315
	P27361
	X60188
	Z11696
	AAA11604
	AAA20009
	AAA41123
	AAA63486
	AAF71666
	AF155236
	CAA46318
	M38194
	M61177
	NC_005100
	NM_017347
	NP_059043
	NW_047562
	P21708
	S46779
	U12008
	X65198
	15489307
	15489308
	20988619
	20988620
	236372
	236373
	50859
	547569
	50858
	52001483
	51472974
	38257140
	38257141
	51480188
	3273090
	21749281
	20384794
	20384795
	20384796
	20384797
	12652898
	12652899
	15559270
	15559271
	31873912
	31873913
	186695
	186696
	23882
	1335009
	232066
	NW_043970
	XM_234723
	XP_234723
	NT_039564
	XM_285003
	XP_285003
	NT_039625
	XM_285195
	XP_285195
	NT_024812
	XM_055766
	XP_055766
	NW_043396
	31221
	31220
	34860310
	8393330
	8393331
	8050444
	8050445
	204051
	204052
	204053
	204054
	515498
	515499
	56626
	56627
	232067
	51762371
	21489932
	21489933
	984670


Chromosome position	1q36
	16p12-p11.2
	7 61.0 cM


GO ID	GO:0004713
	GO:0005524
	GO:0004674
	GO:0004672
	GO:0016301
	GO:0016740
	GO:0007243
	GO:0007049
	GO:0006468
	GO:0007242
	GO:0007165
	GO:0009887
	GO:0016310
	GO:0045941
	GO:0000189
	GO:0005626
	GO:0005829
	GO:0005737
	GO:0005634
	GO:0000074
	GO:0008372
	0000074
	0000166
	0004674
	0004707
	0005524
	0006468
	0008372
	0016740
	0001784
	0004672
	0004713
	0005515
	0005634
	0005737
	0006974
	0007049
	0007165
	0009887
	0016301
	0016310
	0045941
	0000189
	0004682
	0004691
	0005626
	0005829
	0007242
	0007243
	GO:0004707
	GO:0004691
	GO:0004682


Alias	similar to microtubule-associated protein-2 kinase
	similar to extracellular signal-regulated kinase 1
	similar to extracellular signal-regulated kinase I
	similar to extracellular signal-related kinase 1c
	kinase, mitogen-activated 3 (MAP kinase 3; p44)
	Scl23
	Lil2
	Lipid Level QTL 2
	Lipid Level QTL II
	Serum phospholipid level QTL 1
	Serum phospholipid level QTL I
	p44
	Erk-1
	MNK1
	protein kinase, mitogen activated 3 (extracellular-signal-regulated kinase 1, ERK1)
	mitogen activated kinase 3
	Protein kinase mitogen activated 3 (extracellular-signal-regulated kinase 1 ERK1)
	protein kinase, mitogen activated kinase 3
	mitogen-activated protein kinase 3
	protein kinase, mitogen-activated 3 (MAP kinase 3; p44)
	extracellular-signal-regulated kinase 1
	p44 mitogen activated protein kinase
	Extracellular signal-regulated kinase I
	rMNK1
	mitogen activated protein kinase III
	Microtubule-associated protein-2 kinase
	p44 ERK
	ERK I
	mitogen-activated 3
	mitogen-activated III
	mitogen-activated 3 (map kinase 3; p44)
	ERK1
	ERT2
	Esrk1
	Extracellular signal-regulated kinase 1
	Insulin-stimulated MAP2 kinase
	MAP kinase 3
	p44 MAP kinase
	p44/42 mapk
	p44mapk
	PRKM3
	protein kinase, mitogen-activated 3
	MAPK p44
	mitogen activated protein kinase 3
	protein kinase, mitogen-activated 3 (MAP kinase 3, p44)
	MAP kinase III
	protein kinase, mitogen-activated III
	MAPK3
	p44erk1
	p44erk I
	Esrk I
	extracellular signal-related kinase 1c


