		Technical Resources

		Technical Information

		Calbiochem Information

		Interactive Pathways

		Protein Tyrosine Kinase

		VEGF

VEGF Interactive Pathway: MEK 1/2

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Antibodies

Product

Application

Species Reactivity

Cat. No.

PhosphoDetect™ Anti-MEK1 (pSer²⁹⁸) Rabbit pAb IB human, mouse, rat ST1015

Anti-MEK1, N-Terminal (1-12) Rabbit pAb IB, IH, IP human, mouse, rat, Xenopus 444942

PhosphoDetect™ Anti-MEK1/2 (pThr²⁹²) Rabbit pAb DB, ELISA, IB, IH human ST1001

PhosphoDetect™ Anti-MEK1/2 (pThr³⁸⁶) Rabbit pAb DB, IB human ST1002

PhosphoDetect™ Anti-MEK1/MEK2 (pSer^218/222) Rabbit pAb DB, ELISA, IB human 444955

Anti-MEK2 (1-13) Rabbit pAb IB human, mouse, rat, Xenopus, yeast 444949

PhosphoDetect™ Anti-MEK2 (pThr³⁹⁴) Rabbit pAb IB human ST1016

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Assay Kits

Product

Cat. No.

PhosphoDetect™ MEK1 (pSer^218/222) ELISA Kit CBA030

MEK1 ELISA Kit CBA070

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� Inhibitors

Product

Cat. No.

ERK Activation Inhibitor Peptide I, Cell-Permeable 328000

ERK Activation Inhibitor Peptide II, Cell-Permeable 328005

MEK Inhibitor II 444938

MEK1/2 Inhibitor 444939

U0125 662008

U0126 662005

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� Peptides/Substrates

Product

Cat. No.

[Ala⁷¹]-MAP Kinase ERK1, Inactive, Human, Recombinant, Agarose Conjugate, E. coli 442674

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� Protein/Enzymes

Product

Cat. No.

MEK1, GST-Fusion, Human, Recombinant, E. coli 475702

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Additional Information

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Protein : MEK2 (MAP2K2)


Name	MEK2 (MAP2K2)
Description	MAPK/Erk Kinase 2; Mitogen-Activated PRotein Kinase Kinase 2; Protein Kinase, Mitogen-activated, Kinase 2. Mek2 is downstream of Raf and upon activation can activate extracellular signal-regulated kinases (ERKs). OMIM: 601263.
Owner	Public
URN	urn:agi-llid:5605
Connectivity	43
Notes	The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax.
Hugo ID	6842


Microarray ID	1398834_at
	l14936_at
	rc_aa957896_s_at
	rc_aa963674_g_at
	A_42_P653827
	1415974_at
	aa472313_s_at
	msa.17267.0_f_at
	msa.5815.0_s_at
	msa.7301.0_s_at
	A_51_P439626
	L11285
	223685_s_at
	213487_at
	213490_s_at
	32519_at
	58848_at
	80459_at
	202424_at
	1131_at
	L11285_at
	A_23_P208839
	A_14_P106299
	A_14_P118247
	A_23_P208835
	C286
	OH8080
	R724
	R613
	OR0879
	MB171
	A_51_P123253
	A_52_P26086


