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VEGF Interactive Pathway: SHC
 
SHC Antibodies
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 Cat. No.
PhosphoDetect™ Anti-Shc (pTyr239/240) Mouse mAb (1E3) ELISA, IB human, mouse 566808
Anti-Shc Rabbit pAb ELISA, IC, IH, IP human, mouse, rat ST1033
PhosphoDetect™ Anti-Shc/p66 (pSer36) Mouse mAb (6E10) ELISA, IB human, mouse 566807
 
Additional Information
 
 
 
 

Protein : SHC1

Name SHC1
Description SHC (Src homology 2 domain containing) transforming protein 1
Owner Public
URN urn:agi-llid:6464
Connectivity 299
Notes Adaptor protein; couples activated growth factor receptors to a signaling pathway; contains an SH2 domain
Hugo ID 10840
Microarray ID msa.1387.0_s_at
A_51_P228732
A_65_P17586
A_52_P384250
A_23_P200443
A_14_P109651
A_14_P136319
A_14_P109823
A_24_P68585
214853_s_at
201469_s_at
38118_at
U73377_at
31445_at
rc_n94601_s_at
rc_w81235_f_at
M438
OH7367
1422853_at
93713_at
1422854_at
GenBank ID AAH36172
AF455140
AI050321
AK036980
AK049357
AK155158
AK191292
AK195313
AK199216
AK203451
AK205229
AK211173
BAC33706
BAE33083
BC036172
NC_000069
NM_011368
NP_035498
NT_039234
P98083
U15784
U46956
51458934
34147725
32261324
51460383
21541499
21541500
21541501
19309454
55960108
55960109
55960110
55960111
55960112
55960113
55960114
55960115
55960116
1834514
1834515
21755590
15080062
33988796
15559595
16878154
21706899
21706900
34366164
34366177
1658387
1899055
36453
36454
17380299
52693921
52693920
10835031
33859843
284403
21218438
XP_216176
NW_043538
XM_215618
XP_215618
NW_043758
XM_216176
NT_004668
UNC: Adaptor protein; couples activated growth factor receptors to a signaling pathway; contains an SH2 domain
BAC28066
XP_342283
34858271
34857982
34857983
4249547
4249548
H3081F12-3
C330027D01
51708226
31543699
15778828
21541496
14211983
14211984
3299438
26340085
26340086
23273600
23273601
558998
558999
21264509
AAB49972
AAH14158
AAH33925
AAM61859
AAM61860
AB208849
AF455141
AK096169
AK130014
AL451085
BAD92086
BC011813
BC014158
BC017283
BC033925
BX647136
BX647149
CAA48251
CAA70977
CAI13246
CAI13247
CAI13248
CAI13249
CAI13250
CAI13251
CAI13252
CAI13253
CAI13254
NC_000001
NM_003029
NM_183001
NP_003020
NP_892113
NT_004487
NT_086596
AAH88298
BAA74950
BC088298
D83015
NC_005101
NM_053517
NP_445969
NW_047626
XM_342282
P29353
U73377
X68148
Y09847
AAA91777
AAC52146
Chromosome position 1q21
3 45.0 cM
2q34
GO ID GO:0005515
GO:0008151
GO:0007242
GO:0001558
GO:0005068
GO:0007176
GO:0007173
GO:0008284
GO:0007048
0000187
0001558
0005068
0005543
0005886
0007176
0007242
0008284
0045840
0005515
Alias Sck (Rattus rattus)
SHC (Src homology 2 domain-containing) transforming protein I
similar to p52(Shc) - mouse
p66
p52
Shc-1
p55
SHC (Src homology 2 domain containing) transforming protein 1
P-66
P 66
similar to p52(Shc) protein - mouse
similar to Sck [Rattus rattus]
similar to Sck (Rattus rattus)
similar to p52(Shc) protein
hypothetical protein 6720466E06
SHC (Src homology 2 domain-containing) transforming protein 1
SHC transforming protein
Shc1
(Src homology 2 domain-containing) transforming 1
(Src homology 2 domain-containing) transforming I
SHCA
src homology 2 domain-containing transforming protein C1
Shc I
p66Shc
Shc-P
6720466E06