Organism	Rattus norvegicus
	Mus musculus
	Homo sapiens
	Human


MedLine Reference	11684667
	11726647
	11841548
	12223545
	12466851
	14636584
	15383658
	15544353
	7687743
	12072413
	12097495
	9779826


LocusLink ID	326417
	299498
	328173
	328715
	19095
	5595
	26417
	50689


FunctionalClass	ATP binding
	MAP kinase
	nucleotide binding
	protein serine/threonine kinase
	transferase
	kinase
	phosphotyrosine binding
	protein binding
	protein kinase
	protein-tyrosine kinase
	cAMP-dependent protein kinase
	protein kinase CK2


RGD ID	3046
	61408


Hugo Symbol	MAPK3


Unigene ID	Rn.2592
	Mm.8385
	Hs.861


Keyword	map kinase
	ERK activator kinase
	RAS small monomeric GTPase
	SAP kinase
	protein serine/threonine kinase
	nicotinic acetylcholine receptor
	kinase inhibitor
	map kinases
	map kinase kinase
	nuclei
	nucleus
	FAK


GO Cellular Component	cytosol
	insoluble fraction
	cytoplasm
	nucleus
	cellular component unknown
	cellular_component unknown


GO Molecular Function	MAP kinase activity
	cAMP-dependent protein kinase activity
	protein kinase CK2 activity
	protein-tyrosine kinase activity
	ATP binding
	protein serine/threonine kinase activity
	protein kinase activity
	kinase activity
	transferase activity
	ATP binding activity
	protein tyrosine kinase activity