GenBank ID	NP_075627
	NT_039496
	Q63932
	S68267
	AAA41620
	BAA03442
	D14592
	L14936
	NC_005106
	NM_133283
	NP_579817
	NW_047773
	P36506
	AAH00471
	AAH18645
	AK093125
	BC000471
	BC018645
	BX538081
	CAD98005
	L11285
	NC_000019
	NM_030662
	NP_109587
	NR_002144
	NT_011255
	NT_086894
	P36507
	AAP70765
	51830781
	22129004
	22129005
	38080535
	18479557
	18479558
	32027311
	32027312
	34863151
	18959213
	18959214
	26348610
	26348611
	15990387
	15990388
	545202
	545203
	2499629
	37552371
	21614527
	13489054
	51475033
	21751896
	33875487
	12653403
	33879024
	17391417
	31874213
	31874214
	307184
	547915
	AY073130
	NT_039624
	NM_146958
	NP_667169
	NT_082357
	AAL60793
	AY317255
	286229
	303804
	349544
	349545
	547916
	51765774
	31581583
	31560267
	12844162
	12844163
	26331723
	26331724
	AAC60678
	AAH14830
	AK009392
	AK036822
	AK080574
	AK138130
	AK140101
	AK143425
	AK171584
	AK172055
	AK176974
	AK186012
	AK192399
	AK202988
	AK208021
	AK212487
	AK216389
	AK217783
	BAB26261
	BAC29592
	BAC37945
	BAE24237
	BAE25372
	BAE42542
	BAE42803
	BC014830
	NC_000076
	NM_023138


Chromosome position	7q11
	19p13.3
	10 43.0 cM


GO ID	0004930
	0004984
	0004872
	0007186
	0007608
	0016021
	0004672
	0016301
	0000166
	0004674
	0004713
	0005524
	0005576
	0006468
	0016740


Alias	dual specificity
	kinase, mitogen activated, kinase 2, p
	Olfr171
	GA_x54KRFPKG5P-16071018-16070077
	MOR273 I
	MOR273-1
	MOR273-5
	olfactory receptor 171
	olfactory receptor MOR273 I
	olfactory receptor MOR273-1
	mitogen activated protein kinase kinase 2
	MK2
	MAPK kinase 2
	MAP kinase/Erk kinase
	Dual specificity mitogen-activated protein kinase kinase 2
	ERK activator kinase 2
	ERK kinase 2
	MAPKK2
	MEK2
	mitogen-activated protein kinase kinase 2
	mitogen-activated protein kinase kinase 2, p45
	MKK2
	Dual specificity mitogen-activated protein kinase kinase II
	MAPK/ERK kinase II
	mitogen-activated protein kinase kinase II
	ERK activator kinase II
	Map2k2
	MAPK/ERK kinase 2
	p45 MAPKK
	MAPK kinase II
	PRKMK2s
	MAPKK2s
	p45 MAPK kinase
	ERK kinase II
	PRKMK2
	protein kinase, mitogen activated, kinase 2, p45
	MAP kinase kinase II
	MAP kinase kinase 2


Organism	Mus musculus
	Homo sapiens
	Rattus norvegicus
	Human


MedLine Reference	8388392


LocusLink ID	58960
	19102
	29570
	5605
	26396
	103107
	258960


FunctionalClass	kinase
	protein kinase
	ATP binding
	nucleotide binding
	protein serine/threonine kinase
	protein-tyrosine kinase
	transferase


