		Technical Resources

		Technical Information

		Calbiochem Information

		Interactive Pathways

		Protein Tyrosine Kinase

		VEGF

VEGF Interactive Pathway: PKC

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PKC Antibodies

Product

Application

Species Reactivity

Cat. No.

Anti-PKC_bII (660-673) Rabbit pAb ELISA, IB, IC, IF rat 539526

Anti-PKC (a, b, g) Mouse mAb (M110) ELISA, IB, IC, IP human, mouse, rat PK1014

Anti-PKC (Ab-1) Rabbit pAb IB, IF chicken, human, mouse PC20

Anti-PKC (Ab-2) Mouse mAb (MC5) IB, IP, NT, PS bovine, human, mouse, rat OP74

Anti-PKC_Consensus (Ac543-550) Rabbit pAb ELISA, IB, IC, IF, IP bovine, human, mouse, rabbit, rat 539550

Anti-PKC_a (662-672) Rabbit pAb IB mammalian 539601

Anti-PKC_a/b (371-388) Rabbit pAb Rabbit pAb ELISA, IB, IP bovine, canine, chicken, Drosophila, human, monkey, mouse, ovine, porcine, rabbit, rat, Xenopus 539507

Anti-PKC_bI (661-671) Rabbit pAb ELISA, IB, IF rat 539523

Anti-PKC_bI (661-671) Rabbit pAb IB mammalian 539603

Anti-PKC_bII (661-673) Rabbit pAb IB mammalian 539605

Anti-PKC_d (658-676) Rabbit pAb IB mammalian 539607

Anti-PKC_d (662-673) Rabbit pAb ELISA, IB rat 539532

PhosphoDetect™ Anti-PKC_d (pTyr³¹¹) Rabbit pAb IB mouse, rat ST1019

Anti-PKC_e (721-737) Rabbit pAb IB mammalian 539609

Anti-PKC_e (728-737) Rabbit pAb ELISA, IB, IF rat 539535

Anti-PKC_g (306 - 318) Rabbit pAb ELISA, IB, IF bovine, human, rabbit, rat 539529

Anti-PKC_g (681-697) Rabbit pAb IB mammalian 539611

Anti-PKC_z (580-592) Rabbit pAb ELISA, IB, IF rat 539538

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PKC Activators

Product

Cat. No.

a-Amyloid Precursor Protein Modulator 565740

Bryostatin 2 203812

1,2-Dioctanoyl-sn-glycerol 317505

Lipoxin A₄ 437720

Lyngbyatoxin A, Micromonospora sp. 440230

Oleic Acid 4954

1-Oleoyl-2-acetyl-sn-glycerol 495414

4a-Phorbol 524382

Phorbol-12,13-dibutyrate 524390

Phorbol-12,13-didecanoate 524392

4a-Phorbol-12,13-didecanoate 524394

Phorbol-12-myristate-13-acetate 524400

L-a-Phosphatidylinositol-3,4-bisphosphate, Dipalmitoyl-, Pentaammonium Salt 524613

L-a-Phosphatidylinositol-4,5-bisphosphate, Dipalmitoyl-, Pentaammonium Salt 524614

L-a-Phosphatidylinositol-3,4,5-trisphosphate, Dipalmitoyl-, Heptaammonium Salt 524615

1-Stearoyl-2-arachidonoyl-sn-glycerol 569399

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PKC Assay Kits

Product

Format

Form

Sensitivity

Assay Range

Assay Time

Sample Type

Cat. No.

Protein Kinase Assay Kit, Non-Radioactive 96-well plate 96 Tests Cell lysates, purified enzymes 539484

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PKC Enzymes

Product

Cat. No.