src homology 2 domain-containing transforming protein C
p52Shc
flj26504
SHC
P(66)
Organism Homo sapiens
Rattus norvegicus
Mus musculus
Human
MedLine Reference 14676841
1623525
11877420
12808090
LocusLink ID 20416
85385
6464
295250
216148
FunctionalClass phospholipid binding
transmembrane receptor protein tyrosine kinase adaptor protein
protein binding
RGD ID 620446
Hugo Symbol SHC1
Unigene ID Rn.119060
Mm.86595
Hs.433795
Rn.6818
Rn.52162
Hs.81972
Mm.259499
Keyword docking protein
sh-2 domain
tumor antigen
collagen
GO Cellular Component plasma membrane
GO Molecular Function protein binding
transmembrane receptor protein tyrosine kinase adaptor protein activity
protein binding activity
Cell Localization Cytoplasm
Plasma membrane
Pathway PDGF signaling
Insulin pathway
IL-6 signaling
IL-3 signaling
IL-2 signaling
IL-1 and IL-6 signaling
Erythropoietin signaling
Erk-PI3K in Collagen Binding
EGF signaling
Antiapoptotic Pathways From IGF-1R
MAPK-ERK in Growth and Differentiation
SAPK-JNK Signaling
PTEN signaling
Insulin Receptor Signaling
Integrin Signaling
G-protein Coupled Receptor signaling
NGF signaling
p38 Signaling
Vasopressin
Substance P
PDGFRB
Oxytocin
opioids OPRD1
Nociceptin
Neurotensin
HGF
Gastrin
EPHB1
Endothelin
EGF
Cholecystokinin
Bombesin
MST1R -> CTNNB1 signalling pathway
ACVR1B -> MADH1 signalling pathway
NGFR -> JUN signalling pathway
NGFR -> CEBPB signalling pathway
NGFR -> CREB1 signalling pathway
NOTCH1 -> MYT1 signalling pathway
NOTCH1 -> NFKB2 signalling pathway
NOTCH1 -> LEF1 signalling pathway
NOTCH1 -> HEY1 signalling pathway
NOTCH1 -> HEY2 signalling pathway
NOTCH1 -> E2F1 signalling pathway
NOTCH4 -> HEY1 signalling pathway
NTRK1 -> MYC signalling pathway
NTRK1 -> RUNX1 signalling pathway
NTRK1 -> FOXO1A signalling pathway
NTRK1 -> FOS signalling pathway
NTRK1 -> STAT5A signalling pathway
NTRK1 -> CTNNB1 signalling pathway
NTRK1 -> MADH3 signalling pathway
NTRK3 -> STAT5A signalling pathway
OPRM1 -> FOS signalling pathway
OPRM1 -> STAT3 signalling pathway
TEK -> STAT3 signalling pathway
TEK -> STAT5A signalling pathway
TRIO -> MYC signalling pathway
ADORA1 -> FOS signalling pathway
ADRA1B -> SRF signalling pathway
ADRA1B -> STAT3 signalling pathway
ADRB1 -> MYC signalling pathway
ADRB1 -> STAT3 signalling pathway
ADRB2 -> POU2AF1 signalling pathway
AGTR1 -> STAT1 signalling pathway
AGTR2 -> IRF1 signalling pathway
ALK -> STAT3 signalling pathway
HTR2A -> FOS signalling pathway
VIPR1 -> CREB1 signalling pathway
IFNAR1 -> IRF7 signalling pathway
IFNAR1 -> CDX2 signalling pathway
IGF1R -> MYC signalling pathway
IGF1R -> RUNX2 signalling pathway
IGF1R -> FOXO1A signalling pathway
IGF1R -> FOS signalling pathway
IGF1R -> SREBF1 signalling pathway
IGF1R -> STAT1 signalling pathway
IGF1R -> CEBPA signalling pathway
IGF1R -> CTNNA1 signalling pathway
IGF1R -> EGR1 signalling pathway
IGF2R -> ELF4 signalling pathway
IL2RB -> FOS signalling pathway
IL3RA -> STAT3 signalling pathway
IL3RA -> STAT5A signalling pathway
IL3RA -> STAT5B signalling pathway
IL4R -> MYC signalling pathway
IL4R -> HMGY signalling pathway
IL4R -> STAT5A signalling pathway
IL6R -> CEBPA signalling pathway
IL6ST -> MYC signalling pathway
IL6ST -> STAT5B signalling pathway
IL7R -> LEF1 signalling pathway
IL7R -> TCF3 signalling pathway