RGD ID	61888


Hugo Symbol	MAP2K2


Unigene ID	Rn.82693
	Mm.275436
	Hs.465627
	Hs.366546


GO Cellular Component	extracellular region
	integral to membrane
	extracellular


Cell Localization	Cytoplasm
	Extracellular


Pathway	p40 MAPK
	MAPK-ERK in Growth and Differentiation
	Insulin Receptor Signaling
	Integrin Signaling
	G-protein Coupled Receptor signaling
	NTRK1 -> MADH3 signalling pathway
	NTRK2 -> CREB1 signalling pathway
	NTRK3 -> JUN signalling pathway
	OPRM1 -> JUNB signalling pathway
	TGFBR1 -> SP1 signalling pathway
	TLR4 -> EGR1 signalling pathway
	ADORA1 -> FOS signalling pathway
	AGTR1 -> FOS signalling pathway
	AGTR1 -> CREB1 signalling pathway
	AGTR1 -> MADH2 signalling pathway
	AGTR2 -> FOS signalling pathway
	AGTR2 -> CREB1 signalling pathway
	VCAM1 -> RELA signalling pathway
	ICAM1 -> ETS1 signalling pathway
	ICAM1 -> FOS signalling pathway
	TNFRSF6 -> FOS signalling pathway
	TNFRSF6 -> SRF signalling pathway
	TNFRSF6 -> DDIT3 signalling pathway
	TNFRSF6 -> E2F1 signalling pathway
	TNFRSF6 -> RELA signalling pathway
	IFNAR1 -> CDX2 signalling pathway
	IL2RB -> FOS signalling pathway
	IL7R -> TCF3 signalling pathway
	CD4 -> STAT1 signalling pathway
	CD4 -> MADH3 signalling pathway
	CD38 -> TCF3 signalling pathway
	TNFRSF5 -> JUNB signalling pathway
	EPHA4 -> JUN signalling pathway
	EPOR -> FOS signalling pathway
	ERBB4 -> ATF4 signalling pathway
	F2R -> SRF signalling pathway
	F2R -> CREB1 signalling pathway
	FCGR2B -> GATA4 signalling pathway
	FGFR2 -> FOS signalling pathway
	FSHR -> FOS signalling pathway
	GPR9 -> RELA signalling pathway
	GRIA2 -> FOS signalling pathway
	GRIA3 -> FOS signalling pathway
	PLAUR -> FOS signalling pathway
	PTPRC -> NFATC2 signalling pathway
	DRD2 -> FOS signalling pathway
	DRD2 -> CREB1 signalling pathway
	DRD2 -> EGR1 signalling pathway
	MC1R -> MADH4 signalling pathway
	MC1R -> MITF signalling pathway
	MET -> MAX signalling pathway
	AGT-LRP2
	CSF1-CSF1R
	CSF1-IL6R
	CSF1-TNFRSF5
	CSF2-CSF2RA
	CTF1-IL6ST
	DTR-EGFR
	EGF-EGFR
	EGF-ERBB2
	EGF-ERBB3
	EGF-ERBB4
	EGF-LRP8
	EGF-NGFR
	FGF1-FGFR1
	FGF1-FGFR2
	FGF1-FGFR3
	FGF1-GPC1
	FGF2-CD44
	FGF2-FGFR1
	FGF2-FGFR2
	FGF2-FGFR3
	FGF2-GPC1
	FGF2-TGFBR3
	GRO1-EGFR
	HGF-CD44
	HGF-FGFR2
	HGF-IL6R
	HGF-MET
	IGF1-BST1
	IGF1-IGF1R
	IGF1-IGF2R
	IGF1-LRP5
	IGF2-IGF1R
	IGF2-IGF2R
	IL1B-HLA-DRB1
	IL1B-IL1R1
	IL1B-IL1RAP
	IL1B-IL6R
	IL4-FCER2
	IL4-IL2RG
	IL4-IL4R
	IL6-IL6R
	IL6-IL6ST
	IL6-LIFR
	IL6-TNFRSF5
	INS-EGFR
	INS-HLA-DRB1
	INS-IGF1R
	INS-TFRC
	KITLG-KIT
	LIF-IGF2R
	LIF-IL6ST
	LIF-LIFR
	NGFB-NGFR
	NGFB-NTRK1
	NGFB-NTRK2
	NGFB-NTRK3
	OSM-CD22
	OSM-IL6ST
	OSM-LIFR
	PRL-PRLR
	SDF1-CD4
	SDF1-IL6ST
	TNF-IL15RA
	TNF-NGFR
	TNF-TNFRSF1A
	TNF-TNFRSF1B
	TNF-TNFRSF6
	CB0479 MAPK
	CB0480 Insulin


GO Biological Process	protein amino acid phosphorylation
	G-protein coupled receptor protein signaling pathway
	perception of smell


Group	Kinases


EC Number	2.7.1.-


MGI ID	1346867
	3030005


Swiss-Prot Accession	P36507


OMIM ID	601263
	OMIM:601263


Source	Curated
	BIND