PKC, Catalytic Subunit, Rat Brain 539513

PKC_q, His•Tag^®, Human, Recombinant, S. frugiperda 539677

PKC, Human, Recombinant, S. frugiperda 539673

PKC, Rat Brain 539494

PKC_bI, Human, Recombinant, S. frugiperda 539655

PKCbII, His·Tag®, Human, Recombinant, S. frugiperda 539658

PKCbII, Human, Recombinant, S. frugiperda 539657

PKCg, Human, Recombinant, S. frugiperda 539665

PKCd, His·Tag®, Human, Recombinant, S. frugiperda 539678

PKCd, Human, Recombinant, S. frugiperda 539672

PKCe, Human, Recombinant, S. frugiperda 539660

PKCe, GST-Fusion, Human, Recombinant, S. frugiperda 539691

Protein Kinase C Isozyme Sampler Set 539674

PKCa, His•Tag^®, Human, Recombinant, S. frugiperda 539651

Protein Kinase C_a, Human, Recombinant, S. frugiperda 539650

Protein Kinase C_z, His·Tag^®, Human, Recombinant, S. frugiperda 539679

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PKC Inhibitors

Product

Cat. No.

Bisindolylmaleimide I 203290

Bisindolylmaleimide I, Hydrochloride 203291

InSolution™ Bisindolylmaleimide I 203293

Bisindolylmaleimide II 203292

Bisindolylmaleimide III, Hydrochloride 203294

Bisindolylmaleimide IV 203297

Bisindolylmaleimide V 203303

Calphostin C, Cladosporium cladosporioides 208725

Cardiotoxin, Naja nigricollis 217504

Chelerythrine Chloride 220285

Dequalinium Chloride 263225

Ellagic Acid, Dihydrate 324683

Gö 6976 365250

InSolution™ Gö 6976 365253

Gö 6983 365251

Gö 7874, Hydrochloride 365252

H-7, Dihydrochloride 371955

Iso-H-7, Dihydrochloride 371956

HBDDE 372770

Hispidin 377980

Hypericin 400076

K-252a, Nocardiopsis sp. 420298

InSolution™ K-252a, Nocardiopsis sp. 420297

K-252b, Nocardiopsis sp. 420319

K-252c 420305

Melittin 444605

NGIC-I 481500

Phloretin 524488

Piceatannol 527948

PKC 20-28, Cell-Permeable, Myristoylated 476480

PKC Inhibitor Peptide 19-31 05-23-4904

PKC Inhibitor Peptide 19-36 539560

PKC_h Pseudosubstrate Inhibitor, Myristoylated 539604

PKC Inhibitor, EGF-R Fragment 651-658, Myristoylated 476475

PKC_b Inhibitor 539654

PKC_bII/EGFR Inhibitor 539652

PKC_e Translocation Inhibitor Peptide 539522

PKC_e Translocation Inhibitor Peptide, Negative Control 539542

PKC_q Pseudosubstrate Inhibitor 539634

PKC_q Pseudosubstrate Inhibitor, Myristoylated 539636

PKC_z Pseudosubstrate Inhibitor, Myristoylated 539624

PKC_z/i Pseudosubstrate Inhibitor 539610

Polymyxin B Sulfate 5291

Ro 31-7549, Immobilized 557509

Ro-31-7549 557508

Ro-31-8220 557520

InSolution™ Ro-31-8220 557521

Ro-31-8425 557514

Ro-32-0432 557525

Rottlerin 557370

Safingol 559300

Sangivamycin 559307

Scytonemin, Lyngbya sp. 565715

D-erythro-Sphingosine, Dihydro- 300230

D-erythro-Sphingosine, Free Base, High Purity 567726

D-erythro-Sphingosine, N,N-Dimethyl- 310500

Staurosporine, N-Benzoyl 539648

Staurosporine, Streptomyces sp. 569397

Tamoxifen Citrate 579000

Tamoxifen, 4-Hydroxy-, (Z)- 579002

TER14687 581800

UCN-01 539644

UCN-02 539645

Vitamin E Succinate 679130

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PKC Peptides, Probes, and Substrates

Product

Cat. No.

4EBP1/PHAS-I, Rat, Recombinant 516675

Histone H1, Calf Thymus 382150

MARCKS PSD-Derived Peptide, PKC Substrate 454880

Protein Kinase C Selectide™ Substrate 527151

PKC Substrate, MBP 4-14 539492

PKC_d Peptide Substrate 539563

PKC_e Peptide Substrate 539562

PKC_h Substrate, Biotinylated 539666

PKC_z Substrate, Biotinylated 539667

PKC_m Peptide Substrate 539564

Protein Kinase C_q Substrate, Biotinylated 539668

RIM-1 557325

Syntide 2 05-23-4910

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PKC Recombinant Standards

Product

Cat. No.