IL7R -> PAX5 signalling pathway
KLRG1 -> IPF1 signalling pathway
KLRG1 -> PAX6 signalling pathway
ITGA2B -> BCL3 signalling pathway
ITGAM -> JUN signalling pathway
ITGAM -> RELA signalling pathway
ITGB1 -> VAV1 signalling pathway
ITGB1 -> SREBF1 signalling pathway
ITGB1 -> CTNNA1 signalling pathway
ITGB3 -> VAV1 signalling pathway
CEACAM1 -> VAV1 signalling pathway
BMPR2 -> MADH5 signalling pathway
KDR -> HIF1A signalling pathway
KDR -> HSPCA signalling pathway
KDR -> ATF1 signalling pathway
KDR -> ETS1 signalling pathway
KDR -> STAT1 signalling pathway
KDR -> STAT6 signalling pathway
KDR -> TAL1 signalling pathway
KDR -> CTNNB1 signalling pathway
KDR -> EGR3 signalling pathway
DDR1 -> TP53 signalling pathway
KIT -> FOS signalling pathway
KIT -> STAT1 signalling pathway
KIT -> STAT3 signalling pathway
KIT -> PAX5 signalling pathway
CCKAR -> FOS signalling pathway
CCKBR -> FOS signalling pathway
CCKBR -> STAT3 signalling pathway
CCKBR -> EGR1 signalling pathway
LDLR -> SREBF1 signalling pathway
CD2 -> GATA3 signalling pathway
CD2 -> STAT4 signalling pathway
CD3Z -> VAV1 signalling pathway
CD4 -> VAV1 signalling pathway
CD4 -> STAT5B signalling pathway
CD14 -> ICSBP1 signalling pathway
CD19 -> JUND signalling pathway
CD19 -> FOS signalling pathway
CD22 -> VAV1 signalling pathway
CD28 -> HMGY signalling pathway
CD28 -> VAV1 signalling pathway
CD28 -> BCL6 signalling pathway
CD28 -> FOS signalling pathway
CD28 -> STAT6 signalling pathway
CD28 -> TCF3 signalling pathway
CD28 -> CREB1 signalling pathway
CD28 -> REL signalling pathway
CD28 -> EGR2 signalling pathway
CD38 -> MYBL1 signalling pathway
TNFRSF5 -> MYC signalling pathway
CD79A -> PAX5 signalling pathway
KLRA1 -> TCF1 signalling pathway
KLRA1 -> CTNNB1 signalling pathway
EPHA1 -> JUN signalling pathway
EPHA3 -> STAT3 signalling pathway
EPHA3 -> TCF3 signalling pathway
EPHA3 -> ELF1 signalling pathway
EPOR -> MYC signalling pathway
EPOR -> SPI1 signalling pathway
EPOR -> STAT3 signalling pathway
ERBB2 -> TP53 signalling pathway
ERBB2 -> STAT3 signalling pathway
ERBB2 -> STAT5B signalling pathway
ERBB2 -> ELF3 signalling pathway
ERBB3 -> MYOG signalling pathway
ERBB3 -> NFKB1 signalling pathway
ERBB4 -> ATF4 signalling pathway
ERBB4 -> STAT5A signalling pathway
ERBB4 -> STAT5B signalling pathway
FCGR2B -> YY1 signalling pathway
FCGR2B -> GATA4 signalling pathway
FCGR3A -> MYC signalling pathway
FCGR3A -> FOS signalling pathway
FCGR3A -> STAT5A signalling pathway
FGFR1 -> STAT1 signalling pathway
FGFR3 -> SOX9 signalling pathway
FGFR3 -> STAT1 signalling pathway
FGFR3 -> STAT3 signalling pathway
FGFR3 -> STAT5A signalling pathway
FGFR3 -> STAT5B signalling pathway
FLT3 -> HSPCA signalling pathway
FLT3 -> FOXO3A signalling pathway
FLT3 -> SPI1 signalling pathway
FLT3 -> STAT5A signalling pathway
FLT3 -> CEBPA signalling pathway
SPN -> VAV1 signalling pathway
SPN -> TCF3 signalling pathway
GCGR -> TP53 signalling pathway
GHR -> FOS signalling pathway
GHR -> EGR1 signalling pathway
GNRHR -> FOS signalling pathway
GNRHR -> EGR1 signalling pathway
GRIA2 -> FOS signalling pathway
GRIA3 -> FOS signalling pathway
PDGFRB -> MYC signalling pathway
PDGFRB -> FOS signalling pathway
PDGFRB -> STAT1 signalling pathway
