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VEGF Interactive Pathway: Rac1
 
Inhibitors
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Rac1 Inhibitor 553502
InSolution™ Rac1 Inhibitor 553508
 
Proteins/Enzymes
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Rac1, GST-Fusion, Human, Recombinant, E. coli 552134
Rac1, His•Tag®, Human, Recombinant, E. coli 552137
 
Additional Information
 
 
 
 

Protein : Rac1

Name Rac1
Description ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Owner Public
URN urn:agi-llid:5879
Connectivity 181
Notes The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two splice variants have been found which differ in the presence or absence of exon 3b.
Hugo ID 9801
Microarray ID D25274_at
A_32_P758832
H3018C09-3
A_51_P513254
208640_at
40864_at
208641_s_at
1567457_at
1567458_s_at
2050_s_at
A_32_P217709
A_14_P129563
A_14_P115188
A_14_P105823
A_23_P215406
A_23_P388071
A_24_P194845
M523
C309
OH8100
CA429
OH7287
I_1943918
NM_006908.2
I_930828
A_23_P22639
I_1000719
1388332_at
rc_AA799542_at
AA848238_at
101555_at
1423734_at
1437674_at
1451086_s_at
134979_f_at
168293_i_at
x57277_s_at
Msa.2630.0_at
AK034601
A_65_P18486
H3159G02-3
A_65_P16230
GenBank ID XM_357522
XP_357522
AU022720
P15154
NT_039317
XM_132485
XP_132485
51711465
45592933
45592934
12842615
12842616
12843554
12843555
15919904
15919905
26330056
26330057
26339063
26339064
26344957
26344958
26349264
26349265
26353931
26353932
6645599
13277917
13277918
29835221
29835222
53885
53886
XM_344079
XP_344080
34870462
34870448
34870449
14532300
14532301
40354187
40354188
51701705
54607147
54607146
AAK66567
AAR84574
AF385833
AY491395
NC_005111
NM_134366
NP_599193
NW_047368
Q6RUV5
AAA36537
AAA36544
AAB22206
AAD30547
AAH04247
AAH50687
AAM21111
AAP35785
AAQ16632
AAS07511
AAS07512
AC009412
AF136373
AF498964
AJ132694
AJ132695
AK054993
AK122742
AL833528
AY279384
BC004247
BC050687
BG437715
BQ689587
BT007121
CAA10732
CAA10733
CAB53579
CH236963
CR591797
CR624866
D25274
EAL23718
EAL23719
EAL23720
M29870
M31467
NC_000007
NM_006908
NM_018890
NM_198829
NP_008839
NP_061485
NP_942126
NT_007819
NT_079592
NT_086702
P63000
AAH51053
AK008435
AK009017
AK011072
AK034601
AK047969
AK076023
AK081613
AK088825
AK166383
AK184868
AK186906
AK190884
AK193118
AK195884
AK199407
AK216533
AL023026
BAB25667
BAB26027
BAB69451
BAC28767
BAC33203
BAC36128
BAC38272
BAC40596
BAE38744
BC003828
BC051053
CAA40545
NC_000071
NM_009007
NP_033033
NT_081055
P63001
X57277
AAH03828
51702788
20848374
9845511
51475902
38505163
38505162
9845509
38505164
38505165
37538986
51466684
14190769
41473432
41473433
8574037
8574039
8574038
21734172
51094453
51094459
51094460
51094461
4836768
4836769
20379101
20379102
4454210
4454211
16549633
34527937
33358320
33358321
13279010
13279011
29792301
29792302
13344221
21814903
30583080
30583081
50472604
50505673
464185
190823
190824
190874
190875
51702787
249582
68958
13096548
AK082996
26100996
NT_039324
Chromosome position 7p22
12p11
5 82.0 cM
GO ID 0015031
GO:0003925
GO:0003931
GO:0003924
GO:0005525
GO:0005515
GO:0007264
GO:0009611
GO:0007155
GO:0007242
GO:0006928
GO:0006954
GO:0016358
GO:0030032
GO:0030838
GO:0016023
GO:0005737
GO:0019897
GO:0009653
GO:0007345
0006935
0008283
0016601
0000166
0005525
0007264
0005624
0005737
0006897
0006928
0006954
0006972
0007010
0007155
0007242
0009611
0016023
0016358
0016477
0019897
0030027
0030032
0030838
0003924
0005515
Alias DNA segment, Chr 5, ERATO Doi 559, expressed
C530030B14Rik
RIKEN cDNA C530030B14 gene
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
HAP-2
rho family, small GTP binding Rac
AL023026
expressed sequence AL023026
ras-related C3 botulinum toxin substrate I
ras-related C3 botulinum toxin substrate 1
GTP-binding protein rac I
Rac I
ras-related C3 botulinum toxin substrate 1 isoform Rac I
Rac1
D5Ertd559e
RAS-related C3 botulinum substrate 1
Rac(V12)
RAS-related C3 botulinum substrate I
RAC1_HUMAN
rho family, small GTP binding protein Rac I