PKC_bI Standard, Human, Recombinant, S. frugiperda 539619

PKCg Standard, Human, Recombinant, S. frugiperda 539627

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Additional Information

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Protein : PRKCD


Name	PRKCD
Description	protein kinase C, delta
Owner	Public
URN	urn:agi-llid:5580
Connectivity	273
Notes	Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. Activation is required for oxidant-induced disruption of both the microtubule cytoskeleton and permeability barrier of intestinal epithelia. Calcium-dependent involucrin expression is inversely regulated by protein kinase C (PKC)alpha and PKCdelta. Data show that activation of protein kinase D in response to oxidative stress requires two sequential signaling events, mediated by protein kinase Cdelta. Data show that protein kinase C delta (PKC delta) is located downstream of RhoA and that active RhoA and PKCdelta are both necessary for leukotriene D(4)-induced stress-fibre formation. Data suggest that phosphorylation of protein kinase C delta may act as a negative feedback mechanism to limit the overall activation of the CD98 pathway. Down-regulation of hydrogen peroxide-induced activation of this enzyme in N-acetylglucosaminyltransferase III-transfected HeLaS3 cells. EGF-mediated induction of fibronectin expression occurs at the post-transcriptional level and involves PKCdelta signaling pathway. HSP25 downregulates PKCdelta, which is a key molecule for radiation-induced ROS generation and mitochondrial-mediated caspase-dependent apoptotic events. Il-2 and polysaccharide K increased expression of protein kinase C delta. Induction of neurites by the regulatory domain of PKCD is counteracted by PKC catalytic activity and RhoA GTP-binding protein metabolism. Inhibition of PKCdelta is sufficient to lead to caspase-3-independent apoptosis in the colon cancer line, COLO 205. Interleukin-7 and transforming growth factor-beta play counter-regulatory roles in protein kinase C-delta-dependent control of fibroblast collagen synthesis in pulmonary fibrosis. Involvement of c-Src and protein kinase C delta in the inhibition of Cl(-)/OH- exchange activity in Caco-2 cells by serotonin. MARCKS-mediated neurotensin release occurs via protein kinase C-delta downstream of the Rho/ROK pathway. MMP-9 inhibition activity of resveratrol and its inhibition of JNK and PKC-delta may have a therapeutic potential in cancer. Mediation of tumor growth factor beta-1 induced collagen I expression in glomerular mesangial cells. NAG-1 expression is up-regulated by TPA in LNCaP cells through a PKC-dependent pathway involving the activation of NF-kappa B. Novel isoforms regulate human keratinocyte differentiation by activating a p38 delta mitogen-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha. Overexpression of dominant-negative PKCdelta mutant supported an essential role in virus reactivation, yet overexpression of PKCdelta alone was not sufficient to induce lytic reactivation of KSHV. PKC delta (nPKC delta) might be predominantly involved in regulating membrane functions and survival of neutrophils associated with post ischemia reperfusion injury-induced inflammatory oxidative stress. PKC delta associates with IL6ST via Stat3 and enhances Stat3-gp130 interaction. PKC delta expressed in human neutrophils can phosphorylate p47phox and induce both its translocation and NADPH oxidase activation as well as the binding of p47phox to the cytosolic fragment of p22phox. PKC delta has a role in activating p53 transcription. PKC delta is activated in a retinoic acid-dependent manner and plays a critical role in the generation of the biological effects of retinoic acid in malignant cells. PKC delta regulates airway epithelial cell expression of NF-kappa B-dependent proinflammatory genes IL-8, GM-CSF, RANTES, and ICAM-1. PKC epsilon and delta are the main PKC isozymes involved in G alpha(q)-mediated signaling in human atria. PKC mediates VEGF-induced Akt activation in a novel signal transduction pathway through which Akt can be regulated by growth factors acting through receptor protein tyrosine kinases, and may play an essential role in VEGF-stimulated angiogenesis. PKC-delta has a role in EGF protection of tumor cells from TNF-alpha-induced apoptosis. PKC-delta plays a major role in antiestrogen resistance in breast tumor cells. PKC-delta selectively inhibits H2 histamine receptor-mediated activation of nonselective cation channels in differentiating granulocytic cells. PKC-mediated exclusion of LIMK2 