Cell Localization	Nucleus
	Cytoplasm


Pathway	p40 MAPK
	Erk-PI3K in Collagen Binding
	CREB signaling
	Antiapoptotic Pathways From IGF-1R
	MAPK-ERK in Growth and Differentiation
	Integrin Signaling
	G-protein Coupled Receptor signaling
	Apoptosis
	Mitochondrial control of Apoptosis
	Inhibition of Apoptosis
	TGF-beta signaling
	ACVR1B -> JUNB signalling pathway
	ACVR1B -> MADH7 signalling pathway
	ACVRL1 -> MADH2 signalling pathway
	NTRK3 -> JUN signalling pathway
	NTRK3 -> STAT5A signalling pathway
	NTRK3 -> TAL1 signalling pathway
	TLR4 -> CEBPA signalling pathway
	IGF1R -> SREBF1 signalling pathway
	IGF1R -> CEBPA signalling pathway
	IL4R -> MYC signalling pathway
	IL4R -> GATA3 signalling pathway
	KLRG1 -> FOS signalling pathway
	ITGB1 -> MYC signalling pathway
	KDR -> ETS1 signalling pathway
	KDR -> TAL1 signalling pathway
	KIT -> FOS signalling pathway
	KIT -> TAL1 signalling pathway
	CD2 -> MYC signalling pathway
	CD2 -> IRF1 signalling pathway
	CD14 -> ICSBP1 signalling pathway
	CD19 -> JUND signalling pathway
	TNFRSF5 -> JUND signalling pathway
	EPHA4 -> JUN signalling pathway
	ERBB2 -> HIF1A signalling pathway
	ERBB2 -> ETS2 signalling pathway
	ERBB2 -> ETV1 signalling pathway
	ERBB2 -> ETV4 signalling pathway
	ERBB2 -> SP1 signalling pathway
	ERBB2 -> MADH7 signalling pathway
	ERBB4 -> ATF4 signalling pathway
	ERBB4 -> STAT5A signalling pathway
	FGFR3 -> SOX9 signalling pathway
	FLT3 -> CEBPA signalling pathway
	SPN -> MYC signalling pathway
	SPN -> TCF3 signalling pathway
	SSTR3 -> TP53 signalling pathway
	TACR1 -> CREB1 signalling pathway
	PTPRC -> BCL6 signalling pathway
	RET -> JUND signalling pathway
	EGFR -> JUN signalling pathway
	MET -> ETS1 signalling pathway
	MET -> TAL1 signalling pathway
	MET -> MADH2 signalling pathway
	MPL -> CEBPA signalling pathway
	AGT-LRP2
	AREG-EGFR
	BDNF-NCAM1
	BDNF-NGFR
	BDNF-NTRK1
	BDNF-NTRK2
	BDNF-NTRK3
	BMP4-ACVR1
	BMP4-BMPR1A
	BMP4-BMPR1B
	BMP4-BMPR2
	BMP7-ACVR1
	BMP7-ACVR2
	BMP7-ACVR2B
	BMP7-BMPR1A
	BMP7-BMPR1B
	BMP7-BMPR2
	BTC-EGFR
	CCL19-CD44
	CCL19-IL2RA
	CCL19-IL2RB
	CCL2-CD4
	CCL22-VCAM1
	CCL4-CD4
	CCL4-TNFRSF8
	CD86-CD28
	CD86-CD80
	CD86-CR1
	CD86-CR2
	CD86-TNFRSF5
	CLC-CNTFR
	CLC-IL6ST
	CNTF-CNTFR
	CNTF-IL6ST
	CNTF-LIFR
	CSF1-CSF1R
	CSF1-IL6R
	CSF1-TNFRSF5
	CSF2-CSF2RA
	CSF3-CSF3R
	CSF3-IL6R
	CTF1-IL6ST
	DTR-CD44
	DTR-EGFR
	DTR-ERBB4
	EFNB1-EPHB2
	EFNB1-FGFR2
	EGF-EGFR
	EGF-ERBB2
	EGF-ERBB3
	EGF-ERBB4
	EGF-LRP8
	EGF-NGFR
	EPO-EPOR
	F2-ITGAV
	F2-LRP1
	F2-LRP2
	F2-THBD
	FGF1-FGFR1
	FGF1-FGFR2
	FGF1-FGFR3
	FGF1-GPC1
	FGF10-FGFR2
	FGF2-CD44
	FGF2-FGFR1
	FGF2-FGFR2
	FGF2-FGFR3
	FGF2-GPC1
	FGF2-TGFBR3
	FGF4-CD44
	FGF4-FGFR2