PDGFRB -> STAT3 signalling pathway
PECAM1 -> SP1 signalling pathway
EDG5 -> FOS signalling pathway
CCR5 -> TP53 signalling pathway
CCR5 -> STAT1 signalling pathway
CCR5 -> STAT3 signalling pathway
CCR5 -> CTNNA1 signalling pathway
CNR1 -> EGR1 signalling pathway
CNR2 -> EGR1 signalling pathway
CSF1R -> MYC signalling pathway
CSF1R -> STAT3 signalling pathway
PRLR -> VAV1 signalling pathway
PRLR -> IRF1 signalling pathway
PTGDR -> CTNNB1 signalling pathway
PTGDR -> EGR1 signalling pathway
PTPRE -> MYC signalling pathway
PTPRE -> IRF1 signalling pathway
DRD3 -> FOS signalling pathway
RET -> HSF1 signalling pathway
RET -> JUND signalling pathway
EGFR -> VAV1 signalling pathway
EGFR -> BRCA1 signalling pathway
EGFR -> CTNNB1 signalling pathway
M6PR -> ELF4 signalling pathway
MET -> TP53 signalling pathway
MET -> ETS1 signalling pathway
MET -> FOS signalling pathway
MET -> STAT3 signalling pathway
MET -> STAT5A signalling pathway
MET -> TAL1 signalling pathway
MET -> EGR1 signalling pathway
MET -> MADH2 signalling pathway
MET -> MAX signalling pathway
MPL -> STAT3 signalling pathway
MPL -> STAT5A signalling pathway
MPL -> CEBPA signalling pathway
AGT-LRP2
AREG-EGFR
BDNF-NCAM1
BDNF-NGFR
BDNF-NTRK1
BDNF-NTRK2
BDNF-NTRK3
BTC-EGFR
CCL19-IL2RB
CSF1-CSF1R
CSF1-IL6R
CSF1-TNFRSF5
CSF2-CSF2RA
CYR61-ITGAV
DTR-EGFR
DTR-ERBB4
EFNB2-EPHB1
EGF-EGFR
EGF-ERBB2
EGF-ERBB3
EGF-ERBB4
EGF-LRP8
EGF-NGFR
EPO-EPOR
EREG-EGFR
EREG-ERBB4
F2-ITGAV
F2-LRP1
F2-LRP2
F2-THBD
FGF1-FGFR3
FGF2-CD44
FGF2-FGFR1
FGF2-FGFR2
FGF2-FGFR3
FGF2-GPC1
FGF2-TGFBR3
FGF8-FGFR3
FGF9-FGFR3
FIGF-FLT4
FIGF-KDR
GDNF-RET
GH1-GHR
GH1-IGF1R
GH1-PRLR
GRO1-EGFR
HGF-CD44
HGF-FGFR2
HGF-IL6R
HGF-MET
IGF1-BST1
IGF1-IGF2R
IGF1-LRP5
IGF2-IGF1R
IL15-IL15RA
IL15-IL2RB
IL15-IL2RG
IL2-IL15RA
IL2-IL2RA
IL2-IL2RB
IL2-IL2RG
IL2-IL4R
IL3-CD8A
IL3-CSF2RB2
IL3-EPOR
IL3-IL3RA
IL5-IL5RA
IL5-IL6ST
IL6-IL6R
IL6-IL6ST
IL6-LIFR
IL6-TNFRSF5
IL7-IL2RG
IL7-IL7R
INS-EGFR
INS-HLA-DRB1
INS-TFRC
KITLG-KIT
LEP-LEPR
LEP-LRP2
LIF-IGF2R
LIF-IL6ST
LIF-LIFR
MUC4-ERBB2
NGFB-NGFR
NGFB-NTRK1
NGFB-NTRK2
NGFB-NTRK3
NRG1-EGFR
NRG1-ERBB2
NRG1-ERBB3
NRG1-ERBB4
NRG2-ERBB3
NTF3-CNTFR
NTF3-NGFR
NTF3-NTRK1
NTF3-NTRK2
NTF3-NTRK3
NTF5-NGFR
NTF5-NTRK1
NTF5-NTRK2
NTF5-NTRK3
NUDT6-FGFR1
OSM-CD22
OSM-IL6ST
OSM-LIFR
PGF-KDR
PRL-PRLR
SDF1-IL6ST
TAC1-TNFRSF11B
TGFA-EGFR
TGFB1-ACVR1
TGFB1-ACVR1B
TGFB1-ACVR2
TGFB1-ACVR2B
TGFB1-ACVRL1
TGFB1-BMPR1B
TGFB1-CD44
TGFB1-IGF2R
TGFB1-IL6R
TGFB1-M6PR
TGFB1-SELE
TGFB1-SELL
TGFB1-TGFBR1
TGFB1-TGFBR2
TGFB1-TGFBR3
THBS1-ITGB1
THPO-EPOR
THPO-MPL
TNF-IL15RA
TNF-NGFR
TNF-TNFRSF1B
VEGF-CD44
VEGF-EGFR
VEGF-FLT1
VEGF-FLT4
VEGF-GPC1
VEGF-IL1R1
VEGF-KDR
VEGFC-FLT1
VEGFC-FLT4
VEGFC-KDR
CB0479 MAPK
CB0480 Insulin
GO Biological Process activation of MAPK
intracellular signaling cascade
positive regulation of cell proliferation
positive regulation of mitosis
regulation of cell growth
regulation of epidermal growth factor receptor
regulation of epidermal growth factor receptor activity
cell growth and/or maintenance
regulation of EGF receptor activity
EGF receptor signaling pathway
oncogenesis
Group Ph
Sh2
State isoform p52Shc
isoform p66Shc
MGI ID 98296
Swiss-Prot Accession P29353
OMIM ID 600560
OMIM:600560
Source Curated
BIND
ResNet
 
 
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