from the nucleus might be a mechanism to relieve suppression of cyclin D1 expression by LIMK2. PKCdelta and PKCepsilon may offer novel targets for development of cancer preventive or therapeutic agents that selectively inactivate PKCepsilon or stimulate PKCdelta. PKCdelta functions in the activation of SAPK through a Lyn --> PKCdelta --> MEKK1 --> MKK7 --> SAPK signaling cascade in response to DNA damage. PKCdelta is a proproliferative factor in estrogen-dependent breast cancer cells. PKCdelta plays a positive role in protease-activated receptor-mediated dense granule secretion, whereas it functions as a negative regulator downstream of glycoprotein VI signaling. PKCdelta plays an important role in regulating 15-lipoxygenase expression in human monocytes and subsequently modulates the inflammatory responses mediated by 15-LO products. PKCdelta-dependent phosphorylation of caspase-3 is involved in the regulation of monocyte life span. PKD activation plays a central role in NT peptide secretion; upstream regulators of PKD include PKC-alpha and -delta and Rho/ROK. PLD1 is threonine-phosphorylated in human-airway epithelial cells by a PKCdelta dependent mechanism. PLS3 is a downstream effector of PKC-delta in the mitochondria. PMA activated the promoter activity of the 12(S)-lipoxygenase gene in cells PKCdelta but not PKCalpha, indicating that PKCdelta played the functional role in mediating the gene activation of 12(S)-lipoxygenase induced by PMA. PMA transactivates the EGFR and increases cell proliferation by activating the PKCdelta/c-Src pathway in glioblastoma cells. Phosphorylated PKCdelta, but not total PKCdelta, in dorsal root ganglion was decreased in diabetic rats. Decrease in phosphorylated PKCdelta is partly causes impaired neurite outgrowth in diabetes, and PKCdelta plays role in diabetic neuropathy. Phosphorylation of MUC1 by PKCdelta increases binding of MUC1 and beta-catenin in vitro and in vivo. Physical and functional interactions between protein tyrosine phosphatase alpha, PI 3-kinase, and PKCdelta. Protein kinase C delta is activated during engagement of the type II interferon receptor and participates in IFN-gamma signaling. Protein kinase C delta plays a pivotal role in stimulating monocyte NADPH oxidase activity through its regulation of phosphorylation and translocation of p47phox. Protein kinase C delta-NF-kappaB signaling regulates VCAM1 stimulation by thrombin in endothelial cells. Protein kinase C, delta negatively regulated IL-4-dependent expression of CD86. Protein kinase C-delta is a key downstream effector in the induction of interferon-beta-mediated survival of functional neutrophils at sites of inflammation. Protein kinase Cdelta has a role in lysophosphatidic acid-induced NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells. Protein kinase Cdelta regulates apoptosis via activation of STAT1. REVIEW:Interaction of protein kinase C isozymes with membranes containing anionic phospholipids utilizing fluorescent phorbol esters to probe the properties of the C1 domains. Results identify protein kinase C delta as the kinase responsible for inactivation of serum response factor both in vitro and endogenously in senescent cells. Results suggest that a protein kinase C delta-reactive oxygen species-NF-kappaB cascade plays a pivotal role in cytosolic phospholipase A(2)alpha induction by phorbol 12-myristate 13-acetate. Role of nuclear PKC delta in mediating caspase-3-upregulation in Jurkat T leukemic cells exposed to ionizing radiation. Switch chimeras, containing the C1B from epsilonPKC in the context of deltaPKC (delta(epsilonC1B)) and vice versa (epsilon(deltaC1B)), were generated and tested for their translocation in response to ceramide and arachidonic acid. The cleavage and activation of PKC-delta are critical components of UV-induced apoptosis in human keratinocytes, and the inactivation of PKC-delta can promote the survival of keratinocytes exposed to UV radiation. The delta isoform of protein kinase C (PKC) functions downstream of Ca 2+ in the signaling pathway from FcepsilonRI to degranulation in RBL-2H3 mast cells. The novel varepsilon and eta and atypical zeta, but not the conventional alpha and beta and the novel delta PKCs, may be involved in the signaling pathways involved in thrombin-induced human platelet P-selectin expression. These findings indicate that signaling via PKCdelta-p38 kinase-linked cascade specifically induces expression of VCAM-1 in lung epithelium in response to TNF-alpha and that this effect is both functionally and