	FGF7-FGFR2
	FGF7-GPC1
	FGF8-FGFR3
	FGF9-FGFR3
	FIGF-FLT4
	FIGF-KDR
	GDNF-RET
	GH1-GHR
	GH1-IGF1R
	GH1-PRLR
	GRO1-EGFR
	HGF-CD44
	HGF-FGFR2
	HGF-IL6R
	HGF-MET
	IFNA1-CR2
	IFNA1-IFNAR1
	IFNA1-IFNAR2
	IFNG-HLA-C
	IFNG-IFNGR1
	IFNG-IFNGR2
	IGF1-BST1
	IGF1-IGF1R
	IGF1-IGF2R
	IGF1-LRP5
	IGF2-IGF1R
	IGF2-IGF2R
	IL10-IL10RA
	IL10-TNFRSF7
	IL11-IL6R
	IL11-IL6ST
	IL13-IL13RA1
	IL13-IL13RA2
	IL13-IL2RG
	IL13-IL4R
	IL15-IL15RA
	IL15-IL2RB
	IL15-IL2RG
	IL16-CD4
	IL17-IL17R
	IL1A-IL1R1
	IL1A-IL1RAP
	IL1B-HLA-DRB1
	IL1B-IL1R1
	IL1B-IL1RAP
	IL1B-IL6R
	IL2-IL15RA
	IL2-IL2RA
	IL2-IL2RB
	IL2-IL2RG
	IL2-IL4R
	IL21-IL2RG
	IL3-CD8A
	IL3-CSF2RB2
	IL3-EPOR
	IL3-IL3RA
	IL4-FCER2
	IL4-IL2RG
	IL4-IL4R
	IL5-IL5RA
	IL5-IL6ST
	IL6-IL6R
	IL6-IL6ST
	IL6-LIFR
	IL6-TNFRSF5
	IL7-IL2RG
	IL7-IL7R
	INHBA-ACVR1B
	INHBA-ACVR2
	INHBA-ACVR2B
	INHBA-ACVRL1
	INS-EGFR
	INS-HLA-DRB1
	INS-IGF1R
	INS-TFRC
	KITLG-KIT
	LEP-LEPR
	LEP-LRP2
	LIF-IGF2R
	LIF-IL6ST
	LIF-LIFR
	MDK-ITGB1
	MDK-LRP2
	NGFB-NGFR
	NGFB-NTRK1
	NGFB-NTRK2
	NGFB-NTRK3
	NPPA-NPTXR
	NRG1-CD44
	NRG1-EGFR
	NRG1-ERBB2
	NRG1-ERBB3
	NRG1-ERBB4
	NTF3-CNTFR
	NTF3-NGFR
	NTF3-NTRK1
	NTF3-NTRK2
	NTF3-NTRK3
	NTF5-NGFR
	NTF5-NTRK1
	NTF5-NTRK2
	NTF5-NTRK3
	OSM-CD22
	OSM-IL6ST
	OSM-LIFR
	PDGFA-PDGFRB
	PGF-FLT1
	PGF-KDR
	PRL-PRLR
	PTH-IL6ST
	SDF1-CD4
	SDF1-IL6ST
	SELPLG-ICAM1
	SELPLG-ITGA2B
	SELPLG-SELL
	SEMA3A-PLXNB1
	SEMA3A-PLXNC1
	SPP1-CD44
	SPP1-ITGAV
	TAC1-TNFRSF11B
	TGFA-EGFR
	TGFB1-ACVR1
	TGFB1-ACVR1B
	TGFB1-ACVR2
	TGFB1-ACVR2B
	TGFB1-ACVRL1
	TGFB1-BMPR1B
	TGFB1-CD44
	TGFB1-IGF2R
	TGFB1-IL6R
	TGFB1-M6PR
	TGFB1-SELE
	TGFB1-SELL
	TGFB1-TGFBR1
	TGFB1-TGFBR2
	TGFB1-TGFBR3
	THBS1-CD36
	THBS1-ITGB1
	THBS1-VLDLR
	THPO-EPOR
	THPO-MPL
	TNF-IL15RA
	TNF-NGFR
	TNF-TNFRSF1A
	TNF-TNFRSF1B
	TNF-TNFRSF6
	TNFSF10-TNFRSF10A
	TNFSF10-TNFRSF10B
	TNFSF10-TNFRSF1A
	TNFSF10-TNFRSF6
	TNFSF11-TNFRSF11A
	TNFSF11-TNFRSF11B
	TNFSF5-CD28
	TNFSF5-CD80
	TNFSF5-TNFRSF5
	TNFSF5-TNFRSF6
	TNFSF5-TNFRSF7
	TNFSF5-TNFRSF8
	VEGF-CD44
	VEGF-EGFR
	VEGF-FLT1
	VEGF-FLT4
	VEGF-GPC1
	VEGF-IL1R1
	VEGF-KDR
	CB0479 MAPK
	CB0480 Insulin


GO Biological Process	intracellular signaling cascade
	nuclear translocation of MAPK
	positive regulation of transcription
	protein kinase cascade
	cell cycle
	organogenesis
	phosphorylation
	response to DNA damage stimulus
	signal transduction
	protein amino acid phosphorylation
	regulation of progression through cell cycle
	regulation of cell cycle


Group	Kinases


EC Number	2.7.1.37
	2.7.1.-


State	p


MGI ID	1346859


Swiss-Prot Accession	P27361


OMIM ID	601795
	61408
	OMIM:601795


Source	Curated
	BIND
	ResNet

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