p21-Rac I
Ras-like protein TC25
TC-25
GTP-binding protein rac1
isoform rac1b
rac1c
migration-inducing protein 5
migration-inducing protein V
p21-Rac1
ras-related C3 botulinum toxin substrate 1 isoform Rac1
ras-related C3 botulinum toxin substrate 1 isoform Rac1b
rho family, small GTP binding protein Rac1
Organism Mus musculus
Homo sapiens
Rattus norvegicus
Human
MedLine Reference 11756405
12105187
12672819
10699171
12213441
12351724
12446704
12466851
12525493
12783890
12853475
14516655
14573547
14580336
14657280
15249579
15728191
LocusLink ID 319353
52352
100781
363875
171377
19353
5879
FunctionalClass GTP binding
nucleotide binding
GTPase
protein binding
RGD ID 619755
Hugo Symbol RAC1
Unigene ID Rn.29157
Mm.292510
Hs.413812
Mm.355686
Rn.980
Mm.889
Hs.173737
Keyword small monomeric GTPase
gtpase
guanine nucleotide exchange factor
guanine nucleotide dissociation factor
PKC
GDI
GTPase activity
Rho small monomeric GTPase
GO Cellular Component cytoplasm
cytoplasmic membrane-bound vesicle
extrinsic to plasma membrane
lamellipodium
membrane fraction
cytoplasmic vesicle
GO Molecular Function small monomeric GTPase activity
Rho small monomeric GTPase activity
GTPase activity
GTP binding
protein binding
GTP binding activity
Cell Localization Plasma membrane
Cytoplasm
Pathway CREB signaling
p38 Signaling
EPHA3
EPHA2
IL1R1 -> RUNX2 signalling pathway
IL1R1 -> STAT3 signalling pathway
ICAP-1A -> MYC signalling pathway
AGT-LRP2
CCL19-CD44
CD86-CD28
CSF1-CSF1R
CSF1-IL6R
CSF1-TNFRSF5
CSF3-IL6R
DTR-CD44
EFNB1-EPHB2
EFNB1-FGFR2
EGF-EGFR
EGF-ERBB2
EGF-ERBB3
EGF-ERBB4
EGF-LRP8
EGF-NGFR
F2-ITGAV
F2-LRP1
F2-LRP2
F2-THBD
FGF2-CD44
FGF2-FGFR1
FGF2-FGFR2
FGF2-FGFR3
FGF2-GPC1
FGF2-TGFBR3
FGF4-CD44
FGF8-CD44
HGF-CD44
HGF-FGFR2
HGF-IL6R
HGF-MET
IFNA1-CR2
IFNA1-IFNAR1
IFNA1-IFNAR2
IFNG-HLA-C
IFNG-IFNGR1
IFNG-IFNGR2
IL1A-IL1RAP
IL1B-IL1RAP
IL2-IL15RA
IL2-IL2RA
IL2-IL2RB
IL2-IL4R
IL3-CD8A
IL3-CSF2RB2
IL3-EPOR
IL3-IL3RA
IL6-IL6R
IL6-IL6ST
IL6-LIFR
IL6-TNFRSF5
INS-EGFR
INS-HLA-DRB1
INS-IGF1R
INS-TFRC
KITLG-KIT
NGFB-NGFR
NGFB-NTRK1
NGFB-NTRK2
NGFB-NTRK3
NPPA-NPTXR
NRG1-CD44
NTN1-HLA-C
NTN1-UNC5H2
PDGFB-PDGFRB
SDF1-CD4
SDF1-IL6ST
SPP1-CD44
TAC1-TNFRSF11B
TGFB1-ACVR1
TGFB1-ACVR1B
TGFB1-ACVR2
TGFB1-ACVR2B
TGFB1-ACVRL1
TGFB1-BMPR1B
TGFB1-CD44
TGFB1-IGF2R
TGFB1-IL6R
TGFB1-M6PR
TGFB1-SELE
TGFB1-SELL
TGFB1-TGFBR1
TGFB1-TGFBR2
TGFB1-TGFBR3
TNF-IL15RA
TNF-NGFR
TNF-TNFRSF1A
TNF-TNFRSF1B
TNF-TNFRSF6
TNFSF6-TNFRSF6
VEGF-CD44
VEGF-EGFR
VEGF-FLT1
VEGF-FLT4
VEGF-GPC1
VEGF-IL1R1
VEGF-KDR
CB0479 MAPK
GO Biological Process cell adhesion
cell migration
cell motility
cytoskeleton organization and biogenesis
dendrite morphogenesis
endocytosis
hyperosmotic response
inflammatory response
intracellular signaling cascade
lamellipodium biogenesis
positive regulation of actin filament polymerization
response to wounding
Rac protein signal transduction
cell proliferation
chemotaxis
small GTPase mediated signal transduction
protein transport
morphogenesis
lamellipodium formation
positive regulation of actin polymerization
embryogenesis and morphogenesis
Group Gtp binding proteins
State ras-related C3 botulinum toxin substrate 1 isoform Rac1
ras-related C3 botulinum toxin substrate 1 isoform Rac1b
ras-related C3 botulinum toxin substrate 1 isoform Rac1c
State Description Transcript Variant: This variant (Rac1c) differs in the 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant Rac1. These differences cause translation initiation at a downstream ATG resulting in isoform Rac1c which is short...
Transcript Variant: This variant (Rac1) has a 57 bp in-frame deletion of exon 3b in the coding region, as compared to the variant Rac1b.
Transcript Variant: This variant (Rac1b) includes the alternatively spliced 57 bp region (exon 3b) that is missing in transcript variant Rac1.
MGI ID 97845
2441909
Swiss-Prot Accession P15154
OMIM ID 602048
OMIM:602048
Source Curated
BIND
ResNet
 
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