clinically significant. This protein is responsible for constitutive and DNA damage-induced phosphorylation of rad9 protein. Thus, a deregulation in PKCdelta was associated with reduced cellular sensitivity to cisplatin. Activation by type I interferons and mediation of Stat1 phosphorylation on serine 727. Activation of mGluR5 causes translocation of both gammaPKC and deltaPKC to the plasma membrane. deltaPKC, but not gammaPKC, phosphorylates mGluR5 Thr(840), leading to the blockade of both Ca2+ oscillations and gammaPKC cycling. Affects on JunB expression and monocyte differentiation. As a protein induced upon PKCdelta activation, PLSCR1 is required for ATRA- and PMA-triggered leukemic cell differentiation. Contributes to apoptosis by regulating p73beta protein. Data suggest that nuclear translocation and kinase activity of protein kinase C-delta are both necessary for saturated fatty acid-induced apoptosis. Despite being an apoptotic effector activated late in the apoptotic cascade, PKCdelta also activates upstream components of the death effector pathway to insure the demise of cells committed to apoptosis. Extracellular signal-regulated kinase-mediated adhesion of beta(2)-integrin caused by IL-5 is mediated in human eosinophils by a class IA PI3K through activation of a PKCdelta pathway. Heightened ERK and PKCdelta activity in high ambient glucose conditions interact with the Smad pathway, leading to enhanced responsiveness to TGF-beta1 and increased extracellular matrix production in mesangial cells. Inhibits p300 intrinsic histone acetyltransferase activity after phosphorylation at serine 89. Intracellular Cl(-) (Cl) regulates the activity of protein kinase C (PKC)-delta and thus the activation of Na-K-Cl cotransport. Overexpression of PKC delta induced cIAP-2 promoter activity and increased NF-kappa B transactivation, suggesting regulation of cIAP-2 expression by a PKC delta/NF-kappa B pathway. P38delta mitogen-activated protein kinase as a downstream carrier of the PKCdelta-dependent death signal in keratinocytes. P53 is an essential effector of PKCdelta in human colon cancer cells. Propose a previously unrecognized function of plectin as cytoskeletal regulator of PKC signaling (dislocation of PKCdelta and elevated enzymatic activity), and possibly other signaling events, through sequestration of the scaffolding protein RACK1. Protein kinase c delta regulates apoptosis [review]. Results indicate that PKCdelta inhibits TPA-induced PLD1 activation mediated by PKCalpha through the association with PLD1. Results indicate that PKCdelta plays a crucial role in activating anticancer drug-induced apoptosis signaling by amplifying the ceramide-mediated mitochondrial amplification loop. Results indicate that activation of PKC is responsible for GnRH-induced phosphorylation of both ERK1/2 and Pyk2, and that Pyk2 activation does not contribute to GnRH signaling. Results showed that PKC beta(II) and delta isozymes are essential for the activation of IL-10 production in human monocytes following stimulation by HIV-1 Tat protein. Role for the PKC-delta isoenzyme in regulating HLA class II-mediated apoptosis of mature dendritic cells. Role in regulation of eosinophil NADPH oxidase activity. Selective modulation of PKC delta may regulate TNF-R1 signaling in intestinal epithelium. Stimulus-specific modes for PKC delta signaling identified in this study allow for distinct PKC delta-mediated phosphorylation events and responses during growth factor stimulation and oxidant stress in cardiomyocytes. That the PKC delta pathway plays an important role int the control of human keratinocyte migration. The C2 domain of PKCdelta directly binds to phosphotyrosine peptides in a sequence-specific manner. The genomic structure of PRKCD was analyzed; exon-intron genomic structure is highly conserved among mammals, while significantly diverged in C. elegans. The proteolytic fragment of PKCdelta does not play a critical role in the induction of apoptosis in human small cell lung cancer cells. The signaling network involving Smad-dependent TGFbeta, PKCdelta, and integrin alpha2beta1/alpha3beta1, regulates cell spreading, motility, and invasion of the SNU16mAd gastric carcinoma cell variant. The targeting mechanism of PKCdelta, dual regulation of both its activation and translocation to the Golgi complex, is critical for ceramide-induced apoptosis. Tyrosine phosphorylation and activity of PKCdelta were dependent on PI-3K activity in B-CLL cells, and survival signals might be mediated via PKCdelta.
Hugo ID	9399


Microarray ID	A_14_P138877
	R653
	OR0817
	M15
	302
	OH2819
	1387114_at
	m18330_at
	m18330_g_at
	A_42_P786924
	104530_s_at
	104531_at
	1422847_a_at
	160698_s_at
	msa.1590.0_s_at
	x60304_at
	A_51_P460734
	A_52_P197498
	D10495 >1
	D10495 >2
	L18964
	32046_at
	202545_at
	1810_s_at
	D10495_at
	A_23_P144054
	A_14_P136903
	A_14_P104518


GenBank ID	51768363
	AJ230627
	AAA73056
	AAF64316
	AAF79208
	AAH51416
	AAS57795
	AB011812
	AF251036
	AF274044
	AI606114
	AK144231
	AK161540
	AK168768
	AK171476
	AY545076
	BAA36408
	BAE25785
	BAE36451
	BAE40604
	BC051416
	CAA42845
	M69042
	NC_000080
	NM_011103
	NP_035233
	NT_039606
	P28867
	X60304
	AAA03175
	AAA03176
	AAH43350
	AK130150
	AW293041
	BAA01381
	BC043350
	BE048101
	CAA80249
	CD369320
	D10495
	L07860
	L07861
	NC_000003
	NM_006254
	NM_212539
	NP_006245
	NP_997704
	NT_022517
	NT_086638
	Q05655
	Z22521
	AJ230628
	AJ230629
	AJ230630
	AJ230631
	AJ230632
	AJ230633
	BC076505
	CAB75578
	M18330
	NC_005115
	NM_133307
	NP_579841
	NW_047469
	P09215
	AAA41871
	AAF32345
	AAH76505
	AF219629
	AJ230615
	AJ230616
	AJ230617
	AJ230618
	AJ230619
	AJ230620
	AJ230621
	AJ230622
	AJ230623
	AJ230624
	AJ230625
	AJ230626
	6755081
	6755082
	8778119
	8778120
	51464027
	34877248
	18959249
	18959250
	7019598
	7007347
	7019311
	7019312
	7007348
	7007349
	7007350
	7007351
	7007352
	7007353
	7007354
	7007355
	7007356
	7007357
	4115529
	4115530
	7582410
	7582411
	4615281
	45330875
	45330876
	30411017
	30411018
	200380
	200381
	53436
	53437
	20141533
	7007358
	7007359
	7007360
	7007361
	7007362
	7007363
	6942179
	6942180
	49904280
	49904281
	206180
	206181
	125554
	NT_039598
	47157323
	31377782
	47157324
	47157325
	51464122
	34526895
	6699677
	27694099
	27694100
	8365237
	31153410
	520586
	520587
	189679
	189680
	189984
	189985
	509049
	509050
	547803


Chromosome position	14 11.0 cM
	3p21.31
	16p16


GO ID	0004672
	0016064
	0016301
	0042100
	0000166
	0004674
	0004701
	0005515
	0005524
	0005737
	0006468
	0007242
	0016020
	0016740
	0019992
	0046872
	0004697
	0004713
	0006917


Alias	D14Ertd420e
	NPKC-delta
	PKC(d)
	protein kinase C, delta
	AI385711
	PRKCD
	PKC delta
	PKC[d]
	Pkcd
	sphingosine-dependent protein kinase-1
	sphingosine-dependent protein kinase-1 (SDK1)
	MGC49908
	protein kinase C(d)
	DNA segment, Chr 14, ERATO Doi 420, expressed


Organism	Rattus norvegicus
	Homo sapiens
	Mus musculus


MedLine Reference	11976687
	10948194
	8357834
	11562372
	12426377


LocusLink ID	18753
	105488
	170538
	5580
	52581


FunctionalClass	kinase
	protein kinase
	ATP binding
	diacylglycerol binding
	diacylglycerol-activated phospholipid-dependent protein kinase C
	metal ion binding
	nucleotide binding
	protein binding
	protein serine/threonine kinase
	transferase
	protein kinase C
	protein-tyrosine kinase


RGD ID	67383


Hugo Symbol	PRKCD


Unigene ID	Mm.2314
	Hs.155342
	Rn.98279


GO Cellular Component	cytoplasm
	membrane


Cell Localization	Cytoplasm


Pathway	NOTCH1 -> MYOD1 signalling pathway
	NOTCH1 -> FOS signalling pathway
	NOTCH1 -> MEF2C signalling pathway
	ADRA1B -> SRF signalling pathway
	IL6ST -> MYOG signalling pathway
	LEPR -> CEBPB signalling pathway
	CD28 -> MYC signalling pathway
	CD38 -> TCF3 signalling pathway
	EPHA4 -> JUN signalling pathway
	EPHA4 -> STAT3 signalling pathway
	CHRNA7 -> CREB1 signalling pathway
	EDNRB -> SRF signalling pathway
	AGT-LRP2
	CSF1-CSF1R
	CSF1-IL6R
	CSF1-TNFRSF5
	EGF-ERBB2
	EGF-ERBB3
	EGF-ERBB4
	EGF-LRP8
	EGF-NGFR
	F2-ITGAV
	F2-LRP1
	F2-LRP2
	F2-THBD
	FGF2-CD44
	FGF2-FGFR1
	FGF2-FGFR2
	FGF2-FGFR3
	FGF2-GPC1
	FGF2-TGFBR3
	GH1-IGF1R
	HGF-CD44
	HGF-FGFR2
	HGF-IL6R
	HGF-MET
	IFNA1-CR2
	IFNA1-IFNAR1
	IFNA1-IFNAR2
	IFNB1-IFNAR1
	IFNB1-IFNAR2
	IFNG-HLA-C
	IFNG-IFNGR1
	IFNG-IFNGR2
	IGF1-BST1
	IGF1-IGF2R
	IGF1-LRP5
	IGF2-IGF1R
	IL13-IL13RA1
	IL13-IL13RA2
	IL1A-IL1RAP
	IL1B-HLA-DRB1
	IL1B-IL1R1
	IL1B-IL1RAP
	IL1B-IL6R
	IL4-FCER2
	IL5-IL6ST
	IL6-IL6R
	IL6-IL6ST
	IL6-LIFR
	IL6-TNFRSF5
	INS-EGFR
	INS-HLA-DRB1
	INS-TFRC
	LIF-IGF2R
	LIF-IL6ST
	LIF-LIFR
	NGFB-NGFR
	NGFB-NTRK1
	NGFB-NTRK2
	NGFB-NTRK3
	NPPA-NPTXR
	OSM-CD22
	PTH-IL6ST
	SDF1-IL6ST
	TGFB1-ACVR1
	TGFB1-ACVR1B
	TGFB1-ACVR2
	TGFB1-ACVR2B
	TGFB1-ACVRL1
	TGFB1-BMPR1B
	TGFB1-CD44
	TGFB1-IGF2R
	TGFB1-IL6R
	TGFB1-M6PR
	TGFB1-SELE
	TGFB1-SELL
	TGFB1-TGFBR1
	TGFB1-TGFBR2
	TGFB1-TGFBR3
	TNF-IL15RA
	TNF-NGFR
	TNF-TNFRSF1B
	VEGF-CD44
	VEGF-EGFR
	VEGF-FLT1
	VEGF-FLT4
	VEGF-GPC1
	VEGF-IL1R1
	VEGF-KDR
	mTOR
	simple mTOR


GO Biological Process	induction of apoptosis
	intracellular signaling cascade
	protein amino acid phosphorylation
	B cell proliferation
	humoral defense mechanism (sensu Vertebrata)
	B-cell proliferation


Group	Kinases


EC Number	2.7.1.-
	2.7.1.37


State Description	Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
	Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to variant 1. Both variants encode the same protein.


MGI ID	97598


Swiss-Prot Accession	Q05655


OMIM ID	176977


